Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth

• Published in: Cancer research (Chicago, Ill.) Vol. 71; no. 12; pp. 4138 - 4149
• Main Authors: Chen, Juan, Zhang, Bin, Wong, Nathalie, Lo, Anthony W.I., To, Ka-Fai, Chan, Anthony W.H., Ng, Margaret H.L., Ho, Cecilia Y.S., Cheng, Suk-Hang, Lai, Paul B.S., Yu, Jun, Ng, Ho-Keung, Ling, Ming-Tat, Huang, Ai-Long, Cai, Xue-Fei, Ko, Ben C.B.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.06.2011
• Subjects: Antineoplastic agents; Apoptosis; Biological and medical sciences; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Doxorubicin - pharmacology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Pharmacology. Drug treatments; Sirtuin 1 - analysis; Sirtuin 1 - physiology; Telomerase - analysis; Telomerase - physiology; Telomere; Telomere-Binding Proteins - analysis; Telomere-Binding Proteins - physiology; Tumor Suppressor Protein p53 - physiology; Tumors; Up-Regulation; Cell proliferation; Hepatic disease; Hepatocellular carcinoma; Maintenance; Malignant tumor; Essential; Telomere; Sirtuin; Liver cancer; Tumor growth; Digestive diseases; Tumor cell; Cancer

Hepatocellular carcinoma (HCC) is a highly malignant tumor with a poor prognosis. Treatment of HCC is complicated by the fact that the disease is often diagnosed at an advanced stage when it is no longer amenable to curative surgery, and current systemic chemotherapeutics are mostly inefficacious. S...