Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF‑κB signaling

• Published in: Molecular medicine reports Vol. 23; no. 5
• Main Authors: Ma, Baitao, Wang, Xuebin, Zhang, Rui, Niu, Shuai, Rong, Zhihua , Ni, Leng, Di, Xiao, Han, Qin, Liu, Changwei
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.05.2021; D.A. Spandidos
• Subjects: Animals; Arteriosclerosis; Atherosclerosis; Atherosclerosis - chemically induced; Atherosclerosis - genetics; Atherosclerosis - pathology; Biotechnology; Cardiovascular disease; Cholesterol; Cigarette smoke; Cigarette Smoking - adverse effects; Cigarettes; Dyslipidemia; Experiments; Fluorides; Gene expression; Gene Expression Regulation - drug effects; Hep G2 Cells; Hepatocytes; Humans; Kexin; Low density lipoprotein receptors; Melatonin; NF-kappa B - genetics; NF-κB protein; Polymerase chain reaction; Proprotein Convertase 9 - genetics; Proprotein convertases; Protein-Tyrosine Kinases - genetics; Proteins; Proto-Oncogene Proteins - genetics; Reactive Oxygen Species; Receptor density; Receptors, LDL - genetics; Reverse transcription; Risk factors; Signal Transduction - drug effects; Smoking - adverse effects; Software; Subtilisin; Tumor necrosis factor-TNF; Western blotting

Cigarette smoke (CS) exposure is a risk factor for dyslipidemia and atherosclerosis. Reduced expression of low‑density lipoprotein receptor (LDLR) in hepatocytes may be one of the underlying mechanisms for these disorders. The aim of the present study was to investigate the molecular mechanism under...