Phospholipid Screening Postcardiac Arrest Detects Decreased Plasma Lysophosphatidylcholine: Supplementation as a New Therapeutic Approach

• Published in: Critical care medicine Vol. 50; no. 2; p. e199
• Main Authors: Nishikimi, Mitsuaki, Yagi, Tsukasa, Shoaib, Muhammad, Takegawa, Ryosuke, Rasul, Rehana, Hayashida, Kei, Okuma, Yu, Yin, Tai, Choudhary, Rishabh C, Becker, Lance B, Kim, Junhwan
• Format: Journal Article
• Language: English
• Published: United States 01.02.2022
• Subjects: Aged; Aged, 80 and over; Animals; Female; Heart Arrest - blood; Heart Arrest - complications; Heart Arrest - metabolism; Humans; Lysophosphatidylcholines - analysis; Lysophosphatidylcholines - blood; Male; Mass Screening - methods; Mass Screening - standards; Mass Screening - statistics & numerical data; Phospholipids - analysis; Phospholipids - blood; Rats; Rats, Sprague-Dawley; Severity of Illness Index

Cardiac arrest and subsequent resuscitation have been shown to deplete plasma phospholipids. This depletion of phospholipids in circulating plasma may contribute to organ damage postresuscitation. Our aim was to identify the diminishment of essential phospholipids in postresuscitation plasma and dev...