Epstein-Barr virus-encoded miR-BART11 promotes tumor-associated macrophage-induced epithelial-mesenchymal transition via targeting FOXP1 in gastric cancer

• Published in: Virology (New York, N.Y.) Vol. 548; pp. 6 - 16
• Main Authors: Song, Yali, Li, Qiao, Liao, Shan, Zhong, Kangying, Jin, Yaxiong, Zeng, Tingting
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2020
• Subjects: cadherins; carcinoma; EBV-miR-BART11; EMT; Epithelial-mesenchymal transition; Forkhead box protein P1; FOXP1; Gastric carcinoma; Human gammaherpesvirus 4; interleukin-6; macrophages; Metastasis; microRNA; phenotype; prognosis; secretion; snails; stomach neoplasms; transcription factors; virology; Epithelial-mesenchymal transition; Gastric carcinoma; EBV-miR-BART11; Metastasis; EMT; Forkhead box protein P1; FOXP1

Gastric carcinoma (GC) is an Epstein-Barr virus (EBV)-associated malignancy characterized by early metastasis. Unlike that of cellular micro(mi)RNAs, the role of viral miRNAs in epithelial-mesenchymal transition (EMT) and metastasis in cancers has not been fully investigated. In this study, we eluci...