Platelet apoptosis by cold‐induced glycoprotein Ibα clustering

• Published in: Journal of thrombosis and haemostasis Vol. 8; no. 11; pp. 2554 - 2562
• Main Authors: VAN DER WAL, D. E., DU, V. X., LO, K. S. L., RASMUSSEN, J. T., VERHOEF, S., AKKERMAN, J. W. N.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2010
• Subjects: 14-3-3 Proteins - metabolism; 14‐3‐3; Acetylglucosamine - metabolism; Apoptosis; Bad; bcl-Associated Death Protein - metabolism; Binding Sites; Blood Platelets - cytology; Caspase 9 - metabolism; Cluster Analysis; Cold Temperature; cold‐storage; Flow Cytometry - methods; glycoprotein Ibα; Humans; Mitochondria - metabolism; Phosphorylation; platelet; Platelet Glycoprotein GPIb-IX Complex - metabolism; thromboxane A2; Thromboxane A2 - metabolism

Background:  Cold‐storage of platelets followed by rewarming induces changes in Glycoprotein (GP) Ibα‐distribution indicative of receptor clustering and initiates thromboxane A2‐formation. GPIbα is associated with 14‐3‐3 proteins, which contribute to GPIbα‐signaling and in nucleated cells take part...