In Vitro Antifungal Susceptibility of Cryptococcus gattii

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Published inJournal of Clinical Microbiology Vol. 42; no. 10; pp. 4815 - 4817
Main Authors Trilles, Luciana, Fernández-Torres, Belkys, dos Santos Lazéra, Márcia, Wanke, Bodo, Guarro, Josep
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.10.2004
Subjects
Antifungal Agents - pharmacology
Biological and medical sciences
Cryptococcus - drug effects
Cryptococcus gattii
Cryptococcus neoformans - drug effects
Fundamental and applied biological sciences. Psychology
Humans
Infectious diseases
Medical sciences
Microbial Sensitivity Tests
Microbiology
Mycology
Quinazolines - pharmacology
Thiazoles - pharmacology
Triazoles - pharmacology
Microbiology
Antifungal agent
Sensitivity
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Abstract Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JCM .asm.org, visit: JCM       
AbstractList We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains with those for C. neoformans . MICs were determined by a microdilution reference method. Albaconazole and ravuconazole (MICs of 0.04 and 0.05 μg/ml, respectively) showed the best activities. Micafungin showed no activity (MIC of >128 μg/ml). In general, C. gattii was less susceptible than C. neoformans to all drugs tested, with the exception of amphotericin B and flucytosine.
Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JCM .asm.org, visit: JCM       
We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains with those for C. neoformans. MICs were determined by a microdilution reference method. Albaconazole and ravuconazole (MICs of 0.04 and 0.05 microg/ml, respectively) showed the best activities. Micafungin showed no activity (MIC of >128 microg/ml). In general, C. gattii was less susceptible than C. neoformans to all drugs tested, with the exception of amphotericin B and flucytosine.
We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains with those for C. neoformans. MICs were determined by a microdilution reference method. Albaconazole and ravuconazole (MICs of 0.04 and 0.05 mu g/ml, respectively) showed the best activities. Micafungin showed no activity (MIC of >128 mu g/ml). In general, C. gattii was less susceptible than C. neoformans to all drugs tested, with the exception of amphotericin B and flucytosine.
ABSTRACT We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains with those for C. neoformans . MICs were determined by a microdilution reference method. Albaconazole and ravuconazole (MICs of 0.04 and 0.05 μg/ml, respectively) showed the best activities. Micafungin showed no activity (MIC of >128 μg/ml). In general, C. gattii was less susceptible than C. neoformans to all drugs tested, with the exception of amphotericin B and flucytosine.
We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains with those for C. neoformans. MICs were determined by a microdilution reference method. Albaconazole and ravuconazole (MICs of 0.04 and 0.05 microg/ml, respectively) showed the best activities. Micafungin showed no activity (MIC of >128 microg/ml). In general, C. gattii was less susceptible than C. neoformans to all drugs tested, with the exception of amphotericin B and flucytosine.
Author Bodo Wanke
Josep Guarro
Belkys Fernández-Torres
Luciana Trilles
Márcia dos Santos Lazéra
AuthorAffiliation Serviçio de Micología Médica, Instituto de Pesquisa Clínica Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil, 1 Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain 2
AuthorAffiliation_xml – name: Serviçio de Micología Médica, Instituto de Pesquisa Clínica Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil, 1 Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain 2
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  givenname: Márcia
  surname: dos Santos Lazéra
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Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21, 43201, Reus, Spain. Phone: 34-977-759359. Fax: 34-977-759322. E-mail: jga@fmcs.urv.es.
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Snippet Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains...
ABSTRACT We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these...
We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains...
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SubjectTerms Antifungal Agents - pharmacology
Biological and medical sciences
Cryptococcus - drug effects
Cryptococcus gattii
Cryptococcus neoformans - drug effects
Fundamental and applied biological sciences. Psychology
Humans
Infectious diseases
Medical sciences
Microbial Sensitivity Tests
Microbiology
Mycology
Quinazolines - pharmacology
Thiazoles - pharmacology
Triazoles - pharmacology
Title In Vitro Antifungal Susceptibility of Cryptococcus gattii
URI http://jcm.asm.org/content/42/10/4815.abstract
https://www.ncbi.nlm.nih.gov/pubmed/15472349
https://search.proquest.com/docview/17704621
https://search.proquest.com/docview/66958961
https://pubmed.ncbi.nlm.nih.gov/PMC522305
Volume 42
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