The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis

The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central R...

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Published inInternational journal of environmental research and public health Vol. 17; no. 17; p. 6056
Main Authors Azevedo, Kesley Pablo Morais de, de Oliveira, Victor Hugo, Medeiros, Gidyenne Christine Bandeira Silva de, Mata, Ádala Nayana de Sousa, García, Daniel Ángel, Martínez, Daniel Guillén, Leitão, José Carlos, Knackfuss, Maria Irany, Piuvezam, Grasiela
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.08.2020
MDPI
Subjects
Adolescent
Adolescents
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Cognition & reasoning
Confidence intervals
Exercise
Female
Humans
Literature reviews
Male
Meta-analysis
Randomization
Review
Reviews
Studies
Teenagers
meta-analysis
adolescent
exercise
brain-derived neurotrophic factor
systematic review
BDNF
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Abstract The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10-19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval -0.28 to 0.85; = 0.32, I² = 0%). The results presented in our review indicate that aerobic exercise programs practiced in moderate- or high-intensity are promising strategies to increase BDNF levels in adolescents. However, further studies are required to support this finding.
AbstractList The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10–19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval −0.28 to 0.85; p = 0.32, I² = 0%). The results presented in our review indicate that aerobic exercise programs practiced in moderate- or high-intensity are promising strategies to increase BDNF levels in adolescents. However, further studies are required to support this finding.
The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10–19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval −0.28 to 0.85; p = 0.32, I² = 0%). The results presented in our review indicate that aerobic exercise programs practiced in moderate- or high-intensity are promising strategies to increase BDNF levels in adolescents. However, further studies are required to support this finding.
The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10-19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval -0.28 to 0.85; = 0.32, I² = 0%). The results presented in our review indicate that aerobic exercise programs practiced in moderate- or high-intensity are promising strategies to increase BDNF levels in adolescents. However, further studies are required to support this finding.
Author Medeiros, Gidyenne Christine Bandeira Silva de
Azevedo, Kesley Pablo Morais de
García, Daniel Ángel
Piuvezam, Grasiela
de Oliveira, Victor Hugo
Mata, Ádala Nayana de Sousa
Martínez, Daniel Guillén
Leitão, José Carlos
Knackfuss, Maria Irany
AuthorAffiliation 5 Post-Graduate Program in Health and Society, State University of Rio Grande do Norte (UERN), 59610-210 Mossoró, Brazil; kmariairany@yahoo.com.br
2 Department of Sociosanitary Sciences, University of Murcia, 30100 Murcia, Spain; angelgarcia.da@gmail.com
3 Faculty of Nursing, Catholic University of Murcia (UCAM), 30107 Murcia, Spain; dguillen@ucam.edu
1 Post-Graduate Program in Public Health, Federal University of Rio Grande do Norte, 59078-970 Natal, Brazil; victorhugoef@hotmail.com (V.H.d.O.); gidyenne@gmail.com (G.C.B.S.d.M.); adalamata@gmail.com (Á.N.d.S.M.); gpiuvezam@yahoo.com.br (G.P.)
4 Center for Research in Sport, Health and Human Development, University of Trás-os-Montes and Alto Douro, 5001-801 Vila Real, Portugal; jcleitao@utad.pt
AuthorAffiliation_xml – name: 5 Post-Graduate Program in Health and Society, State University of Rio Grande do Norte (UERN), 59610-210 Mossoró, Brazil; kmariairany@yahoo.com.br
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– name: 3 Faculty of Nursing, Catholic University of Murcia (UCAM), 30107 Murcia, Spain; dguillen@ucam.edu
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32825341$$D View this record in MEDLINE/PubMed
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Issue 17
Keywords meta-analysis
adolescent
exercise
brain-derived neurotrophic factor
systematic review
BDNF
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SubjectTerms Adolescent
Adolescents
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Cognition & reasoning
Confidence intervals
Exercise
Female
Humans
Literature reviews
Male
Meta-analysis
Randomization
Review
Reviews
Studies
Teenagers
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Title The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis
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Volume 17
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