Enhancement of Natural Killer Cell Activity in Healthy Subjects by Immulina, a Spirulina Extract Enriched for Braun-Type Lipoproteins

• Published in: Planta medica Vol. 76; no. 16; p. 1802
• Main Authors: Nielsen, Claus Henrik, Balachandran, Premalatha, Christensen, Ole, Pugh, Nirmal D, Tamta, Hemlata, Sufka, Kenneth J, Wu, Xiangmei, Walsted, Anette, Schjørring-Thyssen, Michelle, Enevold, Christian, Pasco, David S
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2010
• Subjects: Adjuvants, Immunologic - pharmacology; Adjuvants, Immunologic - therapeutic use; Adult; Aged; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Arthrospira; Biomarkers - metabolism; CD4-positive T-lymphocytes; Cell Line, Tumor; Cross-Over Studies; diet; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; gene expression; Humans; Killer Cells, Natural - drug effects; Leukemia, Erythroblastic, Acute - drug therapy; Leukocytes, Mononuclear - drug effects; lipoproteins; Lipoproteins - pharmacology; Lipoproteins - therapeutic use; Lymphocyte Activation - drug effects; Male; messenger RNA; mice; Middle Aged; monocytes; natural killer cells; NK Cell Lectin-Like Receptor Subfamily K - genetics; NK Cell Lectin-Like Receptor Subfamily K - metabolism; Perforin - genetics; Perforin - metabolism; Phytotherapy; Pilot Projects; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Reference Values; RNA, Messenger - metabolism; Spirulina; Spirulina - chemistry; T-Lymphocytes; Young Adult

Immulina, a commercial extract of Arthrospira (Spirulina) platensis is a potent activator of THP-1 monocytes and CD4+ T cells IN VITRO and enhances several immunological functions in mice. We further characterized Immulina by determining that Braun-type lipoproteins are responsible for a major porti...