Cyclooxygenase‐2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer

• Published in: International journal of cancer Vol. 126; no. 2; pp. 382 - 394
• Main Authors: Uddin, Shahab, Ahmed, Maqbool, Hussain, Azhar, Assad, Lina, Al‐Dayel, Fouad, Bavi, Prashant, Al‐Kuraya, Khawla S., Munkarah, Adnan
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.01.2010; Wiley Subscription Services, Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT; AKT protein; Animals; Apoptosis; Apoptosis - drug effects; Aspirin; Aspirin - pharmacology; Biomarkers; Blotting, Western; Cancer; Cell Line, Tumor; Cell Survival - drug effects; Cox‐2; Cyclooxygenase 2 - genetics; Cyclooxygenase 2 - metabolism; Cyclooxygenase 2 Inhibitors - pharmacology; Dose-Response Relationship, Drug; Epithelial Cells - pathology; Female; Gene silencing; Humans; Immunohistochemistry; Inhibitors; Kinases; Medical research; Mice; Mice, Nude; Middle Aged; Molecular modelling; Nitrobenzenes - pharmacology; Ovarian cancer; Ovarian Neoplasms - enzymology; Ovarian Neoplasms - pathology; Ovarian Neoplasms - prevention & control; Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Prostaglandin endoperoxide synthase; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - metabolism; RNA Interference; Signal Transduction - drug effects; siRNA; Sulfonamides - pharmacology; Therapeutic targets; Tissue Array Analysis; Xenograft Model Antitumor Assays

Cyclooxygenase‐2 (COX‐2) expression contributes to tumor growth and invasion in epithelial ovarian cancer (EOC). COX‐2 inhibitors exhibit important anticarcinogenic potential against EOC, but the molecular mechanisms underlying this effect and relation with PI3‐kinase/AKT signaling remain the subjec...