The orf virus (ORFV) protein OV20.0 interacts with the microprocessor complex subunit DGCR8 to regulate miRNA biogenesis and ORFV infection

• Published in: FEBS letters Vol. 595; no. 23; pp. 2897 - 2908
• Main Authors: Liao, Guan‐Ru, Tseng, Yeu‐Yang, Tseng, Ching‐Yu, Lo, Chen‐Yu, Hsu, Wei‐Li
• Format: Journal Article
• Language: English
• Published: England 01.12.2021
• Subjects: A549 Cells; Animals; biogenesis; DGCR8; Dogs; double‐stranded RNA; Ecthyma, Contagious - metabolism; Ecthyma, Contagious - virology; HEK293 Cells; Humans; innate immunity; Madin Darby Canine Kidney Cells; microRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Orf virus; Orf virus - pathogenicity; Orthomyxoviridae; OV20.0; Protein Binding; RNA, Messenger - metabolism; RNA-Binding Proteins - metabolism; Viral Proteins - metabolism; DGCR8; orf virus; double-stranded RNA; innate immunity; OV20.0

Cellular double‐stranded RNA‐binding proteins (DRBPs) play important roles in the regulation of innate immune responses and microRNA (miRNA) biogenesis. The current study aimed to understand whether OV20.0, a DRBP of orf virus (ORFV), is involved in cellular RNA biogenesis via association with host...