Oral pathogens exacerbate Parkinson’s disease by promoting Th1 cell infiltration in mice

• Published in: Microbiome Vol. 11; no. 1; pp. 1 - 14
• Main Authors: Bai, Xue-Bing, Xu, Shuo, Zhou, Lu-Jun, Meng, Xiao-Qian, Li, Yu-Lin, Chen, Yan-Lin, Jiang, Yi-Han, Lin, Wen-Zhen, Chen, Bo-Yan, Du, Lin-Juan, Tian, Guo-Cai, Liu, Yan, Duan, Sheng-Zhong, Zhu, Ya-Qin
• Format: Journal Article
• Language: English
• Published: London BioMed Central 17.11.2023; BMC
• Subjects: Antibodies; Brain; Dopamine receptors; Dysbacteriosis; Experiments; Feces; Gum disease; Ileum; Immune response; Infiltration; Inflammation; Intestinal microflora; Lymph nodes; Lymphocytes T; Microorganisms; Movement disorders; MPTP; Neurodegeneration; Neurodegenerative diseases; Oral pathogens; Parkinson's disease; Pathogens; Periodontitis; rRNA 16S; T helper 1 cells; γ-Interferon; Beijing China; China

BackgroundParkinson’s disease (PD) is a common chronic neurological disorder with a high risk of disability and no cure. Periodontitis is an infectious bacterial disease occurring in periodontal supporting tissues. Studies have shown that periodontitis is closely related to PD. However, direct evide...