Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy

• Published in: Materials & design Vol. 225; p. 111493
• Main Authors: Ding, Hong, Zhang, Xiang, Liu, Zheng, Wang, Juehan, Zhu, Ce, Chen, Qian, Huang, Yong, Ai, Youwei, Wu, Ruibang, Feng, Ganjun, Zhang, Li, Liu, Limin
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.01.2023; Elsevier
• Subjects: Intervertebral disc degeneration; Metal–organic framework; pH-response; Protocatechuic acid; Intervertebral disc degeneration; Metal–organic framework; pH-response; Protocatechuic acid

[Display omitted] •A MOFs-based intelligent nanoplatform with pH-triggered release of protocatechuic acid was constructed.•The released rate of protocatechuic acid was adaptive to the degree of disc degeneration.•The MOFs nanoplatform effectively delayed the degeneration process in rat disc degenera...