Neutrophil depletion fails to improve neurologic outcome after cardiac arrest in dogs
We tested the hypothesis that polymorphonuclear leukocytes (neutrophils) contribute to morbidity and mortality in a canine model of cardiac arrest—induced central nervous system ischemia. Circulating neutrophils were depleted by administration of a neutrophil-specific sheep immune serum before a ten...
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Published in | Annals of emergency medicine Vol. 18; no. 5; pp. 517 - 522 |
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Main Authors | , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
New York, NY
Mosby, Inc
01.05.1989
Elsevier |
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Abstract | We tested the hypothesis that polymorphonuclear leukocytes (neutrophils) contribute to morbidity and mortality in a canine model of cardiac arrest—induced central nervous system ischemia. Circulating neutrophils were depleted by administration of a neutrophil-specific sheep immune serum before a ten-minute cardiac arrest in ten experimental animals. Ischemic damage measured by a neurologic deficit score in these animals was compared with that in 12 animals that received either vehicle control or nonimmune sheep serum. Animals receiving immune serum averaged 89% depletion of neutrophils immediately after resuscitation (neutrophils ± SEM: 703 ± 123/mm
3 after antiserum versus 6,384 ± 1,171/mm
3 before immune serum) and 70% depletion over the first three hours after resuscitation. Neurologic deficit scores assessed at one, two, six, 12, and 24 hours after arrest did not vary between depleted dogs and controls. Overall survival time in neutrophil-depleted dogs was less than in controls (15.5 ± 1.3 versus 19.5 ± 1.3 hours;
P = .04). These results suggest that neutrophils may not contribute to clinically important central nervous system dysfunction after resuscitation from a ten-minute cardiac arrest. |
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AbstractList | We tested the hypothesis that polymorphonuclear leukocytes (neutrophils) contribute to morbidity and mortality in a canine model of cardiac arrest-induced central nervous system ischemia. Circulating neutrophils were depleted by administration of a neutrophil-specific sheep immune serum before a ten-minute cardiac arrest in ten experimental animals. Ischemic damage measured by a neurologic deficit score in these animals was compared with that in 12 animals that received either vehicle control or nonimmune sheep serum. Animals receiving immune serum averaged 89% depletion of neutrophils immediately after resuscitation (neutrophils +/- SEM: 703 +/- 123/mm3 after antiserum versus 6,384 +/- 1,171/mm3 before immune serum) and 70% depletion over the first three hours after resuscitation. Neurologic deficit scores assessed at one, two, six, 12, and 24 hours after arrest did not vary between depleted dogs and controls. Overall survival time in neutrophil-depleted dogs was less than in controls (15.5 +/- 1.3 versus 19.5 +/- 1.3 hours; P = .04). These results suggest that neutrophils may not contribute to clinically important central nervous system dysfunction after resuscitation from a ten-minute cardiac arrest. We tested the hypothesis that polymorphonuclear leukocytes (neutrophils) contribute to morbidity and mortality in a canine model of cardiac arrest—induced central nervous system ischemia. Circulating neutrophils were depleted by administration of a neutrophil-specific sheep immune serum before a ten-minute cardiac arrest in ten experimental animals. Ischemic damage measured by a neurologic deficit score in these animals was compared with that in 12 animals that received either vehicle control or nonimmune sheep serum. Animals receiving immune serum averaged 89% depletion of neutrophils immediately after resuscitation (neutrophils ± SEM: 703 ± 123/mm 3 after antiserum versus 6,384 ± 1,171/mm 3 before immune serum) and 70% depletion over the first three hours after resuscitation. Neurologic deficit scores assessed at one, two, six, 12, and 24 hours after arrest did not vary between depleted dogs and controls. Overall survival time in neutrophil-depleted dogs was less than in controls (15.5 ± 1.3 versus 19.5 ± 1.3 hours; P = .04). These results suggest that neutrophils may not contribute to clinically important central nervous system dysfunction after resuscitation from a ten-minute cardiac arrest. |
Author | Schott, Robert J Natale, JoAnne E Ressler, Steven W Burney, Richard E D'Alecy, Louis G |
Author_xml | – sequence: 1 givenname: Robert J surname: Schott fullname: Schott, Robert J organization: Department of Surgery, The University of Michigan, Ann Arbor, USA – sequence: 2 givenname: JoAnne E surname: Natale fullname: Natale, JoAnne E organization: Department of Physiology, The University of Michigan, Ann Arbor, USA – sequence: 3 givenname: Steven W surname: Ressler fullname: Ressler, Steven W organization: Department of Physiology, The University of Michigan, Ann Arbor, USA – sequence: 4 givenname: Richard E surname: Burney fullname: Burney, Richard E organization: Department of Surgery, The University of Michigan, Ann Arbor, USA – sequence: 5 givenname: Louis G surname: D'Alecy fullname: D'Alecy, Louis G organization: Department of Surgery, The University of Michigan, Ann Arbor, USA |
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Cites_doi | 10.1161/01.RES.61.1.20 10.1093/infdis/152.4.690 10.1056/NEJM198007033030109 10.1016/0002-8703(86)90461-8 10.1016/0022-1759(74)90109-4 10.1161/01.STR.17.2.246 10.1016/0300-9572(86)90064-X 10.1038/289646a0 10.1161/01.CIR.67.5.1016 |
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Keywords | neutrophils, ischemia, central nervous system Fissipedia Intensive cardiocirculatory care Carnivora Vertebrata Cardiocirculatory arrest Experimental disease Mammalia Prognosis Encephalopathy Dog Neutropenia |
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References_xml | – volume: 251 start-page: H314 year: 1986 end-page: H322 ident: bib4 article-title: Role of leukocytes in response to acute myocardial ischemia and reflow in dogs publication-title: Am J Physiol contributor: fullname: Morris – volume: 5 start-page: 249 year: 1974 end-page: 252 ident: bib10 article-title: Single-step separation of red blood cells, granulocytes and mononuclear cells on discontinuous density gradients of Ficoll-Hypaque publication-title: J Immunol Meth contributor: fullname: Abrahams – volume: 14 start-page: 199 year: 1986 end-page: 212 ident: bib14 article-title: Ibuprofen improves survival and neurologic outcome after resuscitation from cardiac arrest publication-title: Resuscitation contributor: fullname: Zelenock – volume: 289 start-page: 646 year: 1981 end-page: 650 ident: bib5 article-title: Control of vascular permeability by polymorphonuclear leukocytes in inflammation publication-title: Nature contributor: fullname: Williams – volume: 67 start-page: 1016 year: 1983 end-page: 1023 ident: bib8 article-title: Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog publication-title: Circulation contributor: fullname: Kunkel – volume: 303 start-page: 27 year: 1980 end-page: 34 ident: bib3 article-title: Release of inflammatory mediators from stimulated neutrophils publication-title: N Engl J Med contributor: fullname: Korchak – volume: 17 start-page: 246 year: 1986 end-page: 253 ident: bib12 article-title: Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period publication-title: Stroke contributor: fullname: Tanishma – volume: 116 start-page: 223 year: 1984 end-page: 233 ident: bib16 article-title: Rat neutrophil activation and effects of lipoxygenase and cyclooxygenase inhibitors publication-title: Am J Pathol contributor: fullname: Johnson – volume: 76 start-page: IV year: 1987 end-page: 201 ident: bib7 article-title: The no-reflow phenomenon: Time course, spatial distribution and the effect of leukopenia in dogs after temporary coronary artery occlusion publication-title: Circulation contributor: fullname: Rousseau – volume: 112 start-page: 682 year: 1986 end-page: 690 ident: bib9 article-title: Reduction of myocardial infarct size by neutrophil depletion: Effect of duration of occlusion publication-title: Am Heart J contributor: fullname: Hook – volume: 152 start-page: 690 year: 1985 end-page: 694 ident: bib15 article-title: Effects of the newer nonsteroidal anti-inflammatory agents, ibuprofen, fenoprofen and sulindac, on neutrophil adherence publication-title: J Infect Dis contributor: fullname: Pearlman – volume: 61 start-page: 20 year: 1987 end-page: 28 ident: bib6 article-title: Granulocytes cause reperfusion ventricular dysfunction after 15-minute ischemia in the dog publication-title: Circ Res contributor: fullname: Covell – volume: 37 start-page: 249 year: 1987 ident: bib13 article-title: Leukopenia ameliorates multifocal brain ischemia publication-title: Neurology contributor: fullname: Francis – volume: 46 start-page: 2402 year: 1987 end-page: 2406 ident: bib1 article-title: Oxygen-derived radicals: A link between reperfusion injury and inflammation publication-title: Fed Proc contributor: fullname: McCord – volume: 107 start-page: 397 year: 1982 end-page: 418 ident: bib2 article-title: Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions publication-title: Am J Pathol contributor: fullname: Ward – volume: 100 start-page: 505 year: 1986 end-page: 511 ident: bib11 article-title: Dextrose containing intravenous fluids impairs outcome and increases death after eight minutes of cardiac arrest and resuscitation in dogs publication-title: Surgery contributor: fullname: Barton – volume: 61 start-page: 20 year: 1987 ident: 10.1016/S0196-0644(89)80836-4_bib6 article-title: Granulocytes cause reperfusion ventricular dysfunction after 15-minute ischemia in the dog publication-title: Circ Res doi: 10.1161/01.RES.61.1.20 contributor: fullname: Engler – volume: 152 start-page: 690 year: 1985 ident: 10.1016/S0196-0644(89)80836-4_bib15 article-title: Effects of the newer nonsteroidal anti-inflammatory agents, ibuprofen, fenoprofen and sulindac, on neutrophil adherence publication-title: J Infect Dis doi: 10.1093/infdis/152.4.690 contributor: fullname: Venezio – volume: 303 start-page: 27 year: 1980 ident: 10.1016/S0196-0644(89)80836-4_bib3 article-title: Release of inflammatory mediators from stimulated neutrophils publication-title: N Engl J Med doi: 10.1056/NEJM198007033030109 contributor: fullname: Weissmann – volume: 112 start-page: 682 year: 1986 ident: 10.1016/S0196-0644(89)80836-4_bib9 article-title: Reduction of myocardial infarct size by neutrophil depletion: Effect of duration of occlusion publication-title: Am Heart J doi: 10.1016/0002-8703(86)90461-8 contributor: fullname: Jolly – volume: 37 start-page: 249 year: 1987 ident: 10.1016/S0196-0644(89)80836-4_bib13 article-title: Leukopenia ameliorates multifocal brain ischemia publication-title: Neurology contributor: fullname: Dutka – volume: 251 start-page: H314 year: 1986 ident: 10.1016/S0196-0644(89)80836-4_bib4 article-title: Role of leukocytes in response to acute myocardial ischemia and reflow in dogs publication-title: Am J Physiol contributor: fullname: Engler – volume: 46 start-page: 2402 year: 1987 ident: 10.1016/S0196-0644(89)80836-4_bib1 article-title: Oxygen-derived radicals: A link between reperfusion injury and inflammation contributor: fullname: McCord – volume: 107 start-page: 397 year: 1982 ident: 10.1016/S0196-0644(89)80836-4_bib2 article-title: Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions publication-title: Am J Pathol contributor: fullname: Fantone – volume: 5 start-page: 249 year: 1974 ident: 10.1016/S0196-0644(89)80836-4_bib10 article-title: Single-step separation of red blood cells, granulocytes and mononuclear cells on discontinuous density gradients of Ficoll-Hypaque publication-title: J Immunol Meth doi: 10.1016/0022-1759(74)90109-4 contributor: fullname: English – volume: 100 start-page: 505 year: 1986 ident: 10.1016/S0196-0644(89)80836-4_bib11 article-title: Dextrose containing intravenous fluids impairs outcome and increases death after eight minutes of cardiac arrest and resuscitation in dogs publication-title: Surgery contributor: fullname: D'Alecy – volume: 17 start-page: 246 year: 1986 ident: 10.1016/S0196-0644(89)80836-4_bib12 article-title: Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period publication-title: Stroke doi: 10.1161/01.STR.17.2.246 contributor: fullname: Hallenbeck – volume: 116 start-page: 223 year: 1984 ident: 10.1016/S0196-0644(89)80836-4_bib16 article-title: Rat neutrophil activation and effects of lipoxygenase and cyclooxygenase inhibitors publication-title: Am J Pathol contributor: fullname: Ward – volume: 14 start-page: 199 year: 1986 ident: 10.1016/S0196-0644(89)80836-4_bib14 article-title: Ibuprofen improves survival and neurologic outcome after resuscitation from cardiac arrest publication-title: Resuscitation doi: 10.1016/0300-9572(86)90064-X contributor: fullname: Kuhn – volume: 289 start-page: 646 year: 1981 ident: 10.1016/S0196-0644(89)80836-4_bib5 article-title: Control of vascular permeability by polymorphonuclear leukocytes in inflammation publication-title: Nature doi: 10.1038/289646a0 contributor: fullname: Wedmore – volume: 76 start-page: IV issue: Suppl IV year: 1987 ident: 10.1016/S0196-0644(89)80836-4_bib7 article-title: The no-reflow phenomenon: Time course, spatial distribution and the effect of leukopenia in dogs after temporary coronary artery occlusion publication-title: Circulation contributor: fullname: de Lorgeril – volume: 67 start-page: 1016 year: 1983 ident: 10.1016/S0196-0644(89)80836-4_bib8 article-title: Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog publication-title: Circulation doi: 10.1161/01.CIR.67.5.1016 contributor: fullname: Romson |
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SubjectTerms | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Central Nervous System - blood supply Dogs Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Heart Arrest - blood Heart Arrest - complications Heart Arrest - physiopathology Immune Sera - administration & dosage Intensive care medicine Ischemia - etiology Ischemia - physiopathology Medical sciences Neutropenia - physiopathology Neutrophils - immunology Neutrophils - physiology neutrophils, ischemia, central nervous system |
Title | Neutrophil depletion fails to improve neurologic outcome after cardiac arrest in dogs |
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