Irreversible Platelet Activation Requires Protease-Activated Receptor 1-Mediated Signaling to Phosphatidylinositol Phosphates

• Published in: Molecular pharmacology Vol. 76; no. 2; pp. 301 - 313
• Main Authors: Holinstat, Michael, Preininger, Anita M, Milne, Stephen B, Hudson, W James, Brown, H Alex, Hamm, Heidi E
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.08.2009
• Subjects: Blood Platelets - drug effects; Humans; Phosphatidylinositol 3-Kinases - metabolism; Phosphatidylinositol Phosphates - metabolism; Platelet Activation - drug effects; Platelet Aggregation - drug effects; rap1 GTP-Binding Proteins - metabolism; Receptor, PAR-1 - metabolism; Signal Transduction - drug effects

Thrombin induces platelet activation through an early, reversible stage of platelet aggregation, which is followed by a later, irreversible stage of platelet aggregation. Without intervention, events leading to pathological platelet activation can result in vessel occlusion, acute coronary syndrome,...