Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway

• Published in: International journal of environmental research and public health Vol. 17; no. 6; p. 2042
• Main Authors: Luo, Jia, Tang, Changfa, Chen, Xiaobin, Ren, Zhanbing, Qu, Honglin, Chen, Rong, Tong, Zhen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.03.2020; MDPI
• Subjects: Aerobics; Animal cognition; Brain research; Chronic illnesses; Energy; Exercise; Fitness equipment; Gene expression; Kinases; Laboratory animals; Medical research; Mental depression; Metabolism; Musculoskeletal system; Nervous system; Pathogenesis; Physical fitness; Physiology; Proteins; Running; Swimming; exercise; AMPK/PGC-1α; chronic stress; depression

This study was to study the impact of aerobic exercises on the chronic unpredictable mild stress (CUMS) in mice, and to discuss the possible mechanism from the skeletal muscle AMPK/PGC-1α energy metabolism signaling pathway. The healthy male mice were randomly divided into Control Group (CG), Model...