Testicular Adrenal Rest Tumors Develop Independently of Long-Term Disease Control: A Longitudinal Analysis of 50 Adult Men With Congenital Adrenal Hyperplasia due to Classic 21-Hydroxylase Deficiency

• Published in: The journal of clinical endocrinology and metabolism Vol. 98; no. 11; pp. E1820 - E1826
• Main Authors: Reisch, Nicole, Rottenkolber, Marietta, Greifenstein, Anais, Krone, Nils, Schmidt, Heinrich, Reincke, Martin, Schwarz, Hans-Peter, Beuschlein, Felix
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.11.2013; Copyright by The Endocrine Society
• Subjects: 17-alpha-Hydroxyprogesterone - blood; Adrenal Hyperplasia, Congenital - blood; Adrenal Hyperplasia, Congenital - complications; Adrenal Hyperplasia, Congenital - drug therapy; Adrenal Rest Tumor - blood; Adrenal Rest Tumor - diagnostic imaging; Adrenal Rest Tumor - etiology; Adult; Child; Child, Preschool; Cross-Sectional Studies; Follow-Up Studies; Glucocorticoids - therapeutic use; Humans; Infant; Infertility, Male - etiology; Longitudinal Studies; Male; Pregnanetriol - blood; Retrospective Studies; Testicular Neoplasms - blood; Testicular Neoplasms - diagnostic imaging; Testicular Neoplasms - etiology; Ultrasonography

Context: Testicular adrenal rest tumors (TARTs) and hypogonadotropic hypogonadism are the two most common causes for male infertility in classic 21-hydroxylase deficiency. Current hypotheses suggest the quality of disease control to be one of the main pathogenic factors for TART development. Objecti...