NMDA receptors in axons: there's no coincidence

• Published in: The Journal of physiology Vol. 599; no. 2; pp. 367 - 387
• Main Authors: Wong, Hovy Ho‐Wai, Rannio, Sabine, Jones, Victoria, Thomazeau, Aurore, Sjöström, P. Jesper
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2021; Wiley
• Subjects: axon; Axons; Calcium; Glutamic acid receptors (ionotropic); Life Sciences; long‐term plasticity; Magnesium; Metabotropic receptors; metabotropic signalling; N-Methyl-D-aspartic acid receptors; Neuralgia; Neurons and Cognition; neuropathic pain; neurotransmitter release; NMDA receptor; presynaptic terminal; Receptors, N-Methyl-D-Aspartate; short‐term plasticity; Subunit structure; Synapses; Therapeutic targets; neuropathic pain; long-term plasticity; presynaptic terminal; axon; NMDA receptor; neurotransmitter release; metabotropic signalling; short-term plasticity

In the textbook view, N‐methyl‐d‐aspartate (NMDA) receptors are postsynaptically located detectors of coincident activity in Hebbian learning. However, controversial presynaptically located NMDA receptors (preNMDARs) have for decades been repeatedly reported in the literature. These preNMDARs have t...