NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
Strategies such as genomics, proteomics and metabonomics are being applied with increasing frequency in the pharmaceutical industry. For each of these approaches, toxicological response can be measured by terms of deviation from control or baseline status. However, in order to accurately define drug...
Saved in:
Published in | NMR in biomedicine Vol. 18; no. 3; pp. 143 - 162 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.05.2005
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Strategies such as genomics, proteomics and metabonomics are being applied with increasing frequency in the pharmaceutical industry. For each of these approaches, toxicological response can be measured by terms of deviation from control or baseline status. However, in order to accurately define drug‐induced response, it is necessary to characterize the normal degree of physiological variation in the absence of stimuli. Here, 1H NMR spectroscopic‐based analyses of the metabolic composition of urine in experimental animals under various normal physiological conditions are reviewed. In particular, the effects of inter‐animal and diurnal variation, gender, age, diet, species, strain, hormonal status and stress on the biochemical composition of urine are explored. Pattern recognition methods facilitate the comparison of urine NMR spectra over a given time‐course, enabling the establishment of changes in profile and highlighting the dynamic metabolic status of an organism. Thus metabonomic approaches based on information‐rich spectroscopic data sets can be used to evaluate normal physiological variation and for investigation of drug safety issues. Copyright © 2004 John Wiley & Sons, Ltd. |
---|---|
AbstractList | Strategies such as genomics, proteomics and metabonomics are being applied with increasing frequency in the pharmaceutical industry. For each of these approaches, toxicological response can be measured by terms of deviation from control or baseline status. However, in order to accurately define drug-induced response, it is necessary to characterize the normal degree of physiological variation in the absence of stimuli. Here, 1H NMR spectroscopic-based analyses of the metabolic composition of urine in experimental animals under various normal physiological conditions are reviewed. In particular, the effects of inter-animal and diurnal variation, gender, age, diet, species, strain, hormonal status and stress on the biochemical composition of urine are explored. Pattern recognition methods facilitate the comparison of urine NMR spectra over a given time-course, enabling the establishment of changes in profile and highlighting the dynamic metabolic status of an organism. Thus metabonomic approaches based on information-rich spectroscopic data sets can be used to evaluate normal physiological variation and for investigation of drug safety issues. Strategies such as genomics, proteomics and metabonomics are being applied with increasing frequency in the pharmaceutical industry. For each of these approaches, toxicological response can be measured by terms of deviation from control or baseline status. However, in order to accurately define drug‐induced response, it is necessary to characterize the normal degree of physiological variation in the absence of stimuli. Here, 1H NMR spectroscopic‐based analyses of the metabolic composition of urine in experimental animals under various normal physiological conditions are reviewed. In particular, the effects of inter‐animal and diurnal variation, gender, age, diet, species, strain, hormonal status and stress on the biochemical composition of urine are explored. Pattern recognition methods facilitate the comparison of urine NMR spectra over a given time‐course, enabling the establishment of changes in profile and highlighting the dynamic metabolic status of an organism. Thus metabonomic approaches based on information‐rich spectroscopic data sets can be used to evaluate normal physiological variation and for investigation of drug safety issues. Copyright © 2004 John Wiley & Sons, Ltd. Strategies such as genomics, proteomics and metabonomics are being applied with increasing frequency in the pharmaceutical industry. For each of these approaches, toxicological response can be measured by terms of deviation from control or baseline status. However, in order to accurately define drug-induced response, it is necessary to characterize the normal degree of physiological variation in the absence of stimuli. Here, super(1)H NMR spectroscopic-based analyses of the metabolic composition of urine in experimental animals under various normal physiological conditions are reviewed. In particular, the effects of inter-animal and diurnal variation, gender, age, diet, species, strain, hormonal status and stress on the biochemical composition of urine are explored. Pattern recognition methods facilitate the comparison of urine NMR spectra over a given time-course, enabling the establishment of changes in profile and highlighting the dynamic metabolic status of an organism. Thus metabonomic approaches based on information-rich spectroscopic data sets can be used to evaluate normal physiological variation and for investigation of drug safety issues. |
Author | Stanley, Elizabeth G. Lindon, John C. Holmes, Elaine Bollard, Mary E. Nicholson, Jeremy K. |
Author_xml | – sequence: 1 givenname: Mary E. surname: Bollard fullname: Bollard, Mary E. email: mary.bollard@imperial.ac.uk organization: Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW7 2AZ, UK – sequence: 2 givenname: Elizabeth G. surname: Stanley fullname: Stanley, Elizabeth G. organization: Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW7 2AZ, UK – sequence: 3 givenname: John C. surname: Lindon fullname: Lindon, John C. organization: Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW7 2AZ, UK – sequence: 4 givenname: Jeremy K. surname: Nicholson fullname: Nicholson, Jeremy K. organization: Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW7 2AZ, UK – sequence: 5 givenname: Elaine surname: Holmes fullname: Holmes, Elaine organization: Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW7 2AZ, UK |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15627238$$D View this record in MEDLINE/PubMed |
BookMark | eNpF0E1v1DAQBmALtaLbgvgHKCcuKK0d23F8pCvoIrVbqeLjaMbOpDUkdhontPvvMdpCT6NX82g0eo_JQYgBCXnD6CmjtDoLdjjVXL4gK0a1LpnQ1QFZUS2rkouGHpHjlH5SShvBq5fkiMm6UhVvVuTH9uqmtJCwLQacwcYQB-8KGMcpgrvDVHRxKvA39AvMPtwW490u-djHW--gL3zo-gWDyy6GwvqYo28LF4cxJj_7GF6Rww76hK-f5gn5-unjl_WmvLy--Lz-cFk6wRpZIgUNrUQrK4laO8tb22kACUoopThyEKxTFrnMUSN1gnbgJFN1xzqn-Ql5t7-bH79fMM1m8Mlh30PAuCTDtOB1I2iGb5_gYgdszTj5Aaad-ddJBu_34MH3uHveU_O3apOrNrlqsz2_yiPrcq99mvHxv4bpl6kVV9J8316Y-vzbjdis12bD_wC-_4Mw |
CitedBy_id | crossref_primary_10_1016_S1872_2040_09_60052_9 crossref_primary_10_1186_1471_2105_9_105 crossref_primary_10_1164_rccm_200711_1716OC crossref_primary_10_3390_molecules23030554 crossref_primary_10_1016_j_ddtec_2007_10_012 crossref_primary_10_3390_nu13051567 crossref_primary_10_1016_j_radonc_2015_07_037 crossref_primary_10_1039_c3mb70215d crossref_primary_10_1007_s11306_014_0629_y crossref_primary_10_1021_pr0704332 crossref_primary_10_1155_2016_9162074 crossref_primary_10_1021_ac500188j crossref_primary_10_1021_pr200489n crossref_primary_10_1616_1476_2137_14578 crossref_primary_10_1016_j_tox_2012_10_015 crossref_primary_10_1016_j_ab_2006_02_033 crossref_primary_10_1021_pr900012d crossref_primary_10_1139_apnm_2014_0060 crossref_primary_10_1093_ajcn_84_3_531 crossref_primary_10_3390_toxics11080688 crossref_primary_10_1016_j_drudis_2008_05_008 crossref_primary_10_1164_rccm_201103_0474CI crossref_primary_10_1016_j_mce_2014_06_016 crossref_primary_10_1517_17425255_2_5_687 crossref_primary_10_1007_s11306_007_0099_6 crossref_primary_10_3736_jcim20070424 crossref_primary_10_1021_acs_analchem_0c01682 crossref_primary_10_1007_s11306_024_02121_2 crossref_primary_10_1016_j_taap_2010_07_020 crossref_primary_10_3390_metabo12080744 crossref_primary_10_1002_nbm_1176 crossref_primary_10_1016_j_pharmthera_2005_06_008 crossref_primary_10_1002_jssc_200900171 crossref_primary_10_1021_jf061016x crossref_primary_10_1080_15376510701623193 crossref_primary_10_1093_ajcn_82_3_497 crossref_primary_10_1021_pr800999t crossref_primary_10_1002_ange_200903363 crossref_primary_10_1016_j_abb_2015_07_016 crossref_primary_10_1038_srep18852 crossref_primary_10_1089_omi_2007_0023 crossref_primary_10_1017_S0031182010000697 crossref_primary_10_1111_evj_12333 crossref_primary_10_1093_bioinformatics_btr522 crossref_primary_10_1007_s11306_007_0091_1 crossref_primary_10_1093_toxsci_kfm077 crossref_primary_10_3109_1354750X_2014_983167 crossref_primary_10_1039_C5MB00158G crossref_primary_10_2131_jts_32_205 crossref_primary_10_3390_metabo12030214 crossref_primary_10_1016_j_bbr_2012_02_026 crossref_primary_10_1016_j_theriogenology_2015_02_004 crossref_primary_10_1021_pr500434s crossref_primary_10_1007_s11306_018_1321_4 crossref_primary_10_1007_s12562_018_1266_6 crossref_primary_10_1021_acs_jproteome_5b00354 crossref_primary_10_1093_annonc_mdm533 crossref_primary_10_1016_j_biocel_2010_05_001 crossref_primary_10_1016_j_jchromb_2008_06_004 crossref_primary_10_1007_s11306_006_0047_x crossref_primary_10_1590_S0103_40142010000300006 crossref_primary_10_3945_ajcn_2010_29672 crossref_primary_10_1016_j_talanta_2013_07_070 crossref_primary_10_1002_rcm_2583 crossref_primary_10_1248_bpb_30_667 crossref_primary_10_1021_acs_jproteome_5b00919 crossref_primary_10_1073_pnas_0705685105 crossref_primary_10_1016_j_pnmrs_2017_01_001 crossref_primary_10_1021_pr060623x crossref_primary_10_1007_s11306_010_0271_2 crossref_primary_10_1016_j_chemolab_2008_01_003 crossref_primary_10_1016_j_nurx_2006_05_003 crossref_primary_10_1007_s10858_011_9492_6 crossref_primary_10_1016_j_molonc_2014_07_012 crossref_primary_10_1016_j_chemolab_2012_07_011 crossref_primary_10_1002_jssc_200900152 crossref_primary_10_1021_ac9004875 crossref_primary_10_1146_annurev_anchem_1_031207_113026 crossref_primary_10_1007_s11306_015_0789_4 crossref_primary_10_1007_s11306_010_0234_7 crossref_primary_10_1016_j_aca_2010_10_035 crossref_primary_10_1089_omi_2015_0119 crossref_primary_10_1016_j_jpba_2013_07_020 crossref_primary_10_1111_j_1469_185X_2010_00157_x crossref_primary_10_1186_1752_0509_6_S1_S15 crossref_primary_10_1186_1471_2334_14_53 crossref_primary_10_1517_17425255_4_6_665 crossref_primary_10_1016_j_jflm_2018_12_005 crossref_primary_10_1002_jbt_20219 crossref_primary_10_1021_pr0605217 crossref_primary_10_1371_journal_pone_0073076 crossref_primary_10_1016_j_ab_2007_08_028 crossref_primary_10_1016_S0254_6272_14_60073_X crossref_primary_10_1016_j_febslet_2012_01_049 crossref_primary_10_1021_acs_jmedchem_5b01335 crossref_primary_10_1021_jm401803b crossref_primary_10_1134_S1607672906050139 crossref_primary_10_1021_ac5025039 crossref_primary_10_1080_00498254_2019_1697015 crossref_primary_10_1016_j_jmr_2009_01_027 crossref_primary_10_1007_s11745_009_3296_4 crossref_primary_10_1007_s00216_013_7254_x crossref_primary_10_1016_j_ab_2015_02_024 crossref_primary_10_3390_molecules20047000 crossref_primary_10_1039_C9AY00594C crossref_primary_10_1002_wsbm_1311 crossref_primary_10_3748_wjg_14_3891 crossref_primary_10_1007_s11306_011_0326_z crossref_primary_10_1007_s12603_015_0560_6 crossref_primary_10_1021_ac071278d crossref_primary_10_1016_j_clinbiochem_2012_11_012 crossref_primary_10_1002_biof_5520340207 crossref_primary_10_1016_j_tjnut_2023_06_039 crossref_primary_10_1021_jf0527798 crossref_primary_10_1016_j_chemolab_2006_06_012 crossref_primary_10_1007_s12609_012_0090_8 crossref_primary_10_1007_s00216_006_0546_7 crossref_primary_10_1021_acs_jproteome_5b00885 crossref_primary_10_1016_j_anl_2016_10_003 crossref_primary_10_1021_pr100815q crossref_primary_10_2116_analsci_21_1259 crossref_primary_10_1200_JCO_2006_09_7550 crossref_primary_10_1080_00032719_2015_1041028 crossref_primary_10_1007_s11095_006_0025_z crossref_primary_10_1021_tx700151t crossref_primary_10_1016_j_neurobiolaging_2016_11_007 crossref_primary_10_1097_CCM_0b013e31822571ce crossref_primary_10_3390_molecules26071841 crossref_primary_10_1016_j_biopha_2012_10_013 crossref_primary_10_1021_pr060412s crossref_primary_10_1016_j_neuroscience_2012_05_019 crossref_primary_10_1007_s11306_008_0106_6 crossref_primary_10_1016_j_nut_2020_110867 crossref_primary_10_1021_ac801053g crossref_primary_10_1016_j_abb_2017_02_009 crossref_primary_10_1016_j_ijpara_2009_11_003 crossref_primary_10_1016_j_aquatox_2009_09_006 crossref_primary_10_1186_1471_2105_10_363 crossref_primary_10_1371_journal_pone_0067654 crossref_primary_10_1002_mrc_2485 crossref_primary_10_1007_s00216_012_6339_2 crossref_primary_10_1016_j_taap_2014_01_007 crossref_primary_10_1021_pr050404w crossref_primary_10_3390_cells13060475 crossref_primary_10_1007_s11306_017_1269_9 crossref_primary_10_1038_s41598_020_75135_0 crossref_primary_10_1002_rcm_3078 crossref_primary_10_1038_s42003_020_01262_z crossref_primary_10_3390_metabo2030496 crossref_primary_10_1016_j_chemolab_2005_10_002 crossref_primary_10_1039_c3mb70386j crossref_primary_10_1021_ac102097u crossref_primary_10_1016_j_mee_2019_02_005 crossref_primary_10_1021_pr060522z crossref_primary_10_14348_molcells_2015_0126 crossref_primary_10_1007_s11306_012_0420_x crossref_primary_10_23736_S0026_4806_22_07957_5 crossref_primary_10_1021_acs_jproteome_5b00782 crossref_primary_10_1002_jps_21281 crossref_primary_10_1007_s11306_017_1162_6 crossref_primary_10_1021_pr060535c crossref_primary_10_1136_bmjpo_2017_000192 crossref_primary_10_1371_journal_pone_0063044 crossref_primary_10_1016_j_jmr_2008_09_022 crossref_primary_10_1038_msb_2008_56 crossref_primary_10_1586_14737159_7_3_247 crossref_primary_10_30539_ijvm_v45i2_1258 crossref_primary_10_1002_mrc_4558 crossref_primary_10_1016_j_jpba_2015_02_006 crossref_primary_10_1177_1933719109340928 crossref_primary_10_1111_j_1742_4658_2007_05673_x crossref_primary_10_1016_j_chemolab_2010_07_006 crossref_primary_10_1088_0957_4484_21_12_125105 crossref_primary_10_1155_2011_509043 crossref_primary_10_1021_pr050255h crossref_primary_10_1016_j_taap_2012_05_002 crossref_primary_10_1007_s11306_014_0647_9 crossref_primary_10_1007_s11101_006_9031_3 crossref_primary_10_1007_s00216_018_0961_6 crossref_primary_10_1016_j_jchromb_2016_06_047 crossref_primary_10_1530_JOE_12_0119 crossref_primary_10_3390_metabo10110449 crossref_primary_10_4155_bio_09_143 crossref_primary_10_1007_s11306_012_0489_2 crossref_primary_10_1016_j_yexcr_2014_04_019 crossref_primary_10_1021_ac060979s crossref_primary_10_1371_journal_pone_0076813 crossref_primary_10_1586_14737159_8_5_617 crossref_primary_10_1007_s11306_011_0389_x crossref_primary_10_2217_14622416_7_7_1087 crossref_primary_10_1007_s10858_011_9485_5 crossref_primary_10_1155_2013_303982 crossref_primary_10_1002_bmc_1185 crossref_primary_10_1016_j_ijid_2016_02_012 crossref_primary_10_1080_10408347_2020_1843130 crossref_primary_10_1007_s00436_011_2439_8 crossref_primary_10_1016_j_pnmrs_2007_02_002 crossref_primary_10_2174_0929867324666171006151408 crossref_primary_10_2217_14796708_1_5_659 crossref_primary_10_1007_s10334_006_0054_y crossref_primary_10_1093_ajcn_86_5_1687 crossref_primary_10_1164_rccm_200606_769OC crossref_primary_10_1371_journal_pntd_0000807 crossref_primary_10_1007_s11306_016_1122_6 crossref_primary_10_1016_j_exger_2013_10_010 crossref_primary_10_3748_wjg_v12_i30_4773 crossref_primary_10_1007_s11306_013_0524_y crossref_primary_10_1007_s11306_011_0289_0 crossref_primary_10_1039_b604498k crossref_primary_10_1080_10641950701436073 crossref_primary_10_1080_19440040903314015 crossref_primary_10_1007_s12010_011_9240_0 crossref_primary_10_1016_j_pnmrs_2017_11_003 crossref_primary_10_1016_j_jpba_2009_12_026 crossref_primary_10_1016_j_jpba_2010_07_021 crossref_primary_10_1007_s12263_009_0120_y crossref_primary_10_1038_nprot_2007_376 crossref_primary_10_1021_ac062305n crossref_primary_10_1039_C5RA10130A crossref_primary_10_1007_s11306_010_0226_7 crossref_primary_10_1016_j_mce_2016_01_003 crossref_primary_10_1002_ijc_31323 crossref_primary_10_1021_pr070340k crossref_primary_10_1073_pnas_0810190106 crossref_primary_10_3724_SP_J_1008_2009_00565 crossref_primary_10_1002_nbm_1323 crossref_primary_10_1007_s11306_010_0252_5 crossref_primary_10_1177_1091581812441030 crossref_primary_10_1093_ndt_gfq554 crossref_primary_10_1155_2017_4039425 crossref_primary_10_2131_jts_34_343 crossref_primary_10_5702_massspec_55_227 crossref_primary_10_1007_s12263_008_0084_3 crossref_primary_10_1016_j_jchromb_2008_04_034 crossref_primary_10_1016_j_foodres_2012_11_014 crossref_primary_10_1002_elps_201200007 crossref_primary_10_1039_C8RA00819A crossref_primary_10_1007_s11306_006_0042_2 crossref_primary_10_1021_ac901240j crossref_primary_10_1016_j_exger_2011_02_012 crossref_primary_10_1097_CCM_0b013e31822818ca crossref_primary_10_1038_s41597_020_0545_0 crossref_primary_10_1038_s41598_018_26804_8 crossref_primary_10_1039_C4AN00552J crossref_primary_10_1152_ajplung_00231_2010 crossref_primary_10_1039_C5MB00030K crossref_primary_10_1007_s11356_018_3518_5 crossref_primary_10_1021_ac102338n crossref_primary_10_1039_C5AY01079A crossref_primary_10_1039_C7FO00081B crossref_primary_10_1093_annonc_mdq606 crossref_primary_10_4155_fmc_09_54 crossref_primary_10_1021_pr900576y crossref_primary_10_3389_fonc_2018_00494 crossref_primary_10_1080_15376510701611032 crossref_primary_10_1186_1471_2105_8_S7_S3 crossref_primary_10_1016_j_ab_2006_04_014 crossref_primary_10_2217_bmm_09_11 crossref_primary_10_1021_pr200960u crossref_primary_10_1590_s1980_6574201700020010 crossref_primary_10_1038_hr_2011_182 crossref_primary_10_1021_ac900545q crossref_primary_10_1371_journal_pntd_0006044 crossref_primary_10_1002_mrd_22450 crossref_primary_10_1016_j_chom_2010_01_008 crossref_primary_10_1371_journal_pone_0028824 crossref_primary_10_1021_ac051632c crossref_primary_10_1177_117727190700200040 crossref_primary_10_1016_j_ntt_2018_07_002 crossref_primary_10_1080_07315724_2009_10719787 crossref_primary_10_1016_j_chemolab_2006_08_014 crossref_primary_10_1155_2011_403260 crossref_primary_10_1016_j_talanta_2013_03_039 crossref_primary_10_1007_s11306_011_0306_3 crossref_primary_10_1016_j_taap_2009_11_019 crossref_primary_10_1021_pr100331j crossref_primary_10_1002_anie_200903363 crossref_primary_10_1016_j_aca_2008_11_034 crossref_primary_10_1016_j_jbiosc_2010_04_010 crossref_primary_10_1039_C7RA02056B crossref_primary_10_2174_0929867328666210810122350 crossref_primary_10_1039_c4ay00374h crossref_primary_10_1016_j_chemolab_2008_06_012 crossref_primary_10_1016_j_talanta_2011_04_060 crossref_primary_10_1007_s00216_011_5310_y crossref_primary_10_1089_omi_2009_0012 crossref_primary_10_1002_nbm_1370 crossref_primary_10_1093_bib_bbac373 crossref_primary_10_1002_nbm_1373 crossref_primary_10_1016_j_trac_2007_08_009 crossref_primary_10_1016_j_chemosphere_2009_04_025 crossref_primary_10_1016_j_cca_2019_05_012 crossref_primary_10_1002_nbm_1258 crossref_primary_10_1021_acs_jproteome_5b00131 crossref_primary_10_1007_s11306_012_0472_y crossref_primary_10_1002_jssc_201100532 crossref_primary_10_1038_s41598_023_47615_6 crossref_primary_10_1016_j_pnmrs_2007_03_002 crossref_primary_10_1002_nbm_1816 crossref_primary_10_1093_toxsci_kfq358 crossref_primary_10_1007_s11434_007_0389_4 crossref_primary_10_1016_S1872_2040_08_60081_X crossref_primary_10_1021_acs_jproteome_5b00719 crossref_primary_10_1186_1471_230X_14_115 crossref_primary_10_1039_C4MB00463A crossref_primary_10_1002_nbm_1242 crossref_primary_10_1016_j_bbrep_2017_05_004 crossref_primary_10_1002_nbm_1123 crossref_primary_10_4103_UROS_UROS_2_19 crossref_primary_10_1021_ac051972y crossref_primary_10_1002_eng2_12383 crossref_primary_10_1016_j_chemolab_2011_06_002 crossref_primary_10_1038_msb_2011_57 crossref_primary_10_1111_jfs_12473 crossref_primary_10_2174_0929867324666171003121127 crossref_primary_10_1080_10408347_2015_1106932 crossref_primary_10_1007_s11306_012_0484_7 crossref_primary_10_1111_j_1365_2893_2009_01252_x crossref_primary_10_1039_c1mb05023k crossref_primary_10_1124_pr_110_003525 crossref_primary_10_1371_journal_pone_0097773 crossref_primary_10_1155_2014_731620 crossref_primary_10_3164_jcbn_12_118 crossref_primary_10_1007_s11306_005_4435_4 crossref_primary_10_1039_B906712B crossref_primary_10_1111_j_1467_3010_2008_00732_x crossref_primary_10_1021_ac300096j crossref_primary_10_1039_c005291d crossref_primary_10_1007_s10334_006_0058_7 crossref_primary_10_1080_10408444_2017_1309638 crossref_primary_10_1007_s11306_010_0232_9 crossref_primary_10_1021_ac201065j crossref_primary_10_1186_1556_276X_8_236 crossref_primary_10_1021_ac070212f crossref_primary_10_1016_j_chroma_2007_10_065 crossref_primary_10_1039_b818802e crossref_primary_10_1007_s11306_018_1403_3 crossref_primary_10_1021_acs_jproteome_1c00851 crossref_primary_10_1016_j_tibtech_2006_02_001 crossref_primary_10_1021_jf104129k crossref_primary_10_1002_mrc_2534 crossref_primary_10_1016_j_canlet_2013_09_011 crossref_primary_10_1002_mrc_2530 crossref_primary_10_1586_14737159_6_4_575 |
ContentType | Journal Article |
Copyright | Copyright © 2004 John Wiley & Sons, Ltd. Copyright 2004 John Wiley & Sons, Ltd. |
Copyright_xml | – notice: Copyright © 2004 John Wiley & Sons, Ltd. – notice: Copyright 2004 John Wiley & Sons, Ltd. |
DBID | BSCLL CGR CUY CVF ECM EIF NPM 7QO 8FD FR3 P64 |
DOI | 10.1002/nbm.935 |
DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts |
DatabaseTitleList | MEDLINE Engineering Research Database |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Physics |
EISSN | 1099-1492 |
EndPage | 162 |
ExternalDocumentID | 15627238 NBM935 ark_67375_WNG_6BVR4HCC_H |
Genre | reviewArticle Journal Article Review |
GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 123 1L6 1OB 1OC 1ZS 31~ 33P 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52V 52W 52X 53G 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAVGM AAXRX AAZKR ABCQN ABCUV ABEML ABHUG ABIJN ABPVW ABQWH ABWRO ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACSCC ACXBN ACXME ACXQS ADAWD ADBBV ADBTR ADDAD ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFVGU AFZJQ AGJLS AHBTC AIACR AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 DUUFO EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE FUBAC G-S G.N GNP GODZA H.X HBH HF~ HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M65 MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- P2P P2W P2X P2Z P4D PALCI Q.N Q11 QB0 QRW R.K RGB RIWAO RJQFR ROL RWI RX1 SAMSI SUPJJ SV3 UB1 V2E W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WRC WUP WVDHM WXSBR XG1 XPP XV2 ZA5 ZZTAW ~IA ~WT AITYG HGLYW OIG CGR CUY CVF ECM EIF NPM 7QO 8FD FR3 P64 |
ID | FETCH-LOGICAL-c4185-e0a9ad5eb525e99cb3dbf9aa5a747773e3a41f7be357779e0c40fac5176f1fc93 |
IEDL.DBID | DR2 |
ISSN | 0952-3480 |
IngestDate | Fri Aug 16 20:27:38 EDT 2024 Sat Sep 28 07:46:13 EDT 2024 Sat Aug 24 01:01:01 EDT 2024 Wed Jan 17 05:09:31 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Language | English |
License | Copyright 2004 John Wiley & Sons, Ltd. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c4185-e0a9ad5eb525e99cb3dbf9aa5a747773e3a41f7be357779e0c40fac5176f1fc93 |
Notes | ark:/67375/WNG-6BVR4HCC-H ArticleID:NBM935 istex:D2598EE759B5B3BCDC0E0DDB3B8E38DD16682A5D ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
PMID | 15627238 |
PQID | 19436840 |
PQPubID | 23462 |
PageCount | 20 |
ParticipantIDs | proquest_miscellaneous_19436840 pubmed_primary_15627238 wiley_primary_10_1002_nbm_935_NBM935 istex_primary_ark_67375_WNG_6BVR4HCC_H |
PublicationCentury | 2000 |
PublicationDate | May 2005 |
PublicationDateYYYYMMDD | 2005-05-01 |
PublicationDate_xml | – month: 05 year: 2005 text: May 2005 |
PublicationDecade | 2000 |
PublicationPlace | Chichester, UK |
PublicationPlace_xml | – name: Chichester, UK – name: England |
PublicationTitle | NMR in biomedicine |
PublicationTitleAlternate | NMR Biomed |
PublicationYear | 2005 |
Publisher | John Wiley & Sons, Ltd |
Publisher_xml | – name: John Wiley & Sons, Ltd |
References | Nicholson JK, Wilson ID. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2003; 8: 668-676. Holmes E, Nicholls AW, Lindon JC, Connor SC, Connelly JC, Haselden JN, Damment SJ, Spraul M, Neidig P, Nicholson JK. Chemometric models for toxicity classification based on NMR spectra of biofluids. Chem. Res. Toxicol. 2000; 13(6): 471-478. Holmes E, Bonner FW, Nicholson JK. Comparative biochemical effects of low doses of mercury II chloride in the F344 rat and the Multimammate mouse (Mastomys natalensis). Comp. Biochem. Physiol. 1996; 114C(1): 7-15. Zuppi C, Messana I, Forni F, Rossi C, Pennacchietti L, Ferrari F, Giardina B. 1H NMR spectra of normal urines: reference ranges of the major metabolites. Clin. Chim. Acta 1997; 265(1): 85-97. Raamsdonk LM, Teusink B, Broadhurst D, Zhang N, Hayes A, Walsh MC, Berden JA, Brindle KM, Kell DB, Rowland JJ, Westerhoff HV, van Dam K, Oliver SG. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotechnol. 2001; 19(1): 45-50. Nicholls AW, Nicholson JK, Haselden JN, Waterfield CJ. A metabonomic approach to the investigation of drug-induced phospholipidosis: a NMR spectroscopy and pattern recognition study. Biomarkers 2000; 5: 410-423. Kattermann R, Sirowej H. Liver injury and lipid metabolism: sex differences in the fatty liver induced by d-galactosamine. Acta Hepatogastroenterol. (Stuttg.) 1979; 26: 112-121. Elfarra AA, Jakobson I, Anders MW. Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. Biochem. Pharmac. 1986; 35(2): 283-288. Bain MD, Jones M, Borriello SP, Reed PJ, Tracey BM, Chalmers RA, Stacey TE. Contribution of gut bacterial metabolism to human metabolic disease. Lancet 1988; 1(8594): 1078-1079. Gavaghan CL, Wilson ID, Nicholson JK. Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLSDA. FEBS Lett. 2002; 530: 191-196. Timbrell JA, Draper R, Waterfield CJ. Biomarkers in toxicology. Toxicol. Ecotoxicol. News 1994; 1(1): 4-14. Phipps AN, Wright B, Stewart J, Wilson ID. Use of proton NMR for determining changes in metabolite excretion profiles induced by dietary changes in the rat. Pharm. Sci. 1997; 3: 143-146. Jones AR. Some observations on the urinary excretion of glycine conjugates by laboratory animals. Xenobiotica 1982; 12: 387-395. Holmes E, Bonner FW, Nicholson JK. Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis). Arch. Toxicol. 1995; 70(2): 89-95. Bales JR, Higham DP, Howe I, Nicholson JK, Sadler PJ. Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine. Clin. Chem. 1984; 30(3): 426-432. Fujimura A, Ohashi, Ebihara A. Chronopharmacological study of furosemide; (VIII) influence of feeding restriction. Life Sci. 1991; 49(24): 1829-1834. Muraoka Y, Itoh F. Sex difference of mercuric chloride-induced renal tubular necrosis in rats from the aspect of sex differences in renal mercury concentration and sulfhydryl levels. J. Toxicol. Sci. 1980; 5(3): 203-214. Fiehn O. Metabolomics-the link between genotypes and phenotypes. Plant Mol. Biol. 2002; 48(1-2): 155-171. Holmes E, Nicholls AW, Lindon JC, Ramos S, Spraul M, Neidig P, Connor SC, Connelly J, Damnent SJ, Haselden J, Nicholson JK. Development of a model for classification of toxin-induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition. NMR Biomed. 1998; 11(4-5): 235-244. Gavaghan CL, Holmes E, Lenz E, Wilson ID, Nicholson JK. An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse. FEBS Lett. 2000; 484(3): 169-174. Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999; 11: 1181-1189. Moser VC, Padilla S. Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats. Toxicol. Appl. Pharmac. 1998; 149(1): 107-119. Tobler I, Murison R, Ursin R, Ursin H, Borbely AA. The effect of sleep deprivation and recovery sleep on plasma corticosterone in the rat. Neurosci. Lett. 1983; 35(3): 297-300. Griffin JL, Williams HJ, Sang E, Nicholson JK. Abnormal lipid profile of dystrophic cardiac tissue as demonstrated by one- and two-dimensional magic-angle spinning (1)H NMR spectroscopy. Magn. Reson. Med. 2001; 46(2): 249-255. Ricketts WG, Birchenall-Sparks MC, Hardwick JP, Richardson A. Effect of age and dietary restriction on protein synthesis by isolated kidney cells. J. Cell. Physiol. 1985; 125: 492-498. Lindon JC, Holmes E, Nicholson JK. So what's the deal with metabonomics? Anal. Chem. 2003; 75(17): 384A-391A. Aardema MJ, MacGregor JT. Toxicology and genetic toxicology in the new era of 'toxicogenomics': impact of '-omics' technologies. Mutat. Res. 2002; 499(1): 13-25. Joossen JV. Mechanisms of hypercholesterolemia and atherosclerosis. Acta Cardiol. Suppl. 1988; 29: 63-83. Griffin JL. Metabolic profiles to define the genome: can we hear the silent phenotypes. Phil. Trans. Biol. Sci. R. Soc. Lond. B 2004; 2: 1471-2970 on-line. Spraul M, Hofmann M, Lindon JC, Farrant RD, Seddon MJ, Nicholson JK, Wilson ID. Evaluation of liquid chromatography coupled with high-field 1H NMR spectroscopy for drug metabolite detection and characterization: the identification of paracetamol metabolites in urine and bile. NMR Biomed. 1994; 7(7): 295-303. Tucker SM, Mason RL, Beauchene RE. Influence of diet and feed restriction on kidney function of ageing male rats. J. Gerontol. 1976; 31: 264-270. Bonate PL. Gender-related differences in xenobiotic metabolism. J. Clin. Pharmac. 1991; 31: 684-690. Holmes E, Nicholson JK, Tranter G. Metabonomic characterisation of genetic variation in toxicological and metabolic responses using probabalistic neural networks. Chem. Res. Toxicol. 2001; 24: 182-191. Eriksson L, Johansson E, Kettaneh-Wold H, Wold S. Introduction to Multi and Megavariate Analysis using Projection Methods (PCA & PLS). Umetrics: Umeå, 1999. Singer S, Sivaraja M, Souza K, Millis K, Corson JM. 1H-NMR detectable fatty acyl chain unsaturation in excised leiomyosarcoma correlate with grade and mitotic activity. J. Clin. Invest. 1996; 98(2): 244-250. Bendall JK, Heymes C, Wright TJ, Wheatcroft S, Grieve DJ, Shah AM, Cave AC. Strain-dependent variation in vascular responses to nitric oxide in the isolated murine heart. J. Mol. Cell Cardiol. 2002; 34(10): 1325-1333. Honglian S, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, Kristal BS. Characterisation of diet-dependent metabolic serotypes: primary validation of male and female serotypes in independent cohorts of rats. J. Nutr. 2002; 132: 1039-1046. Gavaghan CL, Nicholson JK, Connor SC, Wilson ID, Wright B, Holmes E. Directly coupled high-performance liquid chromatography and nuclear magnetic resonance spectroscopic with chemometric studies on metabolic variation in Sprague-Dawley rats. Anal. Biochem. 2001; 291(2): 245-252. Clayton TA, Lindon JC, Everett JR, Charuel C, Hanton G, Le Net JL, Provost JP, Nicholson JK. An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria. Arch. Toxicol. 2003; 77: 208-217. Levin S, Semler D, Ruben Z. Effects of two weeks of feed restriction on some common toxicologic parameters in Sprague Dawley rats. Toxicol. Pathol. 1993; 21: 1-14. Panin LE, Starova TIu, Tret'iakova TA, Kolpakov AR, Kolosova IE, Solov'ev VN. Changes in glycolysis and glycogenolysis in tissues and level of certain hormones in blood and urine from rats with varying lengths of cold adaptation. Vopr. Med. Khim. 1995; 41(4): 14-18. Gartland KP, Eason CT, Bonner FW, Nicholson JK. Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat. Arch. Toxicol. 1990; 64(1): 14-25. Morishima HO, Abe Y, Matsuo M, Akiba K, Masaoka T, Cooper TB. Gender-related differences in cocaine toxicity in the rat. J. Lab. Clin. Med. 1993; 122(2): 157-163. Nicholson JK, Buckingham MJ, Sadler PJ. High resolution 1H NMR studies of vertebrate blood and plasma. Biochem. J. 1983; 211(3): 605-615. Sanins SM, Nicholson JK, Elcombe C, Timbrell J. Hepatotoxin-induced hypertaurinuria: a proton NMR study. Arch. Toxicol. 1990; 64: 407-411. Jellum E, Bjornson I, Nesbakken R, Johansson E, Wold S. Classification of human cancer cells by means of capillary gas chromatography and pattern recognition analysis. J. Chromatogr. 1981; 217: 231-237. Bollard ME, Keun H, Ebbels T, Beckonert O, Antti H, Lindon JC, Holmes E, Nicholson JK. Comparative metabonomics of differential species toxicity of hydrazine in the rat and mouse. Toxicol. Appl. Pharmac. accepted for publication. Ayesh R, Mitchell SC, Smith RL. Dysfunctional N-oxidation of trimethylamine and the influence of testosterone treatment in man. Pharmacogenetics 1995; 5: 244-246. Goodwin BL, Ruthven CRJ, Sandler M. Gut flora and the origin of some urinary aromatic phenolic compounds. Biochem. Pharmac. 1994; 47: 2294-2297. Gartland KP, Bonner FW, Timbrell JA, Nicholson JK. Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F344 rat. Arch. Toxicol. 1989; 63(2): 97-106. Shapiro BH, Agrawal AK, Pampori NA. Gender differences in drug metabolism regulated by growth hormone. Int. J. Biochem. Cell. Biol. 1995; 1: 9-20. Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reily MD, Robertson D, Stevens GJ, Luke P, Breau AP, Cantor GH, Bible RH, Niederhauser U, Senn H, Schlotterbeck G, Sidelmann UG, Laursen SM, Tymiak A, Car BD, Lehman-McKeeman L, Colet JM, Loukaci A, Thomas C. Contemporary issues in toxicology the role of metabonomics in to 2002; 14 1993; 23 1991; 17 1993; 21 2004; 9 2004; 2 1997; 3 2001; 46 1979 1993; 122 1998; 17 1980; 307 1979; 26 1989; 32 2000; 13 2000; 127 1995; 25 1997; 265 1986; 5 1984 2000; 484 1982; 257 1975; 82 1989; 35 1989; 36 1998; 11 1994; 76 1989; 63 1976; 47 2002; 74 2002; 132 2000; 68 2002; 499 1982; 31 2002; 530 2002; 1 1998 1994 1991 1995; 1 2001; 24 1996; 98 1995; 5 1998; 252 2001; 20 1999 2000; 748 1995; 41 1984; 30 1988; 29 1995; 49 2002; 67 1984; 33 2002; 521 1962; 23 2001; 39 1981; 217 1998; 149 2003; 187 2001; 30 1996; 114C 1982; 12 1997; 116 1984; 20 1995; 70 1992; 64–65 2000; 5 1986; 35 1987; 7 1985; 125 2003; 16 1993; 3 1996; 348 1976; 31 2002; 48 1991; 49 2001; 293 2001; 295 1961; 4 2001; 291 1993; 77 1978; 192 2003; 8 2001; 19 1999; 11 1990; 253 1983; 69 1980; 27 1998; 28 1983; 211 1989; 21 2002; 30 2002; 34 1991; 31 2003; 490 1994; 47 2002 1989; 27 2003; 75 1983; 35 1994; 40 2003; 77 1988; 1 1990; 64 2002; 25 1989; 12 1980; 12 1980; 5 1994; 1 1994; 7 |
References_xml | – volume: 23 start-page: 203 year: 1962 end-page: 205 article-title: Citric acid excretion in normal adults and in patients with renal calculus publication-title: Clin. Sci. – volume: 2 start-page: 1471 year: 2004 end-page: 2970 article-title: Metabolic profiles to define the genome: can we hear the silent phenotypes publication-title: Phil. Trans. Biol. Sci. R. Soc. Lond. B – volume: 27 start-page: 331 issue: 5 year: 1989 end-page: 340 article-title: Experimental renal papilliary necrosis in the Syrian hamster publication-title: Food Chem. Toxicol. – volume: 29 start-page: 63 year: 1988 end-page: 83 article-title: Mechanisms of hypercholesterolemia and atherosclerosis publication-title: Acta Cardiol. Suppl. – volume: 265 start-page: 85 issue: 1 year: 1997 end-page: 97 article-title: H NMR spectra of normal urines: reference ranges of the major metabolites publication-title: Clin. Chim. Acta – volume: 34 start-page: 1325 issue: 10 year: 2002 end-page: 1333 article-title: Strain‐dependent variation in vascular responses to nitric oxide in the isolated murine heart publication-title: J. Mol. Cell Cardiol. – volume: 14 start-page: 583 year: 2002 end-page: 610 article-title: Metabonomic Technology as a tool for rapid throughput toxicity screening publication-title: Compreh. Toxicol. – volume: 187 start-page: 137 issue: 3 year: 2003 end-page: 146 article-title: Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project publication-title: Toxicol. Appl. Pharmac. – volume: 32 start-page: 129 issue: 3 year: 1989 end-page: 134 article-title: Effects of drinking water acidification, restriction of water supply and individual cageing on parameters of toxicological studies in rats publication-title: Z. Versuchstierkd. – volume: 23 start-page: 1427 issue: 12 year: 1993 end-page: 1433 article-title: Conjugation of benzoic acid with glycine in human liver and kidney: a study on the interindividual variability publication-title: Xenobiotica – volume: 40 start-page: 862 issue: 6 year: 1994 end-page: 868 article-title: Age‐related reference values for organic acids in a healthy Turkish pediatric population publication-title: Clin. Chem. – volume: 33 start-page: 319 issue: 5 year: 1984 end-page: 324 article-title: Metabolites and enzyme activities involved in tryptophan metabolism in two strains of mouse publication-title: Ital. J. Biochem. – volume: 35 start-page: 190 issue: 3 year: 1989 end-page: 209 article-title: Comparisons of urinary creatinine, skeletal muscle mass and indices of muscle protein catabolism in rats fed ad libitum, with restricted food intake and deprived of food publication-title: J. Nutr. Sci. Vitaminol. – volume: 64 start-page: 14 issue: 1 year: 1990 end-page: 25 article-title: Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of ‐aminophenol in the Fischer 344 rat publication-title: Arch. Toxicol. – start-page: 153 year: 1979 end-page: 166 – volume: 68 start-page: 349 year: 2000 end-page: 357 article-title: Development of sterotypes and polydipsia in wild caught bank voles and their laboratory‐bred offspring. Is polydipsia a symptom of diabetes mellitus? publication-title: Appl. Animal Behav. Sci. – volume: 46 start-page: 249 issue: 2 year: 2001 end-page: 255 article-title: Abnormal lipid profile of dystrophic cardiac tissue as demonstrated by one‐ and two‐dimensional magic‐angle spinning (1)H NMR spectroscopy publication-title: Magn. Reson. Med. – volume: 17 start-page: 125 issue: 1 year: 1998 end-page: 132 article-title: Biochemical classification of kidney carcinoma biopsy samples using magic‐angle‐spinning H nuclear magnetic resonance spectroscopy publication-title: J. Pharm. Biomed. Anal. – volume: 12 start-page: 387 year: 1982 end-page: 395 article-title: Some observations on the urinary excretion of glycine conjugates by laboratory animals publication-title: Xenobiotica – volume: 748 start-page: 281 issue: 1 year: 2000 end-page: 293 article-title: Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography–mass spectrometry–nuclear magnetic resonance spectroscopy publication-title: J. Chromatogr. B. Biomed. Sci. Applic. – volume: 28 start-page: 527 issue: 5 year: 1998 end-page: 537 article-title: Effect of diet on the urinary excretion of hippuric acid and other dietary‐derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity publication-title: Xenobiotica – volume: 7 start-page: 115 issue: 1 year: 1987 end-page: 121 article-title: Predictive value of random sample urine bile acids corrected by creatinine in liver disease publication-title: Hepatology – volume: 5 start-page: 203 issue: 3 year: 1980 end-page: 214 article-title: Sex difference of mercuric chloride‐induced renal tubular necrosis in rats from the aspect of sex differences in renal mercury concentration and sulfhydryl levels publication-title: J. Toxicol. Sci. – volume: 1 start-page: 153 issue: 2 year: 2002 end-page: 161 article-title: Metabonomics: a platform for studying drug toxicity and gene function publication-title: Nat. Rev. Drug Discov. – volume: 77 start-page: 208 year: 2003 end-page: 217 article-title: An hypothesis for a mechanism underlying hepatotoxin‐induced hypercreatinuria publication-title: Arch. Toxicol. – volume: 21 start-page: 1 year: 1993 end-page: 14 article-title: Effects of two weeks of feed restriction on some common toxicologic parameters in Sprague Dawley rats publication-title: Toxicol. Pathol. – volume: 307 start-page: 491 year: 1980 end-page: 502 article-title: Effects of pregnancy on glucose handling by rat kidneys publication-title: J. Physiol. – volume: 75 start-page: 384A issue: 17 year: 2003 end-page: 391A article-title: So what's the deal with metabonomics? publication-title: Anal. Chem. – volume: 4 start-page: 53 year: 1961 end-page: 120 article-title: Organic acids in blood and urine publication-title: Adv. Clin. Chem. – volume: 19 start-page: 45 issue: 1 year: 2001 end-page: 50 article-title: A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations publication-title: Nat. Biotechnol. – start-page: 170 year: 1998 end-page: 217 – volume: 35 start-page: 242 issue: 2 year: 1989 end-page: 250 article-title: Investigations into the biochemical effects of region‐specific nephrotoxic lesions publication-title: Mol. Pharmac. – volume: 293 start-page: 16 issue: 1 year: 2001 end-page: 21 article-title: Metabolic profiling of genetic disorders: a multitissue H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue publication-title: Anal. Biochem. – volume: 257 start-page: 60 year: 1982 end-page: 67 article-title: Mitochondrial bioenergetics during the initiation of mercuric chloride induced renal injury publication-title: J. Biol. Chem. – article-title: Comparative metabonomics of differential species toxicity of hydrazine in the rat and mouse publication-title: Toxicol. Appl. Pharmac. – volume: 21 start-page: 449 year: 1989 end-page: 501 article-title: High resolution H NMR spectroscopy of biological fluids publication-title: Prog. NMR Spectrasc. – volume: 35 start-page: 283 issue: 2 year: 1986 end-page: 288 article-title: Mechanism of S‐(1,2‐dichlorovinyl)glutathione‐induced nephrotoxicity publication-title: Biochem. Pharmac. – volume: 48 start-page: 155 issue: 1–2 year: 2002 end-page: 171 article-title: Metabolomics‐the link between genotypes and phenotypes publication-title: Plant Mol. Biol. – volume: 490 start-page: 3 year: 2003 end-page: 15 article-title: NMR‐based metabonomic toxicity classification: hierachical cluster analysis and ‐nearest neighbour approaches publication-title: Anal. Chim. Acta – volume: 41 start-page: 14 issue: 4 year: 1995 end-page: 18 article-title: Changes in glycolysis and glycogenolysis in tissues and level of certain hormones in blood and urine from rats with varying lengths of cold adaptation publication-title: Vopr. Med. Khim. – volume: 5 start-page: 410 year: 2000 end-page: 423 article-title: A metabonomic approach to the investigation of drug‐induced phospholipidosis: a NMR spectroscopy and pattern recognition study publication-title: Biomarkers – volume: 8 start-page: 668 year: 2003 end-page: 676 article-title: Opinion: understanding ‘global’ systems biology: metabonomics and the continuum of metabolism publication-title: Nat. Rev. Drug Discov. – volume: 74 start-page: 4588 issue: 17 year: 2002 end-page: 4593 article-title: Cryogenic probe C NMR spectroscopy of urine for metabonomic studies publication-title: Anal. Chem. – volume: 30 start-page: 426 issue: 3 year: 1984 end-page: 432 article-title: Use of high‐resolution proton nuclear magnetic resonance spectroscopy for rapid multi‐component analysis of urine publication-title: Clin. Chem. – volume: 5 start-page: 351 issue: 4 year: 1986 end-page: 359 article-title: Age‐dependent phagocytosis of erythrocytes by the isolated perfused rat liver after galactosamine hepatitis and alpha‐naphthylisothiocyanate cholestasis publication-title: Arch. Gerontol. Geriat. – volume: 192 start-page: 527 issue: 3 year: 1978 end-page: 549 article-title: The effect of sex hormones on the proximal tubules in the rat kidney publication-title: Cell Tissue Res. – volume: 348 start-page: 1740 issue: 9043 year: 1996 end-page: 1741 article-title: Exacerbation of symptoms of fish‐odour syndrome during menstruation publication-title: Lancet – volume: 127 start-page: 357 issue: 3 year: 2000 end-page: 367 article-title: NMR spectroscopy based metabonomic studies on the comparative biochemistry of the kidney and urine of the bank vole ( ), wood mouse ( ), white toothed shrew ( ) and the laboratory rat publication-title: Comp. Biochem. Physiol. B. Biochem. Mol. Biol. – year: 1984 – volume: 252 start-page: 311 issue: 2 year: 1998 end-page: 324 article-title: Regeneration and myogenic cell proliferation correlate with taurine levels in dystrophin‐ and MyoD‐deficient muscles publication-title: Anat. Rec. – volume: 3 start-page: 143 year: 1997 end-page: 146 article-title: Use of proton NMR for determining changes in metabolite excretion profiles induced by dietary changes in the rat publication-title: Pharm. Sci. – volume: 64 start-page: 407 year: 1990 end-page: 411 article-title: Hepatotoxin‐induced hypertaurinuria: a proton NMR study publication-title: Arch. Toxicol. – volume: 47 start-page: 2294 year: 1994 end-page: 2297 article-title: Gut flora and the origin of some urinary aromatic phenolic compounds publication-title: Biochem. Pharmac. – volume: 748 start-page: 295 issue: 1 year: 2000 end-page: 309 article-title: Use of directly coupled ion‐exchange liquid chromatography–mass spectrometry and liquid chromatography‐nuclear magnetic resonance spectroscopy as a strategy for polar metabolite identification publication-title: J. Chromatogr. B. Biomed. Sci. Applic. – volume: 122 start-page: 157 issue: 2 year: 1993 end-page: 163 article-title: Gender‐related differences in cocaine toxicity in the rat publication-title: J. Lab. Clin. Med. – volume: 9 start-page: 1 issue: 1 year: 2004 end-page: 31 article-title: Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis publication-title: Biomarkers – volume: 31 start-page: 264 year: 1976 end-page: 270 article-title: Influence of diet and feed restriction on kidney function of ageing male rats publication-title: J. Gerontol. – volume: 20 start-page: 161 issue: 2 year: 1984 end-page: 171 article-title: Sex and strain differences in mouse kidney: Bowman's capsule morphology and susceptibility to chloroform publication-title: Toxicol. Lett. – volume: 149 start-page: 107 issue: 1 year: 1998 end-page: 119 article-title: Age‐ and gender‐related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats publication-title: Toxicol. Appl. Pharmac. – volume: 253 start-page: 369 issue: 1 year: 1990 end-page: 374 article-title: Alteration of plasma sex hormone levels associated with old age and its effect on hepatic drug metabolism in rats publication-title: J. Pharmac. Exp. Ther. – start-page: 81 year: 1998 end-page: 110 – volume: 20 start-page: 161 issue: 3 year: 2001 end-page: 163 article-title: Gender‐based differences in pharmacokinetics in laboratory animal models publication-title: Int. J. Toxicol. – volume: 70 start-page: 89 issue: 2 year: 1995 end-page: 95 article-title: Comparative studies on the nephrotoxicity of 2‐bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse ( ) publication-title: Arch. Toxicol. – volume: 76 start-page: 89 issue: 2–3 year: 1994 end-page: 99 article-title: Carbon tetrachloride hepatotoxicity as a function of age in female Fischer 344 rats publication-title: Mech. Ageing Dev. – start-page: 88 year: 1998 end-page: 90 – volume: 291 start-page: 17 year: 2001 end-page: 26 article-title: Investigation of the metabolic variation in control rat urine using H NMR spectroscopy publication-title: Anal. Biochem. – volume: 116 start-page: 125 issue: 2 year: 1997 end-page: 134 article-title: H NMR spectroscopic and histopathological studies on propyleneimine‐induced renal papillary necrosis in the rat and the multimammate desert mouse ( ) publication-title: Comp. Biochem. Physiol. C. Pharmac. Toxicol. Endocrinol. – volume: 12 start-page: 13 issue: 1 year: 1989 end-page: 21 article-title: Sleep deprivation in the rat: III. Total sleep deprivation publication-title: Sleep – volume: 69 start-page: 307 issue: 2 year: 1983 end-page: 318 article-title: Acetaminophen nephrotoxicity in the rat. II. Strain differences in nephrotoxicity and metabolism of ‐aminophenol, a metabolite of acetaminophen publication-title: Toxicol. Appl. Pharmac. – start-page: 515 year: 1994 end-page: 560 – volume: 521 start-page: 115 issue: 1–3 year: 2002 end-page: 120 article-title: Earthworm species of the genus can be phenotypically differentiated by metabolic profiling publication-title: FEBS Lett. – volume: 26 start-page: 112 year: 1979 end-page: 121 article-title: Liver injury and lipid metabolism: sex differences in the fatty liver induced by d‐galactosamine publication-title: Acta Hepatogastroenterol. (Stuttg.) – volume: 30 start-page: 34 issue: 5 year: 2001 end-page: 39 article-title: The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases publication-title: Lab. Anim. (NY) – volume: 27 start-page: 2303 year: 1980 end-page: 2309 article-title: Circadian rhythmns of urinary electrolyte excretion in freely moving rats publication-title: Life Sci. – volume: 114C start-page: 7 issue: 1 year: 1996 end-page: 15 article-title: Comparative biochemical effects of low doses of mercury II chloride in the F344 rat and the Multimammate mouse ( ) publication-title: Comp. Biochem. Physiol. – volume: 67 start-page: 329 issue: 2 year: 2002 end-page: 340 article-title: Analysis of strain difference in sensitivity to cadmium‐induced hepatotoxicity in Fischer 344 and Sprague–Dawley rats publication-title: Toxicol. Sci. – volume: 63 start-page: 97 issue: 2 year: 1989 end-page: 106 article-title: Biochemical characterisation of para‐aminophenol‐induced nephrotoxic lesions in the F344 rat publication-title: Arch. Toxicol. – volume: 24 start-page: 182 year: 2001 end-page: 191 article-title: Metabonomic characterisation of genetic variation in toxicological and metabolic responses using probabalistic neural networks publication-title: Chem. Res. Toxicol. – volume: 82 start-page: 374 issue: 5 year: 1975 end-page: 381 article-title: The effect of pregnancy on the renal handling of glucose publication-title: Br. J. Obstet. Gynaecol. – volume: 1 start-page: 4 issue: 1 year: 1994 end-page: 14 article-title: Biomarkers in toxicology publication-title: Toxicol. Ecotoxicol. News – volume: 499 start-page: 13 issue: 1 year: 2002 end-page: 25 article-title: Toxicology and genetic toxicology in the new era of ‘toxicogenomics’: impact of ‘‐omics’ technologies publication-title: Mutat. Res. – volume: 13 start-page: 471 issue: 6 year: 2000 end-page: 478 article-title: Chemometric models for toxicity classification based on NMR spectra of biofluids publication-title: Chem. Res. Toxicol. – volume: 98 start-page: 244 issue: 2 year: 1996 end-page: 250 article-title: H‐NMR detectable fatty acyl chain unsaturation in excised leiomyosarcoma correlate with grade and mitotic activity publication-title: J. Clin. Invest. – volume: 5 start-page: 244 year: 1995 end-page: 246 article-title: Dysfunctional N‐oxidation of trimethylamine and the influence of testosterone treatment in man publication-title: Pharmacogenetics – volume: 1 start-page: 9 year: 1995 end-page: 20 article-title: Gender differences in drug metabolism regulated by growth hormone publication-title: Int. J. Biochem. Cell. Biol. – volume: 1 start-page: 1078 issue: 8594 year: 1988 end-page: 1079 article-title: Contribution of gut bacterial metabolism to human metabolic disease publication-title: Lancet – volume: 64–65 start-page: 661 year: 1992 end-page: 667 article-title: Sex‐specific cytochrome P450 as a cause of sex and species related differences in drug toxicity publication-title: Toxicol. Lett. – volume: 77 start-page: 1 issue: 1–2 year: 1993 end-page: 5 article-title: The correlation between urinary and liver taurine levels and between pre‐dose urinary taurine and liver damage publication-title: Toxicology – volume: 211 start-page: 605 issue: 3 year: 1983 end-page: 615 article-title: High resolution H NMR studies of vertebrate blood and plasma publication-title: Biochem. J. – volume: 36 start-page: 398 issue: 3 year: 1989 end-page: 404 article-title: Quantitative high resolution H NMR urinalysis studies on the biochemical effects of cadmium in the rat publication-title: Mol. Pharmac. – volume: 490 start-page: 109 year: 2003 end-page: 122 article-title: Toxicity classification from metabonomic data using a density superposition approach: ‘CLOUDS’ publication-title: Anal. Chim. Acta – volume: 3 start-page: 433 issue: 5–6 year: 1993 end-page: 438 article-title: 2D H NMR of mdx mouse muscle and myoblast cells during fusion: evidence for a characteristic signal of long chain fatty acids publication-title: Neuromusc. Disord. – volume: 31 start-page: 412 issue: 6 year: 1982 end-page: 418 article-title: Strain differences in the tryptophan metabolite excretion and enzyme activities along the kynurenine pathway in rats publication-title: Ital. J. Biochem. – start-page: 43 year: 2002 end-page: 67 – volume: 47 start-page: 165 year: 1976 end-page: 167 article-title: Effects of acute heat stress on tissue carbohydrate in fasted rats publication-title: Aviation, Space Environ. Med. – volume: 217 start-page: 231 year: 1981 end-page: 237 article-title: Classification of human cancer cells by means of capillary gas chromatography and pattern recognition analysis publication-title: J. Chromatogr. – volume: 49 start-page: 1349 issue: 10 year: 1995 end-page: 1359 article-title: H and H NMR spectroscopic studies on the metabolism and biochemical effects of 2‐bromoethanamine in the rat publication-title: Biochem. Pharmac. – volume: 17 start-page: 414 issue: 2 year: 1991 end-page: 422 article-title: Effect of ageing and diet on proton NMR spectra of rat urine publication-title: Magn. Reson. Med. – volume: 291 start-page: 245 issue: 2 year: 2001 end-page: 252 article-title: Directly coupled high‐performance liquid chromatography and nuclear magnetic resonance spectroscopic with chemometric studies on metabolic variation in Sprague–Dawley rats publication-title: Anal. Biochem. – volume: 530 start-page: 191 year: 2002 end-page: 196 article-title: Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLSDA publication-title: FEBS Lett. – volume: 49 start-page: 1829 issue: 24 year: 1991 end-page: 1834 article-title: Chronopharmacological study of furosemide; (VIII) influence of feeding restriction publication-title: Life Sci. – volume: 11 start-page: 260 year: 1998 end-page: 272 article-title: Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins publication-title: Chem. Res. Toxicol. – volume: 34 start-page: 1283 issue: 10 year: 2002 end-page: 1286 article-title: Is a mouse like any other mouse? publication-title: J. Mol. Cell Cardiol. – volume: 30 start-page: 4 issue: 1 year: 2002 end-page: 7 article-title: Strategic importance of research support through pathology publication-title: Toxicol. Pathol. – volume: 12 start-page: 545 year: 1980 end-page: 551 article-title: Diurnal changes in calcium and phosphate metabolism in rats publication-title: Horm. Metab. Res. – volume: 125 start-page: 492 year: 1985 end-page: 498 article-title: Effect of age and dietary restriction on protein synthesis by isolated kidney cells publication-title: J. Cell. Physiol. – volume: 295 start-page: 194 year: 2001 end-page: 202 article-title: Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high resolution H NMR spectroscopy of urine and pattern recognition publication-title: Anal. Biochem. – volume: 39 start-page: 1 issue: 1 year: 2001 end-page: 40 article-title: Pattern recognition methods and applications in biomedical magnetic resonance publication-title: Prog. NMR Spectrosc. – volume: 132 start-page: 1039 year: 2002 end-page: 1046 article-title: Characterisation of diet‐dependent metabolic serotypes: primary validation of male and female serotypes in independent cohorts of rats publication-title: J. Nutr. – volume: 25 start-page: 68 issue: 1 year: 2002 end-page: 87 article-title: Sleep deprivation in the rat: X. Integration and discussion of the findings publication-title: Sleep – volume: 748 start-page: 233 issue: 1 year: 2000 end-page: 258 article-title: Directly coupled HPLC‐NMR and HPLC‐NMR‐MS in pharmaceutical research and development publication-title: J. Chromatogr. B Biomed. Sci. Applic. – volume: 11 start-page: 235 issue: 4–5 year: 1998 end-page: 244 article-title: Development of a model for classification of toxin‐induced lesions using H NMR spectroscopy of urine combined with pattern recognition publication-title: NMR Biomed. – volume: 11 start-page: 1181 year: 1999 end-page: 1189 article-title: ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli multivariate statistical analysis of biological NMR spectroscopic data publication-title: Xenobiotica – volume: 31 start-page: 684 year: 1991 end-page: 690 article-title: Gender‐related differences in xenobiotic metabolism publication-title: J. Clin. Pharmac. – volume: 25 start-page: 1063 issue: 10 year: 1995 end-page: 1071 article-title: Species‐ and gender‐related differences in amine, alcohol and phenol sulphoconjugations publication-title: Xenobiotica – volume: 484 start-page: 169 issue: 3 year: 2000 end-page: 174 article-title: An NMR‐based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse publication-title: FEBS Lett. – year: 1991 – volume: 16 start-page: 1395 issue: 11 year: 2003 end-page: 1404 article-title: NMR spectroscopic and metabonomic studies of urinary metabolite variation in acclimatising germ free rats publication-title: Chem. Res. Toxicol. – volume: 7 start-page: 295 issue: 7 year: 1994 end-page: 303 article-title: Evaluation of liquid chromatography coupled with high‐field H NMR spectroscopy for drug metabolite detection and characterization: the identification of paracetamol metabolites in urine and bile publication-title: NMR Biomed. – volume: 35 start-page: 297 issue: 3 year: 1983 end-page: 300 article-title: The effect of sleep deprivation and recovery sleep on plasma corticosterone in the rat publication-title: Neurosci. Lett. – year: 1999 |
SSID | ssj0008432 |
Score | 2.3711438 |
SecondaryResourceType | review_article |
Snippet | Strategies such as genomics, proteomics and metabonomics are being applied with increasing frequency in the pharmaceutical industry. For each of these... |
SourceID | proquest pubmed wiley istex |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 143 |
SubjectTerms | Algorithms Animals Body Fluids - metabolism Gene Expression Profiling - methods Humans laboratory animals Magnetic Resonance Spectroscopy - methods metabonomics NMR physiological variation Proteome - metabolism Proteomics - methods Urinalysis - methods Urine - chemistry |
Title | NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition |
URI | https://api.istex.fr/ark:/67375/WNG-6BVR4HCC-H/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fnbm.935 https://www.ncbi.nlm.nih.gov/pubmed/15627238 https://search.proquest.com/docview/19436840 |
Volume | 18 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LTtwwFL2qkFq66WOgZUpbvEDsMiSxncRLGJWOKs0sRrzExvIr1WhEBpEZqeqqn9Bv5Eu4dhKgiAXqKrISW7HPtX1sX58LsMtpTl1WiMg4oSOvIRUJa1nES43TR2zK0vqtgfEkG52wH-f8_EGor0Yf4m7DzfeMMF77Dq50vf9ANFRfDgT118u9jJ6nQ9N74aiChdBkyB_SiLIibq7L-pz7bT4ko74dfz3FLP8lqmGmOXoLF90_Ng4m88FqqQfm9yP5xv-qxDt40_JPctAYzHt44aoerA-7sG89eDVuT9t78DK4h5p6A_RkPL3589dPeZZcuiVaTrjOTDpJclcTZL-k0w6vfpKwZdKNrGTWxUKpyaIierbA5MwS79Deeo1twsnRt-PhKGqjM0TGC95ELlZCWe40T7kTwmhqdSmU4gpXKDlaAFUsKXPtKMekcLFhcakMT_KsTEoj6AdYqxaV2wKCcAlTuIxbnbDEplhukbnMGJpa5GRpH_YCVvKqUeCQ6nruHdJyLs8m32V2eDplo-FQjvqw04Epsdn82Yeq3GJVy0R4qX0W9-Fjg_FdWbiATX3ktT7sBqTuXwRB51QiRhIxkpPDMT4-Pe-zbXgdRF6Da-RnWFter9wXpC9L_TVY6i0NfO7U |
link.rule.ids | 315,786,790,1382,27955,27956,46327,46751 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BEbQXHkuhy6s-VNyyTWI7iY90oQRocli1UImD5VfQqmoWdXclxImfwG_klzB2khYQB8QpshJbsWfG_jwefwOwx2lOXVaIyDihI88hFQlrWcQbjctHbJrGetdAVWflCXt7yk_7qEp_F6bjh7h0uHnLCPO1N3DvkN7_hTVUn08E5dfhBho790b5cnZFHVWwkJwMEUQaUVbE3YVZX3W_r4hw1I_kl79hy9-halhrDu_Ax-EvuxCTs8l6pSfm6x8Ejv_Xjbtwu4eg5EWnM_fgmmtHsDkdMr-N4FbVH7iP4GaIEDXL-6Dravbj23e_6lly7laoPOFGMxlYyd2SIAAmA314-4kEr8kwuZL5kA5lSRYt0fMFFueW-Jj2PnBsG04OXx1Py6hP0BAZz3kTuVgJZbnTPOVOCKOp1Y1QiivcpOSoBFSxpMm1oxyLwsWGxY0yPMmzJmmMoA9go120bgcIykuYwmXc6oQlNsV2i8xlxtDUIixLx_A8CEt-7kg4pLo48zFpOZcf6tcyO3g_Y-V0Kssx7A7SlDhs_vhDtW6xXspEeLZ9Fo_hYSfky7ZwD5v65Gtj2AuiunoROJ1TiTKSKCNZH1T4ePRvn-3CZnlcHcmjN_W7x7AVOF9DpOQT2FhdrN1TRDMr_Syo7U_5nPL0 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFL2CIko3BQZoh1e9qNhlmsR2Ei_plGF4TIRGFKpurPiFRlUzVWdGqljxCXwjX9JrJ2kLYoFYRVZiK_a5to_t63MBdjnNqc0KEWkrVOQ1pCJhDIu4Uzh9xNo547cGJmU2PmTvj_jRjVBfjT7E1Yab7xlhvPYd_My4vRuioep0ICi_DXdYRlO_7jqYXitHFSzEJkMCkUaUFXFzX9Zn3WszIhv1DXnxN2r5O1MNU83oPhx3P9l4mJwMVks10N__0G_8r1o8gM2WgJLXjcU8hFu27sG9YRf3rQfrk_a4vQd3g3-oXjwCVU6mv3789HOeIad2iaYT7jOTTpPcLgjSX9KJh9ffSNgz6YZWMuuCoSzIvCZqNsfkzBDv0d66jT2Gw9Gbz8Nx1IZniLRXvIlsXInKcKt4yq0QWlGjnKgqXuESJUcToBVLXK4s5ZgUNtYsdpXmSZ65xGlBn8BaPa_tNhCES-jCZtyohCUmxXKLzGZa09QgKUv78CpgJc8aCQ5ZnZ94j7Scy6_lW5ntf5my8XAox33Y6cCU2Gz-8KOq7Xy1kInwWvss7sNWg_FVWbiCTX3otT7sBqSuXwRF51QiRhIxkuX-BB9P_-2zHVj_dDCSH9-VH57BRhB8DW6Sz2Fteb6yL5DKLNXLYLSXOwfxow |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=NMR-based+metabonomic+approaches+for+evaluating+physiological+influences+on+biofluid+composition&rft.jtitle=NMR+in+biomedicine&rft.au=Bollard%2C+Mary+E&rft.au=Stanley%2C+Elizabeth+G&rft.au=Lindon%2C+John+C&rft.au=Nicholson%2C+Jeremy+K&rft.date=2005-05-01&rft.issn=0952-3480&rft.volume=18&rft.issue=3&rft.spage=143&rft_id=info:doi/10.1002%2Fnbm.935&rft_id=info%3Apmid%2F15627238&rft.externalDocID=15627238 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0952-3480&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0952-3480&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0952-3480&client=summon |