Novel Application of Natural Anisole Compounds as Enhancers for Transdermal Delivery of Ligustrazine
To improve the transdermal delivery of ligustrazine, Foeniculum vulgare food origin anisole compounds were employed as promoters. Transdermal fluxes of ligustrazine were determined by Franz-type diffusion cells. Fourier transform-infrared (FT-IR) spectra were used to detect the biophysical changes o...
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Published in | The American journal of Chinese medicine (1979) Vol. 43; no. 6; p. 1231 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Singapore
2015
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Abstract | To improve the transdermal delivery of ligustrazine, Foeniculum vulgare food origin anisole compounds were employed as promoters. Transdermal fluxes of ligustrazine were determined by Franz-type diffusion cells. Fourier transform-infrared (FT-IR) spectra were used to detect the biophysical changes of the stratum corneum and to explore the mechanism of permeation enhancement. A scanning electron microscope (SEM) was used to monitor the morphological changes of the skin. Among the three anisoles, anisic acid increased the penetration flux of ligustrazine significantly. The ligustrazine flux with anisic acid (11.9 μg/cm(2)/h) was higher than that any other group (p < 0.05). Spectra observations revealed that these anisole enhancers were able to disturb and extract the stratum corneum lipids. In addition, apparent density was used to describe the desquamation extent of the scutella. Multiple mechanisms are involved in the permeation enhancement of ligustrazine, including disturbing and extracting stratum corneum lipid, forming a competitive hydrogen bond. All data suggested that anisole compounds could be a group of safe and active penetration enhancers for transdermal delivery of ligustrazine. |
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AbstractList | To improve the transdermal delivery of ligustrazine, Foeniculum vulgare food origin anisole compounds were employed as promoters. Transdermal fluxes of ligustrazine were determined by Franz-type diffusion cells. Fourier transform-infrared (FT-IR) spectra were used to detect the biophysical changes of the stratum corneum and to explore the mechanism of permeation enhancement. A scanning electron microscope (SEM) was used to monitor the morphological changes of the skin. Among the three anisoles, anisic acid increased the penetration flux of ligustrazine significantly. The ligustrazine flux with anisic acid (11.9 μg/cm(2)/h) was higher than that any other group (p < 0.05). Spectra observations revealed that these anisole enhancers were able to disturb and extract the stratum corneum lipids. In addition, apparent density was used to describe the desquamation extent of the scutella. Multiple mechanisms are involved in the permeation enhancement of ligustrazine, including disturbing and extracting stratum corneum lipid, forming a competitive hydrogen bond. All data suggested that anisole compounds could be a group of safe and active penetration enhancers for transdermal delivery of ligustrazine. |
Author | Wang, Chong-Zhi Zhang, Chun-Feng Wang, Jiao-Ying Li, Hui He, Xin Li, Fei Zhang, Run-Qi Yuan, Chun-Su Zhang, Wen-Jun Yang, Zhong-Lin |
Author_xml | – sequence: 1 givenname: Wen-Jun surname: Zhang fullname: Zhang, Wen-Jun organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, China – sequence: 2 givenname: Jiao-Ying surname: Wang fullname: Wang, Jiao-Ying organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, China – sequence: 3 givenname: Hui surname: Li fullname: Li, Hui organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, China – sequence: 4 givenname: Xin surname: He fullname: He, Xin organization: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210000, China – sequence: 5 givenname: Run-Qi surname: Zhang fullname: Zhang, Run-Qi organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, China – sequence: 6 givenname: Chun-Feng surname: Zhang fullname: Zhang, Chun-Feng organization: Tang Center of Herbal Medicine and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA – sequence: 7 givenname: Fei surname: Li fullname: Li, Fei organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, China – sequence: 8 givenname: Zhong-Lin surname: Yang fullname: Yang, Zhong-Lin organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, China – sequence: 9 givenname: Chong-Zhi surname: Wang fullname: Wang, Chong-Zhi organization: Tang Center of Herbal Medicine and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA – sequence: 10 givenname: Chun-Su surname: Yuan fullname: Yuan, Chun-Su organization: Tang Center of Herbal Medicine and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA |
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Keywords | Transdermal Mechanism Ligustrazine Stratum Corneum Apparent Density Anisole Enhancers |
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Snippet | To improve the transdermal delivery of ligustrazine, Foeniculum vulgare food origin anisole compounds were employed as promoters. Transdermal fluxes of... |
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SubjectTerms | Administration, Cutaneous Animals Anisoles - chemistry Drug Carriers - chemistry Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacokinetics Foeniculum - chemistry Ligusticum - chemistry Skin - drug effects Swine |
Title | Novel Application of Natural Anisole Compounds as Enhancers for Transdermal Delivery of Ligustrazine |
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