S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to lead

• Published in: Biochimica et biophysica acta Vol. 1820; no. 1; pp. 9 - 23
• Main Authors: Mandal, Samir, Mukherjee, Sudip, Chowdhury, Kaustav Dutta, Sarkar, Avik, Basu, Kankana, Paul, Soumosish, Karmakar, Debasish, Chatterjee, Mahasweta, Biswas, Tuli, Sadhukhan, Gobinda Chandra, Sen, Gargi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 2012
• Subjects: Animals; Apoptosis; ceramides; Clotrimazole; Clotrimazole - pharmacology; confocal microscopy; Cysteine - analogs & derivatives; Cysteine - pharmacology; death; diallyl disulfide; Down-Regulation - drug effects; Erythrocyte; erythrocytes; Erythrocytes - drug effects; Erythrocytes - metabolism; Erythrocytes - pathology; fas Receptor - metabolism; Female; flow cytometry; gels; immunoblotting; Lead; Lead - toxicity; Lead Poisoning - blood; Lead Poisoning - pathology; longevity; Mass Spectrometry; Mice; Mice, Inbred BALB C; oxidative stress; plasma membrane; potassium; Reactive Oxygen Species; S allyl cysteine; scanning electron microscopy; Signal Transduction; therapeutics; toxicity; NADPH; Pb 2; Reactive oxygen species; PS; CLT; CDNB; SH group; FACS; K; BSA; FITC; TBA; NADH; DADS; LDL; Lead; OH; S allyl cysteine; NADP; GSH; SGOT; PBS; DTNB; aSMase; RBCs; GST; TBARS; DMTU; GPx; NAD; H 2O 2; Erythrocyte; WBCs; SAC; DISC; ROS; DMSA; FCS; DAS; Prx2; MiADMSA; SGPT; HNE; HPF; Clotrimazole; Apoptosis

Chronic lead (Pb 2 + ) exposure leads to the reduced lifespan of erythrocytes. Oxidative stress and K + loss accelerate Fas translocation into lipid raft microdomains inducing Fas mediated death signaling in these erythrocytes. Pathophysiological-based therapeutic strategies to combat against erythr...