An introduction to arrays

DNA microarrays are a new technology that allows the analysis of large numbers of genes at a high resolution by the hybridization of labelled DNA, which may be reverse‐transcribed from mRNA, to a substrate containing thousands of spotted cDNAs or oligonucleotides. The amount of hybridized target is...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of pathology Vol. 195; no. 1; pp. 3 - 6
Main Authors Maughan, Nicola J., Lewis, Fraser A., Smith, Victoria
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.09.2001
Wiley
Subjects
Biological and medical sciences
Computational Biology
DNA Fingerprinting
DNA microarray
gene expression profiling
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Miscellaneous. Technology
Mutation
Neoplasms - classification
Neoplasms - genetics
Oligonucleotide Array Sequence Analysis - methods
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Polymorphism, Genetic
tumourigenesis
Human
DNA chip
Cytogenetics
Technique
Molecular biology
Gene expression
Bibliographic review
Online AccessGet full text

Cover

Abstract DNA microarrays are a new technology that allows the analysis of large numbers of genes at a high resolution by the hybridization of labelled DNA, which may be reverse‐transcribed from mRNA, to a substrate containing thousands of spotted cDNAs or oligonucleotides. The amount of hybridized target is analysed, giving information on gene expression, polymorphisms or mutations present and allowing the gene profiling of different subtypes of disease. This technique has massive implications for the further understanding of the complicated genetic alterations involved in tumourigenesis and other disease processes and also for the generation of accurate prognostic information and optimization of treatment in these situations. Copyright © 2001 John Wiley & Sons, Ltd.
AbstractList DNA microarrays are a new technology that allows the analysis of large numbers of genes at a high resolution by the hybridization of labelled DNA, which may be reverse-transcribed from mRNA, to a substrate containing thousands of spotted cDNAs or oligonucleotides. The amount of hybridized target is analysed, giving information on gene expression, polymorphisms or mutations present and allowing the gene profiling of different subtypes of disease. This technique has massive implications for the further understanding of the complicated genetic alterations involved in tumourigenesis and other disease processes and also for the generation of accurate prognostic information and optimization of treatment in these situations.
DNA microarrays are a new technology that allows the analysis of large numbers of genes at a high resolution by the hybridization of labelled DNA, which may be reverse‐transcribed from mRNA, to a substrate containing thousands of spotted cDNAs or oligonucleotides. The amount of hybridized target is analysed, giving information on gene expression, polymorphisms or mutations present and allowing the gene profiling of different subtypes of disease. This technique has massive implications for the further understanding of the complicated genetic alterations involved in tumourigenesis and other disease processes and also for the generation of accurate prognostic information and optimization of treatment in these situations. Copyright © 2001 John Wiley & Sons, Ltd.
DNA microarrays are a new technology that allows the analysis of large numbers of genes at a high resolution by the hybridization of labelled DNA, which may be reverse-transcribed from mRNA, to a substrate containing thousands of spotted cDNAs or oligonucleotides. The amount of hybridized target is analysed, giving information on gene expression, polymorphisms or mutations present and allowing the gene profiling of different subtypes of disease. This technique has massive implications for the further understanding of the complicated genetic alterations involved in tumourigenesis and other disease processes and also for the generation of accurate prognostic information and optimization of treatment in these situations.DNA microarrays are a new technology that allows the analysis of large numbers of genes at a high resolution by the hybridization of labelled DNA, which may be reverse-transcribed from mRNA, to a substrate containing thousands of spotted cDNAs or oligonucleotides. The amount of hybridized target is analysed, giving information on gene expression, polymorphisms or mutations present and allowing the gene profiling of different subtypes of disease. This technique has massive implications for the further understanding of the complicated genetic alterations involved in tumourigenesis and other disease processes and also for the generation of accurate prognostic information and optimization of treatment in these situations.
Author Smith, Victoria
Maughan, Nicola J.
Lewis, Fraser A.
Author_xml – sequence: 1
  givenname: Nicola J.
  surname: Maughan
  fullname: Maughan, Nicola J.
  organization: Histopathology, The Leeds Teaching Hospitals NHS Trust, Leeds, UK
– sequence: 2
  givenname: Fraser A.
  surname: Lewis
  fullname: Lewis, Fraser A.
  organization: Histopathology, The Leeds Teaching Hospitals NHS Trust, Leeds, UK
– sequence: 3
  givenname: Victoria
  surname: Smith
  fullname: Smith, Victoria
  organization: Genentech Inc., South San Francisco, USA
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14099830$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/11568886$$D View this record in MEDLINE/PubMed
BookMark eNp90c1LwzAYBvAgE91U8OpFdlG8dOa7yXEO3YShgorH8C5NMdq1M-nQ_fd2bE5E9JRDfu9D8j4d1Cqr0iF0SHCPYEzPZ1A_9zTlW6hNsJaJVlq2ULu5ognjJN1FnRhfMMZaC7GDdgkRUikl2-ioX3Z9WYcqm9vaV2W3rroQAiziPtrOoYjuYH3uocery4fBKBnfDq8H_XFiOVE80cApAcI0TCSdUIYzkAQLZaWdaGdVmkIucwrWspxjiSXlnDCRCVA0E8qxPXS6yp2F6m3uYm2mPlpXFFC6ah5NSohmkrEGnv0LidJEpZJK3NDjNZ1Ppi4zs-CnEBbm698NOFkDiBaKPEBpffx2vNmUYsug3srZUMUYXG6sr2G5qDqALwzBZlmAWRZgmgK-H7kZ2GT-psmKvvvCLf505q7_MPrhfazdx8ZDeDUyZakwTzdDM7inWgxGF0azTygboAg
CODEN JPTLAS
CitedBy_id crossref_primary_10_1177_1099800403257458
crossref_primary_10_1373_clinchem_2005_052845
crossref_primary_10_1309_VMLL66Y5KHQ35KUE
crossref_primary_10_1016_S0369_8114_03_00017_8
crossref_primary_10_1016_j_eurpolymj_2014_07_037
crossref_primary_10_1139_w03_095
crossref_primary_10_1016_S1367_5931_02_00323_X
crossref_primary_10_1080_1463677042000189624
crossref_primary_10_1016_S0167_8140_02_00374_2
crossref_primary_10_1021_acs_biomac_5b01116
crossref_primary_10_1038_nrg953
crossref_primary_10_1002_1096_9896_200109_195_1_1__AID_PATH922_3_0_CO_2_G
crossref_primary_10_1093_jhered_esm107
crossref_primary_10_1097_01_pap_0000131825_77317_ee
crossref_primary_10_1016_S0736_5748_02_00041_2
crossref_primary_10_1136_jcp_2005_028324
crossref_primary_10_1007_BF02699933
crossref_primary_10_1021_ac020094q
crossref_primary_10_1016_S0933_3657_03_00036_8
crossref_primary_10_1093_bmb_64_1_59
crossref_primary_10_1517_17530050902915544
crossref_primary_10_1046_j_1365_2273_2002_00606_x
crossref_primary_10_1016_j_jaad_2004_03_038
crossref_primary_10_3892_mco_2017_1275
crossref_primary_10_1007_s10126_007_9042_0
crossref_primary_10_1177_145749690309200103
crossref_primary_10_1097_00129039_200309000_00010
crossref_primary_10_3390_cancers11030363
crossref_primary_10_1111_j_1365_2036_2004_01934_x
crossref_primary_10_3904_kjim_2008_23_4_165
crossref_primary_10_1021_ja2021729
crossref_primary_10_1586_14737159_2_6_531
Cites_doi 10.1038/4429
10.1038/4469
10.1126/science.289.5485.1670
10.1038/35000501
10.1038/4439
10.1038/14385
10.1126/science.270.5235.467
10.1038/4434
10.1002/1096-9896(200109)195:1<66::AID-PATH921>3.0.CO;2-F
10.1073/pnas.93.20.10614
10.1038/ng1296-457
10.1038/35000684
10.1136/bmj.319.7220.1306
10.1038/35015701
10.1038/nbt0198-27
ContentType Journal Article
Copyright Copyright © 2001 John Wiley & Sons, Ltd.
2002 INIST-CNRS
Copyright 2001 John Wiley & Sons, Ltd.
Copyright_xml – notice: Copyright © 2001 John Wiley & Sons, Ltd.
– notice: 2002 INIST-CNRS
– notice: Copyright 2001 John Wiley & Sons, Ltd.
DBID BSCLL
AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7T5
H94
7X8
DOI 10.1002/path.924
DatabaseName Istex
CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Immunology Abstracts
AIDS and Cancer Research Abstracts
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
AIDS and Cancer Research Abstracts
Immunology Abstracts
MEDLINE - Academic
DatabaseTitleList AIDS and Cancer Research Abstracts
MEDLINE

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1096-9896
EndPage 6
ExternalDocumentID 11568886
14099830
10_1002_path_924
PATH924
ark_67375_WNG_CS295CHB_9
Genre reviewArticle
Journal Article
Review
GroupedDBID ---
-~X
.3N
.55
.GA
.GJ
.Y3
05W
0R~
10A
123
1KJ
1L6
1OB
1OC
1ZS
29L
31~
33P
3O-
3SF
3UE
3WU
4.4
4ZD
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5RE
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHHS
AANLZ
AAONW
AASGY
AAXRX
AAZKR
ABCQN
ABCUV
ABEML
ABIJN
ABJNI
ABLJU
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACFBH
ACGFS
ACGOF
ACIWK
ACMXC
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBBV
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADXAS
ADZMN
AEEZP
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFFNX
AFFPM
AFGKR
AFPWT
AFRAH
AFZJQ
AHBTC
AHMBA
AI.
AIACR
AITYG
AIURR
AIWBW
AJBDE
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
AMYDB
ASPBG
ATUGU
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BSCLL
BY8
C45
CS3
D-6
D-7
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
DU5
EBS
EJD
EMOBN
F00
F01
F04
F5P
FEDTE
FUBAC
G-S
G.N
GNP
GODZA
GSXLS
H.X
HBH
HF~
HGLYW
HHY
HHZ
HVGLF
HZ~
IX1
J0M
J5H
JPC
KBYEO
KQQ
L7B
LATKE
LAW
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
M68
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MVM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
NNB
O66
O9-
OHT
OIG
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
PALCI
PQQKQ
Q.N
Q11
QB0
QRW
R.K
RIWAO
RJQFR
ROL
RWI
RX1
SAMSI
SUPJJ
SV3
TEORI
UB1
V2E
VH1
W8V
W99
WBKPD
WH7
WHWMO
WIB
WIH
WIJ
WIK
WJL
WOHZO
WQJ
WRC
WUP
WVDHM
WXI
WXSBR
X7M
XG1
XPP
XV2
YQI
YQJ
ZGI
ZXP
ZZTAW
~IA
~KM
~WT
AAHQN
AAIPD
AAMNL
AANHP
AAYCA
ACRPL
ACYXJ
ADNMO
AFWVQ
ALVPJ
AAYXX
AEYWJ
AGHNM
AGQPQ
AGYGG
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
VXZ
7T5
AAMMB
AEFGJ
AGXDD
AIDQK
AIDYY
H94
7X8
ID FETCH-LOGICAL-c4184-9a421a139ab62b230da61058c6cb9ec877af6f2acc3f40606244135d5a82d58e3
IEDL.DBID DR2
ISSN 0022-3417
IngestDate Fri Jul 11 11:37:46 EDT 2025
Thu Jul 10 22:10:12 EDT 2025
Wed Feb 19 01:24:58 EST 2025
Wed Apr 02 07:17:11 EDT 2025
Tue Jul 01 01:23:45 EDT 2025
Thu Apr 24 23:04:08 EDT 2025
Wed Jan 22 16:22:57 EST 2025
Wed Oct 30 09:47:37 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Human
DNA chip
Cytogenetics
Technique
Molecular biology
Gene expression
Bibliographic review
Language English
License http://doi.wiley.com/10.1002/tdm_license_1.1
CC BY 4.0
Copyright 2001 John Wiley & Sons, Ltd.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4184-9a421a139ab62b230da61058c6cb9ec877af6f2acc3f40606244135d5a82d58e3
Notes istex:128A7AE5DA369882EEE8897B16DF64F6F481B66C
ark:/67375/WNG-CS295CHB-9
ArticleID:PATH924
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Review-3
PMID 11568886
PQID 1891876260
PQPubID 23462
PageCount 4
ParticipantIDs proquest_miscellaneous_71193633
proquest_miscellaneous_1891876260
pubmed_primary_11568886
pascalfrancis_primary_14099830
crossref_citationtrail_10_1002_path_924
crossref_primary_10_1002_path_924
wiley_primary_10_1002_path_924_PATH924
istex_primary_ark_67375_WNG_CS295CHB_9
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate September 2001
PublicationDateYYYYMMDD 2001-09-01
PublicationDate_xml – month: 09
  year: 2001
  text: September 2001
PublicationDecade 2000
PublicationPlace Chichester, UK
PublicationPlace_xml – name: Chichester, UK
– name: Chichester
– name: England
PublicationTitle The Journal of pathology
PublicationTitleAlternate J. Pathol
PublicationYear 2001
Publisher John Wiley & Sons, Ltd
Wiley
Publisher_xml – name: John Wiley & Sons, Ltd
– name: Wiley
References Schena M, Shalon D, Heller R, et al. Parallel human genome analysis: microarray-based expression monitoring of 1000 genes. Proc Natl Acad Sci U S A 1996; 93: 10614-10619.
Southern E, Mir K, Shchepinov M. Molecular interactions on microarrays. Nature Genet 1999; 21 (Suppl): 5-9.
Berns A. Gene expression in diagnosis. Nature 2000; 403: 491-492.
Cheung VG, Morley M, Aguilar F, et al. Making and reading microarrays. Nature Genet 1999; 21 (Suppl): 15-19.
Heiskanen MA, Bittner ML, Chen Y, et al. Detection of gene amplification by genomic hybridization to cDNA microarrays. Cancer Res 2000; 60: 799-802.
Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503-511.
DeRisij, Penland L, Brown PO, et al. Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nature Genet 1996; 14: 457-460.
Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays. Nature 2000; 405: 827-836.
Hacia JG. Resequencing and mutational analysis using oligonucleotide microarrays. Nature Genet 1999; 21 (Suppl): 42-47.
Duggan DJ, Bittner M, Chen Y, et al. Expression profiling using cDNA microarrays. Nature Genet 1999; 21 (Suppl): 10-14.
Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995; 270: 467-470.
Marx J. DNA arrays reveal cancer in its many forms. Science 2000; 289: 1670-1672.
Lewis F, Maughan NJ, Smith V, Hillan K, Quirke P. Unlocking the archive - gene expression in paraffin-embedded tissue. J Pathol 2001; 195: 66-71.
Friend SH. DNA microarrays and expression profiling in clinical practice. Br Med J 1999; 319: 1306-1307.
Pollack J, Perou CM, Alizadeh AA, et al. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nature Genet 1999; 23: 41-46.
Marshall A, Hodgson J. DNA chips - an array of possibilities. Nature Biotechnol 1998; 16: 27-31.
1998; 16
1996; 93
1999; 23
1999; 21
2000; 60
2001; 195
2000; 289
1996; 14
2000; 403
1999; 319
1995; 270
2000; 405
Marshall (10.1002/path.924-BIB9) 1998; 16
Alizadeh (10.1002/path.924-BIB14) 2000; 403
Lewis (10.1002/path.924-BIB15) 2001; 195
Lockhart (10.1002/path.924-BIB1) 2000; 405
Schena (10.1002/path.924-BIB4) 1995; 270
DeRisij (10.1002/path.924-BIB12) 1996; 14
Marx (10.1002/path.924-BIB6) 2000; 289
Pollack (10.1002/path.924-BIB11) 1999; 23
Friend (10.1002/path.924-BIB16) 1999; 319
Hacia (10.1002/path.924-BIB5) 1999; 21
Cheung (10.1002/path.924-BIB7) 1999; 21
Duggan (10.1002/path.924-BIB8) 1999; 21
Schena (10.1002/path.924-BIB3) 1996; 93
Berns (10.1002/path.924-BIB13) 2000; 403
Southern (10.1002/path.924-BIB2) 1999; 21
Heiskanen (10.1002/path.924-BIB10) 2000; 60
References_xml – reference: Berns A. Gene expression in diagnosis. Nature 2000; 403: 491-492.
– reference: Heiskanen MA, Bittner ML, Chen Y, et al. Detection of gene amplification by genomic hybridization to cDNA microarrays. Cancer Res 2000; 60: 799-802.
– reference: Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995; 270: 467-470.
– reference: Hacia JG. Resequencing and mutational analysis using oligonucleotide microarrays. Nature Genet 1999; 21 (Suppl): 42-47.
– reference: Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays. Nature 2000; 405: 827-836.
– reference: Lewis F, Maughan NJ, Smith V, Hillan K, Quirke P. Unlocking the archive - gene expression in paraffin-embedded tissue. J Pathol 2001; 195: 66-71.
– reference: Southern E, Mir K, Shchepinov M. Molecular interactions on microarrays. Nature Genet 1999; 21 (Suppl): 5-9.
– reference: Cheung VG, Morley M, Aguilar F, et al. Making and reading microarrays. Nature Genet 1999; 21 (Suppl): 15-19.
– reference: Duggan DJ, Bittner M, Chen Y, et al. Expression profiling using cDNA microarrays. Nature Genet 1999; 21 (Suppl): 10-14.
– reference: Marshall A, Hodgson J. DNA chips - an array of possibilities. Nature Biotechnol 1998; 16: 27-31.
– reference: Marx J. DNA arrays reveal cancer in its many forms. Science 2000; 289: 1670-1672.
– reference: Friend SH. DNA microarrays and expression profiling in clinical practice. Br Med J 1999; 319: 1306-1307.
– reference: Pollack J, Perou CM, Alizadeh AA, et al. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nature Genet 1999; 23: 41-46.
– reference: DeRisij, Penland L, Brown PO, et al. Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nature Genet 1996; 14: 457-460.
– reference: Schena M, Shalon D, Heller R, et al. Parallel human genome analysis: microarray-based expression monitoring of 1000 genes. Proc Natl Acad Sci U S A 1996; 93: 10614-10619.
– reference: Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503-511.
– volume: 403
  start-page: 491
  year: 2000
  end-page: 492
  article-title: Gene expression in diagnosis
  publication-title: Nature
– volume: 195
  start-page: 66
  year: 2001
  end-page: 71
  article-title: Unlocking the archive – gene expression in paraffin‐embedded tissue
  publication-title: J Pathol
– volume: 21
  start-page: 42
  issue: Suppl
  year: 1999
  end-page: 47
  article-title: Resequencing and mutational analysis using oligonucleotide microarrays
  publication-title: Nature Genet
– volume: 21
  start-page: 15
  issue: Suppl
  year: 1999
  end-page: 19
  article-title: Making and reading microarrays
  publication-title: Nature Genet
– volume: 16
  start-page: 27
  year: 1998
  end-page: 31
  article-title: DNA chips – an array of possibilities
  publication-title: Nature Biotechnol
– volume: 23
  start-page: 41
  year: 1999
  end-page: 46
  article-title: Genome‐wide analysis of DNA copy‐number changes using cDNA microarrays
  publication-title: Nature Genet
– volume: 319
  start-page: 1306
  year: 1999
  end-page: 1307
  article-title: DNA microarrays and expression profiling in clinical practice
  publication-title: Br Med J
– volume: 93
  start-page: 10614
  year: 1996
  end-page: 10619
  article-title: Parallel human genome analysis: microarray‐based expression monitoring of 1000 genes
  publication-title: Proc Natl Acad Sci U S A
– volume: 405
  start-page: 827
  year: 2000
  end-page: 836
  article-title: Genomics, gene expression and DNA arrays
  publication-title: Nature
– volume: 21
  start-page: 10
  issue: Suppl
  year: 1999
  end-page: 14
  article-title: Expression profiling using cDNA microarrays
  publication-title: Nature Genet
– volume: 14
  start-page: 457
  year: 1996
  end-page: 460
  article-title: Use of a cDNA microarray to analyse gene expression patterns in human cancer
  publication-title: Nature Genet
– volume: 403
  start-page: 503
  year: 2000
  end-page: 511
  article-title: Distinct types of diffuse large B‐cell lymphoma identified by gene expression profiling
  publication-title: Nature
– volume: 270
  start-page: 467
  year: 1995
  end-page: 470
  article-title: Quantitative monitoring of gene expression patterns with a complementary DNA microarray
  publication-title: Science
– volume: 289
  start-page: 1670
  year: 2000
  end-page: 1672
  article-title: DNA arrays reveal cancer in its many forms
  publication-title: Science
– volume: 60
  start-page: 799
  year: 2000
  end-page: 802
  article-title: Detection of gene amplification by genomic hybridization to cDNA microarrays
  publication-title: Cancer Res
– volume: 21
  start-page: 5
  issue: Suppl
  year: 1999
  end-page: 9
  article-title: Molecular interactions on microarrays
  publication-title: Nature Genet
– volume: 21
  start-page: 5
  year: 1999
  ident: 10.1002/path.924-BIB2
  publication-title: Nature Genet
  doi: 10.1038/4429
– volume: 21
  start-page: 42
  year: 1999
  ident: 10.1002/path.924-BIB5
  publication-title: Nature Genet
  doi: 10.1038/4469
– volume: 289
  start-page: 1670
  year: 2000
  ident: 10.1002/path.924-BIB6
  publication-title: Science
  doi: 10.1126/science.289.5485.1670
– volume: 60
  start-page: 799
  year: 2000
  ident: 10.1002/path.924-BIB10
  publication-title: Cancer Res
– volume: 403
  start-page: 503
  year: 2000
  ident: 10.1002/path.924-BIB14
  publication-title: Nature
  doi: 10.1038/35000501
– volume: 21
  start-page: 15
  year: 1999
  ident: 10.1002/path.924-BIB7
  publication-title: Nature Genet
  doi: 10.1038/4439
– volume: 23
  start-page: 41
  year: 1999
  ident: 10.1002/path.924-BIB11
  publication-title: Nature Genet
  doi: 10.1038/14385
– volume: 270
  start-page: 467
  year: 1995
  ident: 10.1002/path.924-BIB4
  publication-title: Science
  doi: 10.1126/science.270.5235.467
– volume: 21
  start-page: 10
  year: 1999
  ident: 10.1002/path.924-BIB8
  publication-title: Nature Genet
  doi: 10.1038/4434
– volume: 195
  start-page: 66
  year: 2001
  ident: 10.1002/path.924-BIB15
  publication-title: J Pathol
  doi: 10.1002/1096-9896(200109)195:1<66::AID-PATH921>3.0.CO;2-F
– volume: 93
  start-page: 10614
  year: 1996
  ident: 10.1002/path.924-BIB3
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.93.20.10614
– volume: 14
  start-page: 457
  year: 1996
  ident: 10.1002/path.924-BIB12
  publication-title: Nature Genet
  doi: 10.1038/ng1296-457
– volume: 403
  start-page: 491
  year: 2000
  ident: 10.1002/path.924-BIB13
  publication-title: Nature
  doi: 10.1038/35000684
– volume: 319
  start-page: 1306
  year: 1999
  ident: 10.1002/path.924-BIB16
  publication-title: Br Med J
  doi: 10.1136/bmj.319.7220.1306
– volume: 405
  start-page: 827
  year: 2000
  ident: 10.1002/path.924-BIB1
  publication-title: Nature
  doi: 10.1038/35015701
– volume: 16
  start-page: 27
  year: 1998
  ident: 10.1002/path.924-BIB9
  publication-title: Nature Biotechnol
  doi: 10.1038/nbt0198-27
SSID ssj0009955
Score 1.8775765
SecondaryResourceType review_article
Snippet DNA microarrays are a new technology that allows the analysis of large numbers of genes at a high resolution by the hybridization of labelled DNA, which may be...
SourceID proquest
pubmed
pascalfrancis
crossref
wiley
istex
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3
SubjectTerms Biological and medical sciences
Computational Biology
DNA Fingerprinting
DNA microarray
gene expression profiling
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Miscellaneous. Technology
Mutation
Neoplasms - classification
Neoplasms - genetics
Oligonucleotide Array Sequence Analysis - methods
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Polymorphism, Genetic
tumourigenesis
Title An introduction to arrays
URI https://api.istex.fr/ark:/67375/WNG-CS295CHB-9/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpath.924
https://www.ncbi.nlm.nih.gov/pubmed/11568886
https://www.proquest.com/docview/1891876260
https://www.proquest.com/docview/71193633
Volume 195
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dSxwxEA-iUHyp2s-1VbdQ6tOe-5Vs8nge1UNQxCoKPoRJNgtF2ZP7AO1f35nN7h0nCqVP-zL7MZlJ5jfJ7G8Y-65EGUNc2MgkmKLkyshIGmUjxY1Lc2tdBbTfcXomhlf5yQ2_aasq6V8Yzw8x33CjmdGs1zTBwUwOFqSh1LG3h9kDLr9UqkV46GLBHKUU53Oi8DwpOt7ZOD3oblyKRGs0qI9UGQkTHJzKd7V4CXYuo9gmDB1tsNtOAV99ctebTU3P_nnG7fh_Gm6yty06DfvenbbYiqvfsTen7fn7exb06_A31baXnnQ2nI5CGI_hafKBXR39vBwMo7a5QmRzzOoiBXmaAOI_MCI1mIiUgEiKSyusUc7KooBKVClYm1UY9GOBOCDJeMlBpiWXLvvIVutR7T6z0Km4NOiRNsfkJC8VOKjKBIQoClqHIWD73UBr2zKPUwOMe-05k1NNmmrUNGDf5pIPnm3jBZkfja3mAjC-o-q0guvrs2M9-JUqPhgeahWw3SVjLp6IOa2SWYxv66yrcVLRSQnUbjSb6ESqhMKEQJm9V2SKBLGvyLKAffKOsXg-5sRSSoFf2pj3VVX0ef9yiNftfxX8wtZ9DRzVuH1lq9PxzO0gKJqa3cb9_wIvEwex
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VVoJeyruERxskBKds87Jji9OyogTorhBsRQ9I1thxpKpVFu1DKvx6xvFmV4taCXHKZeJkPJ7MN_bkG4BXklcxxoWJdEIpSi61iISWJpJM2zQ3xtbo9juGI16e5p_O2NkWvO3-hfH8EKsNN-cZ7ffaObjbkD5as4a6lr09Sh9uwY5r6N3mU1_X3FFSMraiCs-TomOejdOj7s6NWLTjpvXK1UbijKan9n0trgOemzi2DUTHd-FHp4KvP7noLea6Z37_xe74nzreg70lQA37fkXdhy3bPIDbw-UR_EMI-k147srbK887G84nIU6n-Gv2CE6P348HZbTsrxCZnBK7SGKeJkgQEDVPNeUiFRKYYsJwo6U1oiiw5nWKxmQ1xf2YExRIMlYxFGnFhM0ew3YzaewTCK2MK02L0uSUn-SVRIt1lSDnReE-xRjAm26mlVmSj7seGJfK0yanymmqSNMAXq4kf3rCjWtkXrfGWgng9MIVqBVMfR99UINvqWSD8p2SARxsWHM9IqW1UmQxPa0zryK_cocl2NjJYqYSIRMXKTjJHN4gUyQEf3mWBbDvV8Z6fEqLhRCc3rS1742qqC_9cUnXp_8qeAh3yvHwRJ18HH1-Bru-JM6VvD2H7fl0YV8QRprrg9YX_gCajQvM
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BK1VcaHmnlDZICE7Z5mE79nHZsiyPripoRaUeLL8ioVbZah9S4dczjpNdLWolxCmXiZPxzMTf2JNvAN4IZlOVlibRGaYoRGiecC1MIqh2OTHGVcrvdxyP2eiMfD6n521Vpf8XJvBDLDfcfGQ032sf4Ne2OlyRhvqOvT3MHu7DJmEp9x599G1FHSUEpUumcJKVHfFsmh92d64tRZt-Vm98aaSa4exUoa3FbbhzHcY269BwGy46DUL5yWVvMdc98_svcsf_U3EHHrbwNO4Hf3oE91z9GLaO2wP4JxD16_inL263gXU2nk9iNZ2qX7OncDb8cDoYJW13hcQQTOsSoUieKQSASrNcYyZiFUIpyg0zWjjDy1JVrMqVMUWFq37KEAhkBbVU8dxS7opnsFFPavcCYidSq9ElDcHshFihnKpsphgrS_8hVhG86yZampZ63HfAuJKBNDmXXlOJmkbweil5Heg2bpF529hqKaCml748raTyx_ijHHzPBR2M3ksRwf6aMVcjYlIreJHi0zrrSowqf1SiajdZzGTGRebXCYYyB3fIlBmCX1YUETwPjrEaH5NizjnDN23Me6cq8qR_OsLr7r8KHsDWydFQfv00_vISHoR6OF_vtgcb8-nCvUKANNf7TST8AY_DCoQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+introduction+to+arrays&rft.jtitle=The+Journal+of+pathology&rft.au=Maughan%2C+N+J&rft.au=Lewis%2C+F+A&rft.au=Smith%2C+V&rft.date=2001-09-01&rft.issn=0022-3417&rft.volume=195&rft.issue=1&rft.spage=3&rft_id=info:doi/10.1002%2Fpath.924&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3417&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3417&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3417&client=summon