Effect of hydroxyurea treatment on renal function parameters: Results from the multi-center placebo-controlled BABY HUG clinical trial for infants with sickle cell anemia

• Published in: Pediatric blood & cancer Vol. 59; no. 4; pp. 668 - 674
• Main Authors: Alvarez, Ofelia, Miller, Scott T., Wang, Winfred C., Luo, Zhaoyu, McCarville, M. Beth, Schwartz, George J., Thompson, Bruce, Howard, Thomas, Iyer, Rathi V., Rana, Sohail R., Rogers, Zora R., Sarnaik, Sharada A., Thornburg, Courtney D., Ware, Russell E.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2012
• Subjects: Anemia, Sickle Cell - complications; Anemia, Sickle Cell - drug therapy; Anemia, Sickle Cell - physiopathology; Anemia, Sickle Cell - urine; Antisickling Agents - therapeutic use; Creatinine - blood; Cystatin C - blood; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; hydroxyurea; Hydroxyurea - therapeutic use; Infant; Kidney - diagnostic imaging; Kidney - physiopathology; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - prevention & control; kidney function; Male; Osmolar Concentration; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Pentetate; Ultrasonography; urine osmolality

Background Children with sickle cell anemia (SCA) often develop hyposthenuria and renal hyperfiltration at an early age, possibly contributing to the glomerular injury and renal insufficiency commonly seen later in life. The Phase III randomized double‐blinded Clinical Trial of Hydroxyurea in Infant...