Standard of care vs reduced-dose chemoradiation after induction chemotherapy in HPV+ oropharyngeal carcinoma patients: The Quarterback trial

• Published in: Oral oncology Vol. 95; pp. 170 - 177
• Main Authors: Misiukiewicz, K., Gupta, V., Miles, B.A., Bakst, R., Genden, E., Selkridge, I., Surgeon, J.T., Rainey, H., Camille, N., Roy, E., Zhang, D., Ye, F., Jia, R, Moshier, E., Bonomi, M, Hwang, M., Som, P., Posner, M.R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2019
• Subjects: De-escalation; Human papillomavirus; Oropharynx cancer; Sequential therapy; Oropharynx cancer; De-escalation; Human papillomavirus; Sequential therapy

•Induction chemotherapy with TPF is safe and effective in HPV Oropharynx Cancer.•Induction Chemotherapy may be effective for chemoradiation de-escalation.•PCR testing for HPV16 and High Risk Variants in clinical trials is necessary.•Testing for p16 is insufficient for selecting patients for reduced...