An introduction to arrays

• Published in: The Journal of pathology Vol. 195; no. 1; pp. 3 - 6
• Main Authors: Maughan, Nicola J., Lewis, Fraser A., Smith, Victoria
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.09.2001; Wiley
• Subjects: Biological and medical sciences; Computational Biology; DNA Fingerprinting; DNA microarray; gene expression profiling; Humans; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Miscellaneous. Technology; Mutation; Neoplasms - classification; Neoplasms - genetics; Oligonucleotide Array Sequence Analysis - methods; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Polymorphism, Genetic; tumourigenesis; Human; DNA chip; Cytogenetics; Technique; Molecular biology; Gene expression; Bibliographic review

DNA microarrays are a new technology that allows the analysis of large numbers of genes at a high resolution by the hybridization of labelled DNA, which may be reverse‐transcribed from mRNA, to a substrate containing thousands of spotted cDNAs or oligonucleotides. The amount of hybridized target is...