Metabolomics-Based Identification of Metabolic Dysfunction in Frailty

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 77; no. 12; p. 2367
• Main Authors: Westbrook, Reyhan, Zhang, Cissy, Yang, Huanle, Tian, Jing, Guo, Shenghao, Xue, Qian-Li, Walston, Jeremy, Le, Anne, Abadir, Peter M
• Format: Journal Article
• Language: English
• Published: United States 29.12.2022
• Subjects: Aged; Aging; Frail Elderly; Frailty; Glycolysis; Humans; Mass Spectrometry; Metabolomics; Glycolysis; Metabolome; Frailty; Serum; TCA cycle

Dysregulation of energy producing metabolic pathways has been observed in older adults with frailty. In this study, we used liquid chromatography-mass spectrometry technology to identify aging- and frailty-related differences in metabolites involved in glycolysis, the tricarboxylic (TCA) cycle, and...