Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes
Background The Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric organ donors with various risk levels for type 1 diabetes (T1D). These biospecimens are available to investigators for collaborative studies...
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| Published in | Diabetes/metabolism research and reviews Vol. 28; no. 7; pp. 608 - 617 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.10.2012
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Background
The Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric organ donors with various risk levels for type 1 diabetes (T1D). These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis.
Research design and methods
Organ donors included T1D patients (new onset to long term), non‐diabetic autoantibody‐positive subjects, non‐diabetic controls and individuals with disorders relevant to β‐cell function. Pancreas recovery and transport met transplant‐grade criteria. Additional samples recovered included serum, whole blood, spleen and pancreatic and non‐pancreatic lymph nodes. Biospecimens were processed for cryopreserved cells, fixed paraffin and fresh frozen blocks and snap frozen samples. T1D autoantibodies, C‐peptide levels and high‐resolution HLA genotyping for risk alleles were also determined.
Results
Over 160 donors have been enrolled (ages of 1 day to >90 years). Standard operating procedures were established along with a quality management system. Donor demographics, laboratory assays and histopathological characterizations were shared through an open online informatics system. Biospecimens were distributed to more than 60 investigators.
Conclusions
The nPOD programme provides access to high quality biospecimens without cost to investigators. Collaborations and open data sharing are emphasized to maximize research potential of each donor. On the basis of initial successes, the nPOD programme is expanding to recover additional organs relevant to T1D pathogenesis and complications from European countries (PanFin network). Copyright © 2012 John Wiley & Sons, Ltd. |
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| AbstractList | The Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric organ donors with various risk levels for type 1 diabetes (T1D). These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis.BACKGROUNDThe Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric organ donors with various risk levels for type 1 diabetes (T1D). These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis.Organ donors included T1D patients (new onset to long term), non-diabetic autoantibody-positive subjects, non-diabetic controls and individuals with disorders relevant to β-cell function. Pancreas recovery and transport met transplant-grade criteria. Additional samples recovered included serum, whole blood, spleen and pancreatic and non-pancreatic lymph nodes. Biospecimens were processed for cryopreserved cells, fixed paraffin and fresh frozen blocks and snap frozen samples. T1D autoantibodies, C-peptide levels and high-resolution HLA genotyping for risk alleles were also determined.RESEARCH DESIGN AND METHODSOrgan donors included T1D patients (new onset to long term), non-diabetic autoantibody-positive subjects, non-diabetic controls and individuals with disorders relevant to β-cell function. Pancreas recovery and transport met transplant-grade criteria. Additional samples recovered included serum, whole blood, spleen and pancreatic and non-pancreatic lymph nodes. Biospecimens were processed for cryopreserved cells, fixed paraffin and fresh frozen blocks and snap frozen samples. T1D autoantibodies, C-peptide levels and high-resolution HLA genotyping for risk alleles were also determined.Over 160 donors have been enrolled (ages of 1 day to >90 years). Standard operating procedures were established along with a quality management system. Donor demographics, laboratory assays and histopathological characterizations were shared through an open online informatics system. Biospecimens were distributed to more than 60 investigators.RESULTSOver 160 donors have been enrolled (ages of 1 day to >90 years). Standard operating procedures were established along with a quality management system. Donor demographics, laboratory assays and histopathological characterizations were shared through an open online informatics system. Biospecimens were distributed to more than 60 investigators.The nPOD programme provides access to high quality biospecimens without cost to investigators. Collaborations and open data sharing are emphasized to maximize research potential of each donor. On the basis of initial successes, the nPOD programme is expanding to recover additional organs relevant to T1D pathogenesis and complications from European countries (PanFin network).CONCLUSIONSThe nPOD programme provides access to high quality biospecimens without cost to investigators. Collaborations and open data sharing are emphasized to maximize research potential of each donor. On the basis of initial successes, the nPOD programme is expanding to recover additional organs relevant to T1D pathogenesis and complications from European countries (PanFin network). The Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric organ donors with various risk levels for type 1 diabetes (T1D). These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis. Organ donors included T1D patients (new onset to long term), non-diabetic autoantibody-positive subjects, non-diabetic controls and individuals with disorders relevant to β-cell function. Pancreas recovery and transport met transplant-grade criteria. Additional samples recovered included serum, whole blood, spleen and pancreatic and non-pancreatic lymph nodes. Biospecimens were processed for cryopreserved cells, fixed paraffin and fresh frozen blocks and snap frozen samples. T1D autoantibodies, C-peptide levels and high-resolution HLA genotyping for risk alleles were also determined. Over 160 donors have been enrolled (ages of 1 day to >90 years). Standard operating procedures were established along with a quality management system. Donor demographics, laboratory assays and histopathological characterizations were shared through an open online informatics system. Biospecimens were distributed to more than 60 investigators. The nPOD programme provides access to high quality biospecimens without cost to investigators. Collaborations and open data sharing are emphasized to maximize research potential of each donor. On the basis of initial successes, the nPOD programme is expanding to recover additional organs relevant to T1D pathogenesis and complications from European countries (PanFin network). Background The Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric organ donors with various risk levels for type 1 diabetes (T1D). These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis. Research design and methods Organ donors included T1D patients (new onset to long term), non‐diabetic autoantibody‐positive subjects, non‐diabetic controls and individuals with disorders relevant to β‐cell function. Pancreas recovery and transport met transplant‐grade criteria. Additional samples recovered included serum, whole blood, spleen and pancreatic and non‐pancreatic lymph nodes. Biospecimens were processed for cryopreserved cells, fixed paraffin and fresh frozen blocks and snap frozen samples. T1D autoantibodies, C‐peptide levels and high‐resolution HLA genotyping for risk alleles were also determined. Results Over 160 donors have been enrolled (ages of 1 day to >90 years). Standard operating procedures were established along with a quality management system. Donor demographics, laboratory assays and histopathological characterizations were shared through an open online informatics system. Biospecimens were distributed to more than 60 investigators. Conclusions The nPOD programme provides access to high quality biospecimens without cost to investigators. Collaborations and open data sharing are emphasized to maximize research potential of each donor. On the basis of initial successes, the nPOD programme is expanding to recover additional organs relevant to T1D pathogenesis and complications from European countries (PanFin network). Copyright © 2012 John Wiley & Sons, Ltd. |
| Author | Campbell-Thompson, Martha Staeva, Teodora Schatz, Desmond Rowe, Patrick Atkinson, Mark Albanese-O'Neill, Anastasia Crawford, James Eisenbarth, George Moraski, Jayne Gianani, Roberto Nierras, Concepcion Pugliese, Alberto Wasserfall, Clive Kaddis, John |
| AuthorAffiliation | 2 City of Hope, Los Angeles, CA 3 Juvenile Diabetes Research Foundation, New York, NY 1 Department of Pathology, Immunology, & Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 5 North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 4 Barbara Davis Center for Diabetes, University of Colorado, Denver, CO 6 Department of Pediatrics, University of Florida, Gainesville, FL 7 Diabetes Research Institute, University of Miami, Miami, FL |
| AuthorAffiliation_xml | – name: 6 Department of Pediatrics, University of Florida, Gainesville, FL – name: 7 Diabetes Research Institute, University of Miami, Miami, FL – name: 3 Juvenile Diabetes Research Foundation, New York, NY – name: 1 Department of Pathology, Immunology, & Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL – name: 2 City of Hope, Los Angeles, CA – name: 4 Barbara Davis Center for Diabetes, University of Colorado, Denver, CO – name: 5 North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY |
| Author_xml | – sequence: 1 givenname: Martha surname: Campbell-Thompson fullname: Campbell-Thompson, Martha email: Martha Campbell-Thompson, Department of Pathology, Immunology and Laboratory Medicine, 1600 SW Archer Rd, University of Florida, Gainesville, FL 32610-0275, USA., mct@ufl.edu organization: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, FL, Gainesville, USA – sequence: 2 givenname: Clive surname: Wasserfall fullname: Wasserfall, Clive organization: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, FL, Gainesville, USA – sequence: 3 givenname: John surname: Kaddis fullname: Kaddis, John organization: City of Hope, CA, Los Angeles, USA – sequence: 4 givenname: Anastasia surname: Albanese-O'Neill fullname: Albanese-O'Neill, Anastasia organization: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, FL, Gainesville, USA – sequence: 5 givenname: Teodora surname: Staeva fullname: Staeva, Teodora organization: Juvenile Diabetes Research Foundation, NY, New York, USA – sequence: 6 givenname: Concepcion surname: Nierras fullname: Nierras, Concepcion organization: Juvenile Diabetes Research Foundation, NY, New York, USA – sequence: 7 givenname: Jayne surname: Moraski fullname: Moraski, Jayne organization: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, FL, Gainesville, USA – sequence: 8 givenname: Patrick surname: Rowe fullname: Rowe, Patrick organization: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, FL, Gainesville, USA – sequence: 9 givenname: Roberto surname: Gianani fullname: Gianani, Roberto organization: Barbara Davis Center for Diabetes, University of Colorado, CO, Denver, USA – sequence: 10 givenname: George surname: Eisenbarth fullname: Eisenbarth, George organization: Barbara Davis Center for Diabetes, University of Colorado, CO, Denver, USA – sequence: 11 givenname: James surname: Crawford fullname: Crawford, James organization: Hofstra North Shore-LIJ, School of Medicine, NY, Uniondale, USA – sequence: 12 givenname: Desmond surname: Schatz fullname: Schatz, Desmond organization: Department of Pediatrics, University of Florida, FL, Gainesville, USA – sequence: 13 givenname: Alberto surname: Pugliese fullname: Pugliese, Alberto organization: Diabetes Research Institute, University of Miami, FL, Miami, USA – sequence: 14 givenname: Mark surname: Atkinson fullname: Atkinson, Mark organization: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22585677$$D View this record in MEDLINE/PubMed |
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| PublicationTitleAlternate | Diabetes Metab Res Rev |
| PublicationYear | 2012 |
| Publisher | John Wiley & Sons, Ltd |
| Publisher_xml | – name: John Wiley & Sons, Ltd |
| References | Atkinson MA, Gianani R. The pancreas in human type 1 diabetes: providing new answers to age-old questions. Curr Opin Endocrinol Diabetes Obes 2009; 16(4): 279-285. Keenan H, Sun J, Levine J, Doria A, Aiello L, Eisenbarth G, et al. Residual insulin production and pancreatic {beta} cell turnover after 50 years of diabetes: Joslin Medalist study. Diabetes 2010; 59: 2846-2853. Silverstein J, Klingensmith G, Copeland K, Plotnick L, Kaufman F, Laffel L, et al. Care of children and adolescents with type 1 diabetes - a statement of the American Diabetes Association. Diabetes Care 2005; 28(1): 186-212. Orban T, Sosenko JM, Cuthbertson D, Krischer JP, Skyler JS, Jackson R, et al. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009; 32(12): 2269-2274. Diamantopoulos S, Allende G, Ferreira J, Ciancio G, Burke G, Pugliese A. Retrospective assessment of islet cell autoantibodies in pancreas organ donors. Diabetes Care 2008; 31(9): 1741-1742. Yip L, Su L, Sheng D, Chang P, Atkinson M, Czesak M, et al. Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol 2009; 10(9): 1026-1033. Campbell-Thompson M, Dixon LR, Wasserfall C, Monroe M, McGuigan JM, Schatz D, et al. Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area. Diabetologia 2009; 52(2): 262-270. Penaranda C, Tang Q, Ruddle NH, Bluestone JA. Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes 2010; 59(6): 1461-1468. Maniatis AK, Yu L, Miao D, Nelson K, Eisenbarth GS. Rapid assays for detection of anti-islet autoantibodies: implications for organ donor screening. J Autoimmun 2001; 16(1): 71-76. Dabelea D, Bell RA, D'Agostino RB, Imperatore G, Johansen JM, Linder B, et al. Incidence of diabetes in youth in the United States. JAMA 2007; 297(24): 2716-2724. In't Veld P, Lievens D, De Grijse J, Ling Z, Van der Auwera B, Pipeleers-Marichal M, et al. Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 2007; 56(9): 2400-2404. Gianani R, Campbell-Thompson M, Sarkar SA, Wasserfall C, Pugliese A, Solis JM, et al. Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia 2010; 53(4): 690-698. Green-Mitchell SM, Cazares LH, Semmes OJ, Nadler JL, Nyalwidhe JO. On-tissue identification of insulin: in situ reduction coupled with mass spectrometry imaging. Proteomics Clin Appl 2011; 5(7-8): 448-453. Bonifacio E, Yu L, Williams A, Eisenbarth G, Bingley P, Marcovina S, et al. Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for National Institute of Diabetes and Digestive and Kidney Diseases consortia. J Clin Endocrinol Metab 2010; 95(7): 3360-3367. von Herrath M. Diabetes: a virus-gene collaboration. Nature 2009; 459(7246): 518-519. Fernandez NA, Liang T, Gaisano HY. Live pancreatic acinar imaging of exocytosis using syncollin-pHluorin. Am J Physiol Cell Physiol 2011; 300(6): C1513-C1523. Vehik K, Beam CA, Mahon JL, Schatz DA, Haller MJ, Sosenko JM, et al. Development of autoantibodies in the TrialNet natural history study. Diabetes Care 2011; 34(9): 1897-1901. Tauriainen S, Salmela K, Rantala I, Knip M, Hyöty H. Collecting high-quality pancreatic tissue for experimental study from organ donors with signs of β-cell autoimmunity. Diabetes Metab Res Rev 2010; 26(7): 585-592. van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 2011; 91(1): 79-118. Mallone R, Mannering SI, Brooks-Worrell BM, Durinovic-Belló I, Cilio CM, Wong FS, et al. Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society. Clin Exp Immunol 2011; 163(1): 33-49. Gianani R, Putnam A, Still T, Yu L, Miao D, Gill RG, et al. Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies. J Clin Endocrinol Metab 2006; 91(5): 1855-1861. Winter WE, Schatz DA. Autoimmune markers in diabetes. Clin Chem 2011; 57(2): 168-175. Rowe PA, Campbell-Thompson ML, Schatz DA, Atkinson MA. The pancreas in human type 1 diabetes. Semin Immunopathol 2011; 33(1): 29-43. Noble J, Valdes A, Cook M, Klitz W, Thomson G, Erlich H. The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet 1996; 59(5): 1134-1148. 2006; 91 2010; 53 2011; 300 2009; 52 2010; 26 2010; 59 2009; 32 2009; 10 2011; 91 2007; 297 2011; 33 2011; 57 2001; 16 2011; 34 2008; 31 2009; 459 2011; 163 2005; 28 2007; 56 1996; 59 2011; 5 2009; 16 2010; 95 Noble J (e_1_2_8_16_1) 1996; 59 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_24_1 e_1_2_8_14_1 e_1_2_8_25_1 e_1_2_8_15_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_10_1 e_1_2_8_21_1 e_1_2_8_11_1 e_1_2_8_22_1 e_1_2_8_12_1 e_1_2_8_23_1 |
| References_xml | – reference: Campbell-Thompson M, Dixon LR, Wasserfall C, Monroe M, McGuigan JM, Schatz D, et al. Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area. Diabetologia 2009; 52(2): 262-270. – reference: Bonifacio E, Yu L, Williams A, Eisenbarth G, Bingley P, Marcovina S, et al. Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for National Institute of Diabetes and Digestive and Kidney Diseases consortia. J Clin Endocrinol Metab 2010; 95(7): 3360-3367. – reference: Diamantopoulos S, Allende G, Ferreira J, Ciancio G, Burke G, Pugliese A. Retrospective assessment of islet cell autoantibodies in pancreas organ donors. Diabetes Care 2008; 31(9): 1741-1742. – reference: Silverstein J, Klingensmith G, Copeland K, Plotnick L, Kaufman F, Laffel L, et al. Care of children and adolescents with type 1 diabetes - a statement of the American Diabetes Association. Diabetes Care 2005; 28(1): 186-212. – reference: Penaranda C, Tang Q, Ruddle NH, Bluestone JA. Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes 2010; 59(6): 1461-1468. – reference: Gianani R, Campbell-Thompson M, Sarkar SA, Wasserfall C, Pugliese A, Solis JM, et al. Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia 2010; 53(4): 690-698. – reference: van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 2011; 91(1): 79-118. – reference: Tauriainen S, Salmela K, Rantala I, Knip M, Hyöty H. Collecting high-quality pancreatic tissue for experimental study from organ donors with signs of β-cell autoimmunity. Diabetes Metab Res Rev 2010; 26(7): 585-592. – reference: Vehik K, Beam CA, Mahon JL, Schatz DA, Haller MJ, Sosenko JM, et al. Development of autoantibodies in the TrialNet natural history study. Diabetes Care 2011; 34(9): 1897-1901. – reference: Green-Mitchell SM, Cazares LH, Semmes OJ, Nadler JL, Nyalwidhe JO. On-tissue identification of insulin: in situ reduction coupled with mass spectrometry imaging. Proteomics Clin Appl 2011; 5(7-8): 448-453. – reference: Fernandez NA, Liang T, Gaisano HY. Live pancreatic acinar imaging of exocytosis using syncollin-pHluorin. Am J Physiol Cell Physiol 2011; 300(6): C1513-C1523. – reference: Gianani R, Putnam A, Still T, Yu L, Miao D, Gill RG, et al. Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies. J Clin Endocrinol Metab 2006; 91(5): 1855-1861. – reference: Orban T, Sosenko JM, Cuthbertson D, Krischer JP, Skyler JS, Jackson R, et al. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009; 32(12): 2269-2274. – reference: Rowe PA, Campbell-Thompson ML, Schatz DA, Atkinson MA. The pancreas in human type 1 diabetes. Semin Immunopathol 2011; 33(1): 29-43. – reference: Atkinson MA, Gianani R. The pancreas in human type 1 diabetes: providing new answers to age-old questions. Curr Opin Endocrinol Diabetes Obes 2009; 16(4): 279-285. – reference: Maniatis AK, Yu L, Miao D, Nelson K, Eisenbarth GS. Rapid assays for detection of anti-islet autoantibodies: implications for organ donor screening. J Autoimmun 2001; 16(1): 71-76. – reference: Winter WE, Schatz DA. Autoimmune markers in diabetes. Clin Chem 2011; 57(2): 168-175. – reference: Keenan H, Sun J, Levine J, Doria A, Aiello L, Eisenbarth G, et al. Residual insulin production and pancreatic {beta} cell turnover after 50 years of diabetes: Joslin Medalist study. Diabetes 2010; 59: 2846-2853. – reference: Yip L, Su L, Sheng D, Chang P, Atkinson M, Czesak M, et al. Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol 2009; 10(9): 1026-1033. – reference: Noble J, Valdes A, Cook M, Klitz W, Thomson G, Erlich H. The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet 1996; 59(5): 1134-1148. – reference: von Herrath M. Diabetes: a virus-gene collaboration. Nature 2009; 459(7246): 518-519. – reference: Mallone R, Mannering SI, Brooks-Worrell BM, Durinovic-Belló I, Cilio CM, Wong FS, et al. Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society. Clin Exp Immunol 2011; 163(1): 33-49. – reference: Dabelea D, Bell RA, D'Agostino RB, Imperatore G, Johansen JM, Linder B, et al. Incidence of diabetes in youth in the United States. JAMA 2007; 297(24): 2716-2724. – reference: In't Veld P, Lievens D, De Grijse J, Ling Z, Van der Auwera B, Pipeleers-Marichal M, et al. Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 2007; 56(9): 2400-2404. – volume: 31 start-page: 1741 issue: 9 year: 2008 end-page: 1742 article-title: Retrospective assessment of islet cell autoantibodies in pancreas organ donors publication-title: Diabetes Care – volume: 34 start-page: 1897 issue: 9 year: 2011 end-page: 1901 article-title: Development of autoantibodies in the TrialNet natural history study publication-title: Diabetes Care – volume: 32 start-page: 2269 issue: 12 year: 2009 end-page: 2274 article-title: Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial‐Type 1 publication-title: Diabetes Care – volume: 53 start-page: 690 issue: 4 year: 2010 end-page: 698 article-title: Dimorphic histopathology of long‐standing childhood‐onset diabetes publication-title: Diabetologia – volume: 91 start-page: 79 issue: 1 year: 2011 end-page: 118 article-title: Type 1 diabetes: etiology, immunology, and therapeutic strategies publication-title: Physiol Rev – volume: 95 start-page: 3360 issue: 7 year: 2010 end-page: 3367 article-title: Harmonization of glutamic acid decarboxylase and islet antigen‐2 autoantibody assays for National Institute of Diabetes and Digestive and Kidney Diseases consortia publication-title: J Clin Endocrinol Metab – volume: 56 start-page: 2400 issue: 9 year: 2007 end-page: 2404 article-title: Screening for insulitis in adult autoantibody‐positive organ donors publication-title: Diabetes – volume: 16 start-page: 279 issue: 4 year: 2009 end-page: 285 article-title: The pancreas in human type 1 diabetes: providing new answers to age‐old questions publication-title: Curr Opin Endocrinol Diabetes Obes – volume: 163 start-page: 33 issue: 1 year: 2011 end-page: 49 article-title: Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen‐reactive T cell responses: position statement of the T‐Cell Workshop Committee of the Immunology of Diabetes Society publication-title: Clin Exp Immunol – volume: 28 start-page: 186 issue: 1 year: 2005 end-page: 212 article-title: Care of children and adolescents with type 1 diabetes – a statement of the American Diabetes Association publication-title: Diabetes Care – volume: 59 start-page: 2846 year: 2010 end-page: 2853 article-title: Residual insulin production and pancreatic {beta} cell turnover after 50 years of diabetes: Joslin Medalist study publication-title: Diabetes – volume: 10 start-page: 1026 issue: 9 year: 2009 end-page: 1033 article-title: Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes publication-title: Nat Immunol – volume: 57 start-page: 168 issue: 2 year: 2011 end-page: 175 article-title: Autoimmune markers in diabetes publication-title: Clin Chem – volume: 16 start-page: 71 issue: 1 year: 2001 end-page: 76 article-title: Rapid assays for detection of anti‐islet autoantibodies: implications for organ donor screening publication-title: J Autoimmun – volume: 33 start-page: 29 issue: 1 year: 2011 end-page: 43 article-title: The pancreas in human type 1 diabetes publication-title: Semin Immunopathol – volume: 26 start-page: 585 issue: 7 year: 2010 end-page: 592 article-title: Collecting high‐quality pancreatic tissue for experimental study from organ donors with signs of ‐cell autoimmunity publication-title: Diabetes Metab Res Rev – volume: 59 start-page: 1134 issue: 5 year: 1996 end-page: 1148 article-title: The role of HLA class II genes in insulin‐dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families publication-title: Am J Hum Genet – volume: 52 start-page: 262 issue: 2 year: 2009 end-page: 270 article-title: Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area publication-title: Diabetologia – volume: 91 start-page: 1855 issue: 5 year: 2006 end-page: 1861 article-title: Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies publication-title: J Clin Endocrinol Metab – volume: 5 start-page: 448 issue: 7‐8 year: 2011 end-page: 453 article-title: On‐tissue identification of insulin: in situ reduction coupled with mass spectrometry imaging publication-title: Proteomics Clin Appl – volume: 459 start-page: 518 issue: 7246 year: 2009 end-page: 519 article-title: Diabetes: a virus–gene collaboration publication-title: Nature – volume: 300 start-page: C1513 issue: 6 year: 2011 end-page: C1523 article-title: Live pancreatic acinar imaging of exocytosis using syncollin‐pHluorin publication-title: Am J Physiol Cell Physiol – volume: 297 start-page: 2716 issue: 24 year: 2007 end-page: 2724 article-title: Incidence of diabetes in youth in the United States publication-title: JAMA – volume: 59 start-page: 1461 issue: 6 year: 2010 end-page: 1468 article-title: Prevention of diabetes by FTY720‐mediated stabilization of peri‐islet tertiary lymphoid organs publication-title: Diabetes – ident: e_1_2_8_8_1 doi: 10.1210/jc.2010-0293 – ident: e_1_2_8_2_1 doi: 10.1097/MED.0b013e32832e06ba – ident: e_1_2_8_3_1 doi: 10.1001/jama.297.24.2716 – ident: e_1_2_8_13_1 doi: 10.1210/jc.2005-1171 – ident: e_1_2_8_21_1 doi: 10.1002/prca.201000152 – ident: e_1_2_8_20_1 doi: 10.1007/s00281-010-0208-x – ident: e_1_2_8_9_1 doi: 10.1006/jaut.2000.0457 – ident: e_1_2_8_17_1 doi: 10.2337/diacare.28.1.186 – ident: e_1_2_8_12_1 doi: 10.2337/dc08-0652 – ident: e_1_2_8_14_1 doi: 10.1111/j.1365-2249.2010.04272.x – ident: e_1_2_8_5_1 doi: 10.1038/459518a – ident: e_1_2_8_15_1 doi: 10.1007/s00125-008-1200-z – ident: e_1_2_8_23_1 doi: 10.1152/ajpcell.00433.2010 – ident: e_1_2_8_25_1 doi: 10.2337/dc11-0560 – ident: e_1_2_8_10_1 doi: 10.1002/dmrr.1129 – ident: e_1_2_8_11_1 doi: 10.2337/db07-0416 – ident: e_1_2_8_4_1 doi: 10.1152/physrev.00003.2010 – ident: e_1_2_8_7_1 doi: 10.1373/clinchem.2010.148205 – ident: e_1_2_8_22_1 doi: 10.1007/s00125-009-1642-y – volume: 59 start-page: 1134 issue: 5 year: 1996 ident: e_1_2_8_16_1 article-title: The role of HLA class II genes in insulin‐dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families publication-title: Am J Hum Genet – ident: e_1_2_8_19_1 doi: 10.1038/ni.1773 – ident: e_1_2_8_18_1 doi: 10.2337/db10-0676 – ident: e_1_2_8_24_1 doi: 10.2337/db09-1129 – ident: e_1_2_8_6_1 doi: 10.2337/dc09-0934 |
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The Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric... The Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric organ... |
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| SubjectTerms | autoantibodies Biomedical Research Cadaver Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - physiopathology Florida HLA Humans Insulin-Secreting Cells - immunology Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Pancreas - immunology Pancreas - pathology Pancreas - physiopathology Tissue Banks - organization & administration type 1 diabetes β-cell |
| Title | Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes |
| URI | https://api.istex.fr/ark:/67375/WNG-CX938TGD-6/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fdmrr.2316 https://www.ncbi.nlm.nih.gov/pubmed/22585677 https://www.proquest.com/docview/1082238062 https://pubmed.ncbi.nlm.nih.gov/PMC3456997 |
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