Familial Mediterranean fever in Armenian children with inflammatory bowel disease
Inflammatory bowel disease (IBD) and familial Mediterranean fever (FMF) are inflammatory diseases with complex interactions among genetic, immune, and environmental factors. FMF is a monogenic autoinflammatory disease, characterized by recurrent febrile attacks and polyserositis, and is manifested m...
Saved in:
Published in | Frontiers in pediatrics Vol. 11; p. 1288523 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
12.02.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Inflammatory bowel disease (IBD) and familial Mediterranean fever (FMF) are inflammatory diseases with complex interactions among genetic, immune, and environmental factors. FMF is a monogenic autoinflammatory disease, characterized by recurrent febrile attacks and polyserositis, and is manifested mainly in childhood. FMF is widespread in Armenia. There are reports on the concurrent occurrence of FMF and IBD.
gene mutations may have a disease-modifying effect on IBD. We have investigated the frequency of
mutations and FMF in Armenian children with IBD and their influence on the clinical course. A total of 69 untreated IBD patients under 18 years of age were enrolled: 52.1% (36) had ulcerative colitis (UC), 21.7% (15) had Crohn's disease (CD), and 26.0% (18) had unclassified colitis (IBD-U). The frequency of FMF among them was 36.2% (25/69), and
mutations were identified in 53.6% (37/69). The highest rate of
mutations and FMF was in UC patients (61.1% and 41.6% respectively). In all, 56.7% (21/37
of IBD patients with
mutations had
mutated alleles, mainly in compound heterozygous and heterozygous states. There were no associations in the group of IBD patients with coexisting FMF (25), either between any
mutation and type of IBD or coexistence of FMF. Overall, 36.0% (9/25) of them developed VEO IBD and carried mainly the
mutation. We concluded that the carrier frequency of
mutations among Armenian pediatric IBD patients was rather high (53.6%), especially for UC. It was suggested that the MEFV gene is not necessarily a susceptibility gene but most likely modifies the course of IBD.
genetic testing was recommended for Armenian pediatric IBD patients, especially for VEO UC and IBD-U, atypical IBD course, or resistance to the conventional treatment. They should also be asked for isolated febrile attacks, recurrent arthritis, and family history, even in the absence of FMF typical symptoms, to rule out FMF and its complications. |
---|---|
AbstractList | Inflammatory bowel disease (IBD) and familial Mediterranean fever (FMF) are inflammatory diseases with complex interactions among genetic, immune, and environmental factors. FMF is a monogenic autoinflammatory disease, characterized by recurrent febrile attacks and polyserositis, and is manifested mainly in childhood. FMF is widespread in Armenia. There are reports on the concurrent occurrence of FMF and IBD. MEFV gene mutations may have a disease-modifying effect on IBD. We have investigated the frequency of MEFV mutations and FMF in Armenian children with IBD and their influence on the clinical course. A total of 69 untreated IBD patients under 18 years of age were enrolled: 52.1% (36) had ulcerative colitis (UC), 21.7% (15) had Crohn's disease (CD), and 26.0% (18) had unclassified colitis (IBD-U). The frequency of FMF among them was 36.2% (25/69), and MEFV mutations were identified in 53.6% (37/69). The highest rate of MEFV mutations and FMF was in UC patients (61.1% and 41.6% respectively). In all, 56.7% (21/37) of IBD patients with MEFV mutations had M694V mutated alleles, mainly in compound heterozygous and heterozygous states. There were no associations in the group of IBD patients with coexisting FMF (25), either between any MEFV mutation and type of IBD or coexistence of FMF. Overall, 36.0% (9/25) of them developed VEO IBD and carried mainly the M694V mutation. We concluded that the carrier frequency of MEFV mutations among Armenian pediatric IBD patients was rather high (53.6%), especially for UC. It was suggested that the MEFV gene is not necessarily a susceptibility gene but most likely modifies the course of IBD. MEFV genetic testing was recommended for Armenian pediatric IBD patients, especially for VEO UC and IBD-U, atypical IBD course, or resistance to the conventional treatment. They should also be asked for isolated febrile attacks, recurrent arthritis, and family history, even in the absence of FMF typical symptoms, to rule out FMF and its complications. Inflammatory bowel disease (IBD) and familial Mediterranean fever (FMF) are inflammatory diseases with complex interactions among genetic, immune, and environmental factors. FMF is a monogenic autoinflammatory disease, characterized by recurrent febrile attacks and polyserositis, and is manifested mainly in childhood. FMF is widespread in Armenia. There are reports on the concurrent occurrence of FMF and IBD. gene mutations may have a disease-modifying effect on IBD. We have investigated the frequency of mutations and FMF in Armenian children with IBD and their influence on the clinical course. A total of 69 untreated IBD patients under 18 years of age were enrolled: 52.1% (36) had ulcerative colitis (UC), 21.7% (15) had Crohn's disease (CD), and 26.0% (18) had unclassified colitis (IBD-U). The frequency of FMF among them was 36.2% (25/69), and mutations were identified in 53.6% (37/69). The highest rate of mutations and FMF was in UC patients (61.1% and 41.6% respectively). In all, 56.7% (21/37 of IBD patients with mutations had mutated alleles, mainly in compound heterozygous and heterozygous states. There were no associations in the group of IBD patients with coexisting FMF (25), either between any mutation and type of IBD or coexistence of FMF. Overall, 36.0% (9/25) of them developed VEO IBD and carried mainly the mutation. We concluded that the carrier frequency of mutations among Armenian pediatric IBD patients was rather high (53.6%), especially for UC. It was suggested that the MEFV gene is not necessarily a susceptibility gene but most likely modifies the course of IBD. genetic testing was recommended for Armenian pediatric IBD patients, especially for VEO UC and IBD-U, atypical IBD course, or resistance to the conventional treatment. They should also be asked for isolated febrile attacks, recurrent arthritis, and family history, even in the absence of FMF typical symptoms, to rule out FMF and its complications. Inflammatory bowel disease (IBD) and familial Mediterranean fever (FMF) are inflammatory diseases with complex interactions among genetic, immune, and environmental factors. FMF is a monogenic autoinflammatory disease, characterized by recurrent febrile attacks and polyserositis, and is manifested mainly in childhood. FMF is widespread in Armenia. There are reports on the concurrent occurrence of FMF and IBD. MEFV gene mutations may have a disease-modifying effect on IBD. We have investigated the frequency of MEFV mutations and FMF in Armenian children with IBD and their influence on the clinical course. A total of 69 untreated IBD patients under 18 years of age were enrolled: 52.1% (36) had ulcerative colitis (UC), 21.7% (15) had Crohn's disease (CD), and 26.0% (18) had unclassified colitis (IBD-U). The frequency of FMF among them was 36.2% (25/69), and MEFV mutations were identified in 53.6% (37/69). The highest rate of MEFV mutations and FMF was in UC patients (61.1% and 41.6% respectively). In all, 56.7% (21/37 ) of IBD patients with MEFV mutations had M694V mutated alleles, mainly in compound heterozygous and heterozygous states. There were no associations in the group of IBD patients with coexisting FMF (25), either between any MEFV mutation and type of IBD or coexistence of FMF. Overall, 36.0% (9/25) of them developed VEO IBD and carried mainly the M694V mutation. We concluded that the carrier frequency of MEFV mutations among Armenian pediatric IBD patients was rather high (53.6%), especially for UC. It was suggested that the MEFV gene is not necessarily a susceptibility gene but most likely modifies the course of IBD. MEFV genetic testing was recommended for Armenian pediatric IBD patients, especially for VEO UC and IBD-U, atypical IBD course, or resistance to the conventional treatment. They should also be asked for isolated febrile attacks, recurrent arthritis, and family history, even in the absence of FMF typical symptoms, to rule out FMF and its complications. |
Author | Braegger, Christian Sarkisian, Tamara Amaryan, Gayane Tadevosyan, Artashes |
AuthorAffiliation | 2 Department of Pediatrics, Yerevan State Medical University , Yerevan , Armenia 3 Center of Medical Genetics and Primary Health Care , Yerevan , Armenia 4 Department of Medical Genetics, Yerevan State Medical University , Yerevan , Armenia 5 Department of Public Health and Health Care Organization, Yerevan State Medical University , Yerevan , Armenia 6 Nutrition Research Unit, Children’s University Hospital in Zürich , Zürich , Switzerland 1 National Pediatrics Center for Familial Mediterranean Fever, “Arabkir” Medical Complex-Institute of Child and Adolescent Health , Yerevan , Armenia |
AuthorAffiliation_xml | – name: 3 Center of Medical Genetics and Primary Health Care , Yerevan , Armenia – name: 4 Department of Medical Genetics, Yerevan State Medical University , Yerevan , Armenia – name: 5 Department of Public Health and Health Care Organization, Yerevan State Medical University , Yerevan , Armenia – name: 2 Department of Pediatrics, Yerevan State Medical University , Yerevan , Armenia – name: 6 Nutrition Research Unit, Children’s University Hospital in Zürich , Zürich , Switzerland – name: 1 National Pediatrics Center for Familial Mediterranean Fever, “Arabkir” Medical Complex-Institute of Child and Adolescent Health , Yerevan , Armenia |
Author_xml | – sequence: 1 givenname: Gayane surname: Amaryan fullname: Amaryan, Gayane organization: Department of Pediatrics, Yerevan State Medical University, Yerevan, Armenia – sequence: 2 givenname: Tamara surname: Sarkisian fullname: Sarkisian, Tamara organization: Department of Medical Genetics, Yerevan State Medical University, Yerevan, Armenia – sequence: 3 givenname: Artashes surname: Tadevosyan fullname: Tadevosyan, Artashes organization: Department of Public Health and Health Care Organization, Yerevan State Medical University, Yerevan, Armenia – sequence: 4 givenname: Christian surname: Braegger fullname: Braegger, Christian organization: Nutrition Research Unit, Children's University Hospital in Zürich, Zürich, Switzerland |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38410520$$D View this record in MEDLINE/PubMed |
BookMark | eNpVkU1PHCEYgImxqR_1B3hp5tjLbl9gYODUGFOriU3TRM-EgXdcDDNsYVbjvy_b3RrlAu_XA-E5IYdTmpCQcwpLzpX-OqzRLxkwvqRMKcH4ATlmTMsF4xIO35yPyFkpj1CX7kBQ8ZEccdVSEAyOye8rO4YYbGx-og8z5mwntFMz4BPmJkzNRR5xCjXjViH6jFPzHOZVrQzRjqOdU35p-vSMsfGhoC34iXwYbCx4tt9Pyf3V97vL68Xtrx83lxe3C9dSNS-o6Fo-6E4JDQ5713e885J1HryyABaBasah85ZRZJ62XGrHQVrQutM1PCU3O65P9tGscxhtfjHJBvMvkfKDsXkOLqLxAzrprOe8x1aj17L1TjsGCEI4KSvr24613vQjeofTnG18B31fmcLKPKQnQ0FpoSVUwpc9Iac_GyyzGUNxGGP9zrQphmnO2qpNbVvprtXlVErG4fUeCmar1mzVmq1as1dbZz6_feDrxH-R_C8YRqIq |
Cites_doi | 10.1007/s00431-007-0508-x 10.1053/j.gastro.2007.05.029 10.1097/MPG.0000000000002567 10.1007/s00296-017-3839-6 10.1111/j.1572-0241.2005.40810.x 10.1136/ard.2008.092031 10.5152/tjg.2021.20057 10.1111/1756-185X.12482 10.1016/S0140-6736(99)02134-0 10.1053/j.sempedsurg.2017.10.004 10.14412/1995-4484-2020-37-41 10.1155/2021/5538150 10.1002/art.1780401023 10.1016/j.jpedsurg.2018.02.023 10.1016/j.amjgastroenterol.2003.07.007 10.1186/s12969-017-0185-x 10.1097/MPG.0000000000003730 10.1007/s12328-021-01426-2 10.2147/OARRR.S252071 10.3389/fped.2020.618918 10.1007/s00296-011-1840-z 10.1186/1546-0096-11-S1-A87 10.1097/MPG.0000000000000239 10.1007/s00296-017-3848-5 10.1016/j.pcl.2005.01.005 10.1007/s00296-019-04391-9 10.3389/fimmu.2019.00763 10.1159/000502640 10.1007/s10620-010-1178-5 10.3390/jcm12093131 10.1053/j.gastro.2014.07.023 10.2174/1568010053622885 10.1007/s10620-006-3192-1 10.5217/ir.2018.00130 10.1053/berh.2000.0089 10.5606/ArchRheumatol.2018.6488 10.1097/01.md.0000152370.84628.0c 10.1097/bor.0000174210.78449.6b 10.1371/journal.pone.0007154 10.1097/MPG.0000000000003017 10.5152/tpa.2014.1998 |
ContentType | Journal Article |
Copyright | 2024 Amaryan, Sarkisian, Tadevosyan and Braegger. 2024 Amaryan, Sarkisian, Tadevosyan and Braegger. 2024 Amaryan, Sarkisian, Tadevosyan and Braegger |
Copyright_xml | – notice: 2024 Amaryan, Sarkisian, Tadevosyan and Braegger. – notice: 2024 Amaryan, Sarkisian, Tadevosyan and Braegger. 2024 Amaryan, Sarkisian, Tadevosyan and Braegger |
DBID | NPM AAYXX CITATION 7X8 5PM DOA |
DOI | 10.3389/fped.2023.1288523 |
DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic PubMed CrossRef |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 2296-2360 |
EndPage | 1288523 |
ExternalDocumentID | oai_doaj_org_article_dfec6cad33be49ed964dc9c20e055c66 10_3389_fped_2023_1288523 38410520 |
Genre | Journal Article |
GroupedDBID | 53G 5VS 9T4 AAFWJ ACGFO ACGFS ACXDI ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV DIK EMOBN GROUPED_DOAJ GX1 HYE IAO IEA IHR IHW IPNFZ KQ8 M48 M~E NPM OK1 PGMZT RIG RNS RPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c418t-15743f978590cebcb737d627d0d8a00ae0192307da21e2d14369c306a09979143 |
IEDL.DBID | RPM |
ISSN | 2296-2360 |
IngestDate | Tue Dec 17 15:16:28 EST 2024 Tue Sep 17 21:28:45 EDT 2024 Sat Oct 05 05:39:05 EDT 2024 Thu Nov 21 21:40:27 EST 2024 Sat Nov 02 12:27:08 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | genetic characteristics familial Mediterranean fever children clinical characteristics inflammatory bowel disease |
Language | English |
License | 2024 Amaryan, Sarkisian, Tadevosyan and Braegger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c418t-15743f978590cebcb737d627d0d8a00ae0192307da21e2d14369c306a09979143 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Matthew Wyatt Carroll, University of Alberta, Canada Reviewed by: Efimia Papadopoulou-Alataki, Aristotle University of Thessaloniki, Greece Abbreviations Arabkir MC- ICAH, “Arabkir” Medical Complex- Institute of Child and Adolescent Health; CD, Crohn's disease; CI, confidence interval; CMG, Center of Medical Genetics; ESPGHAN, European Society for Paedriatic Gastroenterology, Hepatology, and Nutrition; FMF, Familial Mediterranean fever; HPFS, hereditary periodic fever syndromes; IBD, Inflammatory bowel disease; IBD-U, Unclassified colitis; MEFV, Mediterranean Fever; NPC FMF, FMF National Pediatric Centre for FMF; P-value, statistical significance; PCDAI, Pediatric Crohn's Disease Activity Index; PC, polymeraze chest reaction; PUCAI, Pediatric Ulcerative Colitis Activity Index; SD, standard deviation; VEO IBD, very early-onset inflammatory bowel disease; UC, ulcerative colitis; YSMU, Yerevan State Medical University. Ozgur Kasapcopur, Istanbul University-Cerrahpasa, Türkiye |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895960/ |
PMID | 38410520 |
PQID | 2932438980 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_dfec6cad33be49ed964dc9c20e055c66 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10895960 proquest_miscellaneous_2932438980 crossref_primary_10_3389_fped_2023_1288523 pubmed_primary_38410520 |
PublicationCentury | 2000 |
PublicationDate | 2024-02-12 |
PublicationDateYYYYMMDD | 2024-02-12 |
PublicationDate_xml | – month: 02 year: 2024 text: 2024-02-12 day: 12 |
PublicationDecade | 2020 |
PublicationPlace | Switzerland |
PublicationPlace_xml | – name: Switzerland |
PublicationTitle | Frontiers in pediatrics |
PublicationTitleAlternate | Front Pediatr |
PublicationYear | 2024 |
Publisher | Frontiers Media S.A |
Publisher_xml | – sequence: 0 name: Frontiers Media S.A – name: Frontiers Media S.A |
References | Mor (B3) 2003; 98 Rigante (B6) 2006; 10 Salehzadeh (B51) 2020; 12 Uhlig (B26) 2014; 147 Villani (B18) 2009; 4 Hayrapetyan (B14) 2013; 11 Dervichian (B16) 2003 Yildiz (B50) 2020; 40 Shim (B46) 2019; 17 Ben-Chetrit (B15) 2015; 33 Livneh (B33) 2000; 14 Sahin (B20) 2021; 2021 Jain (B49) 2018; 38 Amaryan (B53) 2020; 58 Salah (B42) 2016; 19 Moran (B27) 2017; 26 Aksu (B37) 2011; 31 Uhlig (B29) 2021; 72 Ekinci R.M (B40) 2018; 33 Sarkisian (B10) 2007; 1 Stojanov (B5) 2005; 17 Torossyan (B7) 2000; 64 B8 Ozen (B44) 2009; 68 Sarkisian (B9) 2005; 4 Avagyan (B12) 2017; 20 Nambu (B28) 2021; 8 Abbara (B52) 2019; 10 (B31) 2014; 58 Uslu (B1) 2010; 55 Turner (B34) 2007; 133 Urgancı (B41) 2021; 32 Tunca (B25) 2005; 84 Giaglis (B17) 2006; 51 Beşer (B36) 2014; 49 Sari (B24) 2008; 167 Cucinotta (B30) 2023; 76 Yokoyama (B21) 2021; 14 Somi (B43) 2013; 10 Lidar (B2) 2007; 65 Kelsen (B45) 2020; 70 Cattan (B19) 2000; 355 Ozdogan (B38) 1997; 24 Padeh (B4) 2005; 52 Fidder (B23) 2005; 100 Hyams (B35) 1991; 12 Sag (B39) 2018; 38 Saito (B48) 2019; 101 Avagyan (B13) 2018; 21 Furuta (B22) 2023; 12 Livneh (B32) 1997; 40 Rialon (B47) 2018; 53 Avagyan (B11) 2017; 15 |
References_xml | – volume: 167 start-page: 391 year: 2008 ident: B24 article-title: The familial Mediterranean fever (MEFV) gene may be a modifier factor of inflammatory bowel disease in infancy publication-title: Eur J Pediatr doi: 10.1007/s00431-007-0508-x contributor: fullname: Sari – volume: 133 start-page: 423 year: 2007 ident: B34 article-title: Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.05.029 contributor: fullname: Turner – volume: 70 start-page: 389 year: 2020 ident: B45 article-title: North American society for pediatric gastroenterology, hepatology, and nutrition position paper on the evaluation and management for patients with very early-onset inflammatory bowel disease publication-title: JPGN doi: 10.1097/MPG.0000000000002567 contributor: fullname: Kelsen – volume: 38 start-page: 13 year: 2018 ident: B49 article-title: Vasculitis and vasculitis-like manifestations in monogenic autoinflammatory syndromes publication-title: Rheumatol Int doi: 10.1007/s00296-017-3839-6 contributor: fullname: Jain – volume: 100 start-page: 338 year: 2005 ident: B23 article-title: The familial Mediterranean fever (MEVF) gene as a modifier of crohn’s disease publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2005.40810.x contributor: fullname: Fidder – volume: 68 start-page: 246 year: 2009 ident: B44 article-title: Disease severity in children and adolescents with familial Mediterranean fever: a comparative study to explore environmental effects on a monogenic disease publication-title: Ann Rheum Dis doi: 10.1136/ard.2008.092031 contributor: fullname: Ozen – volume: 32 start-page: 248 year: 2021 ident: B41 article-title: Association between FMF and IBD familial Mediterranean fever mutation analysis in pediatric patients with İnflammatory bowel disease: a multicenter study publication-title: Turk J Gastroenterol doi: 10.5152/tjg.2021.20057 contributor: fullname: Urgancı – volume: 19 start-page: 806 year: 2016 ident: B42 article-title: Detection of Mediterranean fever gene mutations in Egyptian children with inflammatory bowel disease publication-title: Int J Rheum Dis doi: 10.1111/1756-185X.12482 contributor: fullname: Salah – volume: 355 start-page: 378 year: 2000 ident: B19 article-title: Inflammatory bowel disease in non-Ashkenazi Jews with familial Mediterranean fever publication-title: Lancet doi: 10.1016/S0140-6736(99)02134-0 contributor: fullname: Cattan – volume: 26 start-page: 356 year: 2017 ident: B27 article-title: Very early onset inflammatory bowel disease publication-title: Semin Pediatr Surg doi: 10.1053/j.sempedsurg.2017.10.004 contributor: fullname: Moran – volume: 58 start-page: 37 year: 2020 ident: B53 article-title: Clinical and genetic characteristics of familial Mediterranean fever-associated vaculitides in children of Armenia publication-title: Rheumatol Sci Prac doi: 10.14412/1995-4484-2020-37-41 contributor: fullname: Amaryan – volume: 10 start-page: 163 year: 2006 ident: B6 article-title: The multi-face expression of familial Mediterranean fever in the child publication-title: Eur Rev Med Pharmacol Sci contributor: fullname: Rigante – volume: 21 start-page: 34 year: 2018 ident: B13 article-title: Frequency of carrying of mutations of familial Mediterranean fever gene in Armenian male population. Issues in theoretical and clinical medicine publication-title: J Scientific Prac Med contributor: fullname: Avagyan – volume: 2021 start-page: 5538150 year: 2021 ident: B20 article-title: Evaluation of the clinical effects and frequency of MEFV gene mutation in patients with inflammatory bowel disease publication-title: Gastroenterol Res Pract doi: 10.1155/2021/5538150 contributor: fullname: Sahin – volume: 40 start-page: 1879 year: 1997 ident: B32 article-title: Criteria for the diagnosis of familial Mediterranean fever publication-title: Arthritis Rheum doi: 10.1002/art.1780401023 contributor: fullname: Livneh – volume: 65 start-page: 318 year: 2007 ident: B2 article-title: Familial Mediterranean fever: clinical, molecular and management advancements publication-title: Neth J Med contributor: fullname: Lidar – volume: 53 start-page: 964 year: 2018 ident: B47 article-title: Long-term outcomes for children with very early-onset colitis: implications for surgical management publication-title: J Pediatr Surg doi: 10.1016/j.jpedsurg.2018.02.023 contributor: fullname: Rialon – volume: 98 start-page: 2594 year: 2003 ident: B3 article-title: Abdominal and digestive system associations of familial Mediterranean fever publication-title: Am J Gastroenterol doi: 10.1016/j.amjgastroenterol.2003.07.007 contributor: fullname: Mor – volume: 15 start-page: 64 year: 2017 ident: B11 article-title: Tadevosyan a population based study of frequency of carrying FMF mutation among Armenian females publication-title: Pediatr Rheumatol doi: 10.1186/s12969-017-0185-x contributor: fullname: Avagyan – volume: 76 start-page: 590 year: 2023 ident: B30 article-title: Clinical course of very early-onset inflammatory bowel disease publication-title: J Pediatr Gastroenterol Nutr doi: 10.1097/MPG.0000000000003730 contributor: fullname: Cucinotta – volume: 14 start-page: 1103 year: 2021 ident: B21 article-title: Gastrointestinal involvement in a patient with familial Mediterranean fever mimicking Crohn’s disease: a case report publication-title: Clin J Gastroenterol doi: 10.1007/s12328-021-01426-2 contributor: fullname: Yokoyama – volume: 12 start-page: 65 year: 2020 ident: B51 article-title: Coexisting diseases in patients with familial Mediterranean fever publication-title: Open Access Rheumatol: Res Rev doi: 10.2147/OARRR.S252071 contributor: fullname: Salehzadeh – start-page: 1 year: 2003 ident: B16 article-title: Maladie periodique publication-title: Encyclopedie Medico Chirurgicale contributor: fullname: Dervichian – volume: 8 start-page: 618918 year: 2021 ident: B28 article-title: Advanced understanding of monogenic inflammatory bowel disease publication-title: Front Pediatr doi: 10.3389/fped.2020.618918 contributor: fullname: Nambu – volume: 31 start-page: 1263 year: 2011 ident: B37 article-title: Coexistence of vasculitides with familial Mediterranean fever publication-title: Rheumatol Int doi: 10.1007/s00296-011-1840-z contributor: fullname: Aksu – volume: 11 start-page: A87 year: 2013 ident: B14 article-title: Clinical-genetic investigation of FMF in Armenia publication-title: Pediatric Rheumatology doi: 10.1186/1546-0096-11-S1-A87 contributor: fullname: Hayrapetyan – volume: 10 start-page: 149 year: 2013 ident: B43 article-title: Common mutatons detection in Iranian Azeri Turk patients with UC:a case–control study publication-title: Life Science J contributor: fullname: Somi – volume: 58 start-page: 795 year: 2014 ident: B31 article-title: ESPGHAN Revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents publication-title: J Pediatr Gastroenterol Nutr doi: 10.1097/MPG.0000000000000239 – volume: 38 start-page: 137 year: 2018 ident: B39 article-title: Neonatal ulcerative colitis associated with familial Mediterranean fever: a case report publication-title: Rheumatol Int doi: 10.1007/s00296-017-3848-5 contributor: fullname: Sag – volume: 1 start-page: 33 year: 2007 ident: B10 article-title: Molecular diagnosis of familial Mediterrenean fever in Armenians publication-title: New Armenian Med J contributor: fullname: Sarkisian – volume: 52 start-page: 577 year: 2005 ident: B4 article-title: Periodic fever syndromes publication-title: Pediatr Clin N Am doi: 10.1016/j.pcl.2005.01.005 contributor: fullname: Padeh – volume: 24 start-page: 323 year: 1997 ident: B38 article-title: Vasculitis in familial Mediterranean fever publication-title: J Rheumatol contributor: fullname: Ozdogan – volume: 12 start-page: 439 year: 1991 ident: B35 article-title: Development and validation of a pediatric crohn’s disease activity index publication-title: J Pediatr Gastroenterol Nutr contributor: fullname: Hyams – volume: 40 start-page: 57 year: 2020 ident: B50 article-title: Evaluation of co-existing diseases in children with familial Mediterranean fever publication-title: Rheumatol Int doi: 10.1007/s00296-019-04391-9 contributor: fullname: Yildiz – volume: 10 start-page: 763 year: 2019 ident: B52 article-title: Association of vasculitis and familial Mediterranean fever publication-title: Front Immunol doi: 10.3389/fimmu.2019.00763 contributor: fullname: Abbara – volume: 101 start-page: 785 year: 2019 ident: B48 article-title: MEFV Gene-Related enterocolitis account for some cases diagnosed as inflammatory bowel disease unclassified publication-title: Digestion doi: 10.1159/000502640 contributor: fullname: Saito – volume: 55 start-page: 3488 year: 2010 ident: B1 article-title: The association of inflammatory bowel disease and Mediterranean fever gene (MEFV) mutations in Turkish children publication-title: Dig Dis Sci doi: 10.1007/s10620-010-1178-5 contributor: fullname: Uslu – volume: 64 start-page: 1275 year: 2000 ident: B7 article-title: Role of complex allels and gender in the susceptibility to FMF in the Armenian population publication-title: Am J Human Genetics contributor: fullname: Torossyan – volume: 12 start-page: 3131 year: 2023 ident: B22 article-title: Possible association of mutations in the MEFV gene with the intestinal phenotype of Behçet’s disease and refractoriness to treatment J publication-title: Clin. Med doi: 10.3390/jcm12093131 contributor: fullname: Furuta – volume: 147 start-page: 990 year: 2014 ident: B26 article-title: The diagnostic aproach to monogenic very early onset inflammatory bowel disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.07.023 contributor: fullname: Uhlig – volume: 4 start-page: 113 year: 2005 ident: B9 article-title: Molecular study of familial Mediterrenean fever patients in Armenia publication-title: Curr Drug Targets Inflamm Allergy doi: 10.2174/1568010053622885 contributor: fullname: Sarkisian – ident: B8 – volume: 51 start-page: 687 year: 2006 ident: B17 article-title: Increased frequency of mutation in the gene responsible for familial Mediterranean fever in a cohort of patients with ulcerative colitis: evidence for a potential disease-modifying effect? publication-title: Dig. Dis. Sci doi: 10.1007/s10620-006-3192-1 contributor: fullname: Giaglis – volume: 17 start-page: 9 year: 2019 ident: B46 article-title: Recent advance in very early-onset inflammatory bowel disease publication-title: Intest Res doi: 10.5217/ir.2018.00130 contributor: fullname: Shim – volume: 20 start-page: 58 year: 2017 ident: B12 article-title: Frequency of carrying of mutations of familial Mediterranean fever gene in Yerevan female population. Issues in theoretical and clinical medicine publication-title: J Scientific Prac Med contributor: fullname: Avagyan – volume: 14 start-page: 477 year: 2000 ident: B33 article-title: Diagnostic and treatment concerns in familial Mediterranean fever. Bailliere’s best practice & research publication-title: Clin Rheumatol doi: 10.1053/berh.2000.0089 contributor: fullname: Livneh – volume: 33 start-page: 282 year: 2018 ident: B40 article-title: The influence of concomitant disorders on disease severity of familial Mediterranean fever in children publication-title: Arch Rheumatol doi: 10.5606/ArchRheumatol.2018.6488 contributor: fullname: Ekinci R.M – volume: 84 start-page: 1 year: 2005 ident: B25 article-title: Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study publication-title: Medicine (Baltimore) doi: 10.1097/01.md.0000152370.84628.0c contributor: fullname: Tunca – volume: 17 start-page: 586 year: 2005 ident: B5 article-title: Familial autoinflammatory diseases: genetics, pathogenesis and treatment publication-title: Curr Opin Rheumatol doi: 10.1097/bor.0000174210.78449.6b contributor: fullname: Stojanov – volume: 4 start-page: e7154 year: 2009 ident: B18 article-title: Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for crohn’s disease and ulcerative colitis publication-title: PLoS One doi: 10.1371/journal.pone.0007154 contributor: fullname: Villani – volume: 33 start-page: S15 year: 2015 ident: B15 article-title: Familial Mediterranean fever in Armenia in 2015: some interesting lessons publication-title: Clin Exp Rheumatology contributor: fullname: Ben-Chetrit – volume: 72 start-page: 456 year: 2021 ident: B29 article-title: Clinical genomics for the diagnosis of monogenic forms of inflammatory bowel disease: a position paper from the paediatric IBD porto group of European society of paediatric gastroenterology, hepatology and nutrition publication-title: J Pediatr Gastroenterol Nutr doi: 10.1097/MPG.0000000000003017 contributor: fullname: Uhlig – volume: 49 start-page: 198 year: 2014 ident: B36 article-title: Association of familial Mediterranean fever in turkish children with inflammatory bowel disease publication-title: Turk Pediatri Ars doi: 10.5152/tpa.2014.1998 contributor: fullname: Beşer |
SSID | ssj0000970515 |
Score | 2.3050613 |
Snippet | Inflammatory bowel disease (IBD) and familial Mediterranean fever (FMF) are inflammatory diseases with complex interactions among genetic, immune, and... |
SourceID | doaj pubmedcentral proquest crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 1288523 |
SubjectTerms | children clinical characteristics familial Mediterranean fever genetic characteristics inflammatory bowel disease Pediatrics |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3PSx0xEA7Fg_QirVp9tpUIngpbs9lkkxxbUURQECp4C_kxi4Lue-iT_vudye6T90Tw0uMmWTZ8M2RmdibzMXbY6gatZu4qqoGqlAVZuRC6KtYixNp0MZXanIvL9uxand_omyWqL6oJG9oDD8Ad5Q5Sm0JumgjKQXatysklKUBondqh2baQS8FUOYOdIfKSIY2JUZg76mZAjUFl8xNPZKtls2KISr_-t5zM17WSS8bn9BPbGL1G_mvY7Wf2AfpNtn4x5sW32FXhr0BV4jSGUKEFgtDzDlBT-V2Pbz5QVV3PF5e3Of2AxZkONeKhZNp5nP6Fez5mbLbZ9enJn-OzaiRLqJKq7byqNfoCHcaE2okEMUXTmNxKk0W2QYgAxZcTJgdZg8zoJrUuYbwQ6Oqsw8cvbK2f9rDLeHbgrDTBOKMVhiOx0YHov01U4LJKE_ZjgZyfDT0xPMYSBLMnmD3B7EeYJ-w3YfuykNpZlwEUsh-F7N8T8oQdLCTjUf0pp4EwTp-fPHorkgjcrZiwnUFSL59qLNWwSpyxKzJc2cvqTH93W1ps18I6jcHd3v_Y_Vf2ERFRVaGR-cbW5o_P8B1dmXncL1r7D8by8yU priority: 102 providerName: Directory of Open Access Journals |
Title | Familial Mediterranean fever in Armenian children with inflammatory bowel disease |
URI | https://www.ncbi.nlm.nih.gov/pubmed/38410520 https://search.proquest.com/docview/2932438980 https://pubmed.ncbi.nlm.nih.gov/PMC10895960 https://doaj.org/article/dfec6cad33be49ed964dc9c20e055c66 |
Volume | 11 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZJDqWXkvS5zQMVeip4V5b1PCYhIRS2JNBAbkKPcbuQ9S7phvz9jLR2yIaecrRkYfHNoPnGM5oh5LuSDVrN1FY5B6oSBnhlvW-rUDMfat2GWHJzpr_UxbX4eSNvtoga7sKUpP0YZuPudj7uZn9LbuVyHidDntjkcnpaM2MlUu_JNtlG-_vMRy_nr9W5cck6hIkemJ20S8hFQXkzxtPYSN5sGKFSq_9_BPNlnuQzw3O-S971jJEer3e2R7age0_eTPuY-AdyVXpXoBrRPIYwofUB39EWUEvprMOV85xR19Hh4jbNP19xpkVtmJcoOw2LB7ilfbTmI7k-P_t9elH1jRKqKGqzqmqJPKBFf1BaFiHEoBudFNeJJeMZ81B4HNPJ8xp4QoqkbERfwedrsxYfP5GdbtHBF0KTBWu49tpqKdAVCY30ufW3DgJsEnFEfgzIueW6HoZDPyLD7DLMLsPsephH5CRj-_RiLmVdBhZ3f1wvUJdaiCr61DQBhIVklUjRRs6ASRmVGpFvg2Qcqn6OZyCMi_t_DpkKz83bDRuRz2tJPX2qMTl_leOM2ZDhxl42Z1DbSnntQbu-vn7pPnmLOIiqNI45IDuru3s4RPKyCkfF6T8qGvsII3Pxrg |
link.rule.ids | 230,314,727,780,784,864,885,2102,27924,27925,53791,53793 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3daxQxEB9qBfVF_PbU1gg-CXuXzebzsS2WU3tFoYW-hXxtPejtHfWK_76T3G7piU8-brJhw2-GzMzOLzMAH6Vo0GrGtsocqIrrxCrjXFv5mjpfq9aHws2ZncrpOf96IS52QA53YQppP_j5uLtajLv5z8KtXC3CZOCJTb7PjmqqjUDXe3IP7otGmfpOlF5OYKNy65JNEhNjMDNpVymXBWXNGM9jLVizZYZKtf5_uZh_MyXvmJ7jJ_C49xnJwWZvT2Endc_gwazPij-HH6V7BSoSyWMIFNqf5DrSJtRTMu9w5SJz6joyXN0m-fcrzrSoD4uSZyd--TtdkT5f8wLOjz-fHU2rvlVCFXit11Ut0BNoMSIUhobkg1eNipKpSKN2lLpUPDmqomN1YhGdJGkCRgsuX5w1-PgSdrtll14DiSYZzZRTRgmOwYhvhMvNv5XnyUQeRvBpQM6uNhUxLEYSGWabYbYZZtvDPILDjO3ti7mYdRlYXl_aXqQ2tinI4GLT-MRNikbyGExgNFEhgpQj-DBIxqLy54wGwri8-WXRV2G5fbumI3i1kdTtpxqdGawMZ_SWDLf2sj2D-lYKbA_69eb_l76Hh9Oz2Yk9-XL67S08Qkx4VdrIvIPd9fVN2kNXZu33i97-AUuQ9A4 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZtCqGX0ne3TxV6Kngt62FJxzbtkj42pNBAbkLPdCGrXZIN_fsdae2QLT31aMnC5puxZsbzaQahd71gYDVDagoHquEq0kZbmxrXEes6mZyv3Jz5UX94wr-eitOBVXk50Cqzd4tpPl9O8-JX5Vaul74deWLt8fygI0oLcL3bdUjtbXRHMNCyG5F63YW1LO1LtolMiMN0m9axlAalbAp7shKU7ZiiWrH_X27m32zJG-Zndh_dG_xG_GH7fg_QrZgfov35kBl_hH7UDhagTLiMAVhgg6LNOEXQVbzIsHJZeHUZj8e3cfkFCzMJdGJZc-3YrX7HczzkbB6jk9nnnweHzdAuofG8U5umE-ANJIgKhSY-Ou8kk6GnMpCgLCE2Vm-OyGBpF2kAR6nXHiIGWw7Parh8gvbyKsdnCAcdtaLSSi0Fh4DEMWFLA3DpeNSB-wl6PyJn1tuqGAaiiQKzKTCbArMZYJ6gjwXb6xtLQes6sLo4M4NYTUjR994GxlzkOgbd8-C1pyQSIXzfT9DbUTIGPoCS1QAYV1eXBvwVWlq4KzJBT7eSun4UU4XFSmFG7chw5112Z0DnapHtUcee___SN2j_-NPMfP9y9O0FuguQ8KZ2knmJ9jYXV_EVeDMb97qq7R_K4PUh |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Familial+Mediterranean+fever+in+Armenian+children+with+inflammatory+bowel+disease&rft.jtitle=Frontiers+in+pediatrics&rft.au=Amaryan%2C+Gayane&rft.au=Sarkisian%2C+Tamara&rft.au=Tadevosyan%2C+Artashes&rft.au=Braegger%2C+Christian&rft.date=2024-02-12&rft.issn=2296-2360&rft.eissn=2296-2360&rft.volume=11&rft_id=info:doi/10.3389%2Ffped.2023.1288523&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fped_2023_1288523 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2296-2360&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2296-2360&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2296-2360&client=summon |