Neutralization and Enhancement of HIV-1 Infection by Sera from HIV-1 Infected Individuals Who Progress to Disease at Different Rates

• Published in: Virology (New York, N.Y.) Vol. 273; no. 1; pp. 52 - 59
• Main Authors: Jolly, Pauline E., Weiss, Heidi L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.07.2000
• Subjects: Acquired Immunodeficiency Syndrome - immunology; Acquired Immunodeficiency Syndrome - pathology; Cells, Cultured; Disease Progression; HIV Infections - immunology; HIV Infections - pathology; HIV-1 - drug effects; HIV-1 - immunology; HIV-1 - physiology; Human immunodeficiency virus 1; Humans; Immune Sera - immunology; Immune Sera - pharmacology; Kinetics; Macrophages - drug effects; Macrophages - virology; Neutralization Tests; Time Factors; Virus Replication - drug effects

We examined the neutralizing/enhancing activity in sera collected at an early and a later time point postinfection from 13 HIV-positive nonprogressors, 13 moderate progressors, and 13 rapid progressors to determine the relationship between neutralizing/enhancing activity and disease progression. Ear...