Protective effect of apoptosis signal-regulating kinase 1 inhibitor against mice liver injury

• Published in: Asian Pacific journal of tropical medicine Vol. 9; no. 3; pp. 283 - 287
• Main Authors: He, Ping, Zeng, Bo, Zhang, Xiao-Li, Fang, Dian-Liang, Zhou, Xia-Qia, Wan, Ke-Qiang, Tian, Wen-Guang
• Format: Journal Article
• Language: English
• Published: India Elsevier B.V 01.03.2016
• Subjects: Acetaminophen; Apoptosis signal-regulating kinase 1; JNK; Liver injury; Apoptosis signal-regulating kinase 1; Acetaminophen; JNK; Liver injury

To explore the protective effect and its molecular mechanism of apoptosis signal-regulating kinase 1 (ASK1) inhibitor (GS-459679) on acetaminophen-induced liver injury in mice. The model of liver injury was established by administration of acetaminophen (APAP) (300 mg/kg, i.p.) on C57BL/6 mice. Fort...