Burkholderia cepacia Complex Infections in Urgently Referred Neonates from Syrian Border Regions to a Hospital in Turkey: A Cross-Border Cluster

Burkholderia cepacia complex (BCC) is a rare cause of sepsis in neonates, but infections are usually severe. It can be encountered unexpectedly when adequate health care is not provided. In this study, 49 neonatal cases with blood culture-proven BCC bacteremia within the first 72 h following admissi...

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Published inChildren (Basel) Vol. 9; no. 10; p. 1566
Main Authors Cetin, Benhur Sirvan, Orman, Ayşen
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 16.10.2022
MDPI
Subjects
Antibiotics
bacteremia
Birth weight
Burkholderia cepacia complex
Cerebrospinal fluid
Congenital diseases
Hospitalization
Intensive care
Laboratories
neonate
Newborn babies
Nosocomial infections
Pathogens
Pediatrics
refugees
Sepsis
Syria
Ventilators
United States > US
Syria
Turkey
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Abstract Burkholderia cepacia complex (BCC) is a rare cause of sepsis in neonates, but infections are usually severe. It can be encountered unexpectedly when adequate health care is not provided. In this study, 49 neonatal cases with blood culture-proven BCC bacteremia within the first 72 h following admission to the neonatal intensive care unit between June 2017 and December 2018 were retrospectively analyzed in detail. All but one of the cases were born in Jarabulus, Al Bab, or Aleppo in Syria and were referred to Turkey due to urgent medical treatment needs. The rate of BCC bacteremia among the neonates transferred from across the border was 16.1% (48/297). The most common coexisting problems in the cases were multiple congenital malformations (12.2%), gastrointestinal system atresia (8.2%), and congenital heart diseases (4.1%). The median age at the time of their admission in Turkey was three days, and the median length of stay in another center before the referral was 11.5 h. The case fatality rate was 14.3%. In this study, a high rate of BCC infection and associated mortality was seen in neonates referred from cross-border regions. For centers accepting cases from conflict-affected regions, it is crucial to be careful regarding early detection of bacteremia, planning appropriate treatments, and preventing cross-contamination risks within the unit.
AbstractList Burkholderia cepacia complex (BCC) is a rare cause of sepsis in neonates, but infections are usually severe. It can be encountered unexpectedly when adequate health care is not provided. In this study, 49 neonatal cases with blood culture-proven BCC bacteremia within the first 72 h following admission to the neonatal intensive care unit between June 2017 and December 2018 were retrospectively analyzed in detail. All but one of the cases were born in Jarabulus, Al Bab, or Aleppo in Syria and were referred to Turkey due to urgent medical treatment needs. The rate of BCC bacteremia among the neonates transferred from across the border was 16.1% (48/297). The most common coexisting problems in the cases were multiple congenital malformations (12.2%), gastrointestinal system atresia (8.2%), and congenital heart diseases (4.1%). The median age at the time of their admission in Turkey was three days, and the median length of stay in another center before the referral was 11.5 h. The case fatality rate was 14.3%. In this study, a high rate of BCC infection and associated mortality was seen in neonates referred from cross-border regions. For centers accepting cases from conflict-affected regions, it is crucial to be careful regarding early detection of bacteremia, planning appropriate treatments, and preventing cross-contamination risks within the unit.
Burkholderia cepacia complex (BCC) is a rare cause of sepsis in neonates, but infections are usually severe. It can be encountered unexpectedly when adequate health care is not provided. In this study, 49 neonatal cases with blood culture-proven BCC bacteremia within the first 72 h following admission to the neonatal intensive care unit between June 2017 and December 2018 were retrospectively analyzed in detail. All but one of the cases were born in Jarabulus, Al Bab, or Aleppo in Syria and were referred to Turkey due to urgent medical treatment needs. The rate of BCC bacteremia among the neonates transferred from across the border was 16.1% (48/297). The most common coexisting problems in the cases were multiple congenital malformations (12.2%), gastrointestinal system atresia (8.2%), and congenital heart diseases (4.1%). The median age at the time of their admission in Turkey was three days, and the median length of stay in another center before the referral was 11.5 h. The case fatality rate was 14.3%. In this study, a high rate of BCC infection and associated mortality was seen in neonates referred from cross-border regions. For centers accepting cases from conflict-affected regions, it is crucial to be careful regarding early detection of bacteremia, planning appropriate treatments, and preventing cross-contamination risks within the unit.
Author Cetin, Benhur Sirvan
Orman, Ayşen
AuthorAffiliation 1 Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri 38039, Turkey
2 Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Mersin University, Mersin 33110, Turkey
AuthorAffiliation_xml – name: 1 Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri 38039, Turkey
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Snippet Burkholderia cepacia complex (BCC) is a rare cause of sepsis in neonates, but infections are usually severe. It can be encountered unexpectedly when adequate...
Burkholderia cepacia complex (BCC) is a rare cause of sepsis in neonates, but infections are usually severe. It can be encountered unexpectedly when adequate...
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StartPage 1566
SubjectTerms Antibiotics
bacteremia
Birth weight
Burkholderia cepacia complex
Cerebrospinal fluid
Congenital diseases
Hospitalization
Intensive care
Laboratories
neonate
Newborn babies
Nosocomial infections
Pathogens
Pediatrics
refugees
Sepsis
Syria
Ventilators
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Title Burkholderia cepacia Complex Infections in Urgently Referred Neonates from Syrian Border Regions to a Hospital in Turkey: A Cross-Border Cluster
URI https://www.proquest.com/docview/2728452034
https://search.proquest.com/docview/2729524601
https://pubmed.ncbi.nlm.nih.gov/PMC9600117
https://doaj.org/article/a57b9e28588b4e439e9ecae61f5a54bb
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