Norepinephrine inhibits cell cycle re‐entry of neonatal rat ventricular cardiomyocytes characterized by the absence of de novo nestin expression

• Published in: Physiological reports Vol. 13; no. 15; pp. e70488 - n/a
• Main Authors: Aubry, Adrien, Kebbe, Mariana, Al‐Katat, Aya, Villeneuve, Louis, Calderone, Angelino
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2025; John Wiley and Sons Inc; Wiley
• Subjects: Adrenergic receptors; Animals; Animals, Newborn; Antibodies; Cardiomyocytes; Cell cycle; Cell Cycle - drug effects; cell cycle re‐entry; Cells, Cultured; Down-regulation; Fibroblasts; Heart; Heart Ventricles - cytology; Heart Ventricles - drug effects; Heart Ventricles - metabolism; Imidazoles - pharmacology; Isoproterenol - pharmacology; Kinases; Laboratories; MAP kinase; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; neonatal rat ventricular cardiomyocytes; Neonates; Nestin; Nestin - genetics; Nestin - metabolism; Norepinephrine; Norepinephrine - pharmacology; Original; p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases - metabolism; p38α/β MAPK; Phosphorylation; PKC isoforms; Protein kinase C; Proteins; Pyridines; Rats; Rats, Sprague-Dawley; Regular Manuscript; Rodents; Selenium; siRNA; Ventricle; β1/2‐adrenergic receptors; mM; p38α/β MAPK; neonatal rat ventricular cardiomyocytes; cell cycle re‐entry; nestin; β1/2‐adrenergic receptors; PKC isoforms

The p38α/β MAPK inhibitor SB203580 in the presence of a phorbol ester (protein kinase C activator) induced cell cycle re‐entry of two subpopulations of neonatal rat ventricular cardiomyocytes (NNVMs) distinguished by the absence or de novo nestin expression. Recent studies have reported that the β‐a...