PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

• Published in: The Journal of experimental medicine Vol. 210; no. 4; pp. 757 - 774
• Main Authors: Zinselmeyer, Bernd H., Heydari, Sara, Sacristán, Catarina, Nayak, Debasis, Cammer, Michael, Herz, Jasmin, Cheng, Xiaoxiao, Davis, Simon J., Dustin, Michael L., McGavern, Dorian B.
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 08.04.2013
• Subjects: Animals; Antigens, Differentiation - genetics; Antigens, Differentiation - immunology; B7-H1 Antigen - genetics; B7-H1 Antigen - immunology; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Cell Movement - genetics; Cell Movement - immunology; Immunity, Cellular - genetics; Interferon-gamma - genetics; Interferon-gamma - immunology; Lymphocytic Choriomeningitis - genetics; Lymphocytic Choriomeningitis - immunology; Lymphocytic choriomeningitis virus - genetics; Lymphocytic choriomeningitis virus - immunology; Mice; Mice, Knockout; Programmed Cell Death 1 Receptor; Viral Load - genetics; Viral Load - immunology

Immune responses to persistent viral infections and cancer often fail because of intense regulation of antigen-specific T cells—a process referred to as immune exhaustion. The mechanisms that underlie the induction of exhaustion are not completely understood. To gain novel insights into this process...