Regulation of epithelial‐to‐mesenchymal transition in hypoxia by the HIF‐1α network

• Published in: FEBS letters Vol. 596; no. 3; pp. 338 - 349
• Main Authors: Wang, Hang‐Yu, Zhang, Xiao‐Peng, Wang, Wei
• Format: Journal Article
• Language: English
• Published: England 01.02.2022
• Subjects: Cell Hypoxia; Epithelial-Mesenchymal Transition - genetics; epithelial‐to‐mesenchymal transition; Feedback, Physiological; HIF‐1α network; Humans; hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; intermediate state; metastasis; MicroRNAs - genetics; MicroRNAs - metabolism; Models, Biological; Nuclear Proteins; positive feedback loop; Snail Family Transcription Factors - genetics; Snail Family Transcription Factors - metabolism; topology; Twist-Related Protein 1 - genetics; Twist-Related Protein 1 - metabolism; HIF-1α network; intermediate state; positive feedback loop; topology; epithelial-to-mesenchymal transition

Epithelial‐to‐mesenchymal transition (EMT) plays a significant role in cancer metastasis. A series of models have focused on EMT regulation by TGF‐β network. However, how EMT is regulated under hypoxia is less understood. We developed a model of HIF‐1α network to explore the potential link between E...