Association of envelope-specific B-cell differentiation and viral selective pressure signatures in HIV-1 CRF01_AE infection

• Published in: AIDS (London) Vol. 36; no. 12; pp. 1629 - 1641
• Main Authors: Hau, Trang Thi Thu, Nishizawa, Masako, Harada, Shigeyoshi, Phan, My Ha, Kanno, Yoshiaki, Nomura, Takushi, Matsuoka, Saori, Kawana-Tachikawa, Ai, Hall, William W., Matano, Tetsuro, Nguyen, Lan Anh Thi, Yamamoto, Hiroyuki
• Format: Journal Article
• Language: English
• Published: England Lippincott Williams & Wilkins 01.10.2022
• Subjects: Antibodies, Neutralizing; Cell Differentiation; HIV Antibodies; HIV Infections; HIV-1 - genetics; Humans

In HIV type 1 (HIV-1) infection, virus-specific B-cell and neutralizing antibody (NAb) responses are impaired but exert selective pressure on target viral Envelope (Env) resulting in prominent sequence diversification among geographical areas. The basal induction patterns of HIV Env-specific B cells...