Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 4; pp. 960 - 965
• Main Authors: Cheung, Sarah K. C., Chuang, Po-Kai, Huang, Han-Wen, Hwang-Verslues, Wendy W., Cho, Candy Hsin-Hua, Yang, Wen-Bin, Shen, Chia-Ning, Hsiao, Michael, Hsu, Tsui-Ling, Chang, Chuan-Fa, Wong, Chi-Huey
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 26.01.2016; National Acad Sciences
• Subjects: Animals; Antigens, Tumor-Associated, Carbohydrate - analysis; Apoptosis; Base Sequence; Biological Sciences; Biomarkers, Tumor - analysis; Breast Neoplasms - pathology; Cell Line, Tumor; Female; Galactosyltransferases - analysis; Humans; Mice; Molecular Sequence Data; Neoplastic Stem Cells - chemistry; Stage-Specific Embryonic Antigens - analysis; globo-series; glycolipids; cancer-specific

The discovery of cancer stem cells (CSCs), which are responsible for self-renewal and tumor growth in heterogeneous cancer tissues, has stimulated interests in developing new cancer therapies and early diagnosis. However, the markers currently used for isolation of CSCs are often not selective enoug...