Predicting the warfarin maintenance dose in elderly inpatients at treatment initiation: accuracy of dosing algorithms incorporating or not VKORC1/CYP2C9 genotypes

• Published in: Journal of thrombosis and haemostasis Vol. 9; no. 4; pp. 711 - 718
• Main Authors: MOREAU, C., PAUTAS, E., GOUIN‐THIBAULT, I., GOLMARD, J.‐L., MAHÉ, I., MULOT, C., LORIOT, M.‐A., SIGURET, V.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2011
• Subjects: Aged; algorithm; Algorithms; Anticoagulants - administration & dosage; Anticoagulants - therapeutic use; Aryl Hydrocarbon Hydroxylases - genetics; CYP2C9; Cytochrome P-450 CYP2C9; elderly; Female; Genotype; Humans; Inpatients; INR; Male; Mixed Function Oxygenases - genetics; Vitamin K Epoxide Reductases; VKORC1; warfarin; Warfarin - administration & dosage; Warfarin - therapeutic use

Background: Initiating warfarin is challenging in frail elderly patients because of low‐dose requirements and interindividual variability. Objectives: We investigated whether incorporating VKORC1 and CYP2C9 genotype information in different models helped to predict the warfarin maintenance dose when...