Oxidative stress, NF-κB signaling, NLRP3 inflammasome, and caspase apoptotic pathways are activated in mammary gland of ketotic Holstein cows

• Published in: Journal of dairy science Vol. 104; no. 1; pp. 849 - 861
• Main Authors: Sun, Xudong, Tang, Yan, Jiang, Chunhui, Luo, Shengbin, Jia, Hongdou, Xu, Qiushi, Zhao, Chenxu, Liang, Yusheng, Cao, Zhijun, Shao, Guang, Loor, Juan J., Xu, Chuang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021
• Subjects: 3-Hydroxybutyric Acid - blood; Animals; apoptosis; Apoptosis - physiology; blood serum; caspase-1; caspase-3; caspase-9; Caspases - metabolism; catalase; Cattle; Cattle Diseases - metabolism; Female; glucose; glutathione peroxidase; Holstein; hydrogen peroxide; inflammasomes; Inflammasomes - metabolism; inflammation; Inflammation - metabolism; Inflammation - veterinary; interleukin-6; ketosis; Ketosis - metabolism; Ketosis - pathology; Ketosis - veterinary; Lactation - physiology; lactose; malondialdehyde; mammary gland; mammary glands; Mammary Glands, Animal - chemistry; Mammary Glands, Animal - metabolism; Mammary Glands, Animal - pathology; milk; Milk - chemistry; milk fat; milk proteins; milk yield; NF-kappa B - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; oxidative stress; Oxidative Stress - physiology; Signal Transduction; superoxide dismutase; apoptosis; ketosis; mammary gland; inflammation; oxidative stress

Ketosis is a serious metabolic disorder characterized by systemic and hepatic oxidative stress, inflammation, and apoptosis, as well as reduced milk yield. Because of the paucity of data on mammary responses during ketosis, the aim of this study was to evaluate alterations in oxidative stress, NF-κB...