Synaptogenesis in Drosophila: Coupling genetics and electrophysiology

Drosophila is one of the most fully described eukaryotic organisms and, as a system, offers the most advanced genetic and molecular techniques.In particular, Drosophila embryonic development has been subject to intensive genetic and molecular examination. Drosophila is also one of the few geneticall...

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Published inJournal of physiology (Paris) Vol. 88; no. 2; pp. 123 - 139
Main Author Broadie, K.S.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Paris Elsevier Ltd 1994
Elsevier
Subjects
Animals
Biological and medical sciences
development
Drosophila
Drosophila - embryology
Drosophila - physiology
Electrophysiology
embryo
Fundamental and applied biological sciences. Psychology
Genetics
Insecta
Invertebrates
Life cycle. Embryology. Development
neuromuscular junction
Physiology. Development
Synapses - physiology
synaptogenesis
embryo
development
neuromuscular junction
synaptogenesis
Drosophila
Embryonic development
Embryo
Synaptogenesis
Insecta
Electrophysiology
Nervous system
Neuromuscular junction
Drosophilidae
Synapse
Regulation(control)
Gene
Arthropoda
Invertebrata
Diptera
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Abstract Drosophila is one of the most fully described eukaryotic organisms and, as a system, offers the most advanced genetic and molecular techniques.In particular, Drosophila embryonic development has been subject to intensive genetic and molecular examination. Drosophila is also one of the few genetically malleable organisms to permit electrophysiological investigation and so allow detailed physiological characterization of specific molecular lesions. These two fields, the developmental and electrophysiological, are being coupled for the first time to examine a key aspect of neural development, synaptogenesis. Here, I describe synaptogenesis in the Drosophila embryo at the identified neuromuscular junction. I focus particular attention on the use of known genetic mutations to dissect the mechanisms of synapse formation. This simple, well-characterized synapse is already proving valuable in describing the defects of mutations in genes essential for synaptic development and function. In the long term, this system will allow us to systematically mutate the Drosophila genome to identify and describe the genetic and molecular pathways directing the construction of a synapse.
AbstractList Drosophila is one of the most fully described eukaryotic organisms and, as a system, offers the most advanced genetic and molecular techniques.In particular, Drosophila embryonic development has been subject to intensive genetic and molecular examination. Drosophila is also one of the few genetically malleable organisms to permit electrophysiological investigation and so allow detailed physiological characterization of specific molecular lesions. These two fields, the developmental and electrophysiological, are being coupled for the first time to examine a key aspect of neural development, synaptogenesis. Here, I describe synaptogenesis in the Drosophila embryo at the identified neuromuscular junction. I focus particular attention on the use of known genetic mutations to dissect the mechanisms of synapse formation. This simple, well-characterized synapse is already proving valuable in describing the defects of mutations in genes essential for synaptic development and function. In the long term, this system will allow us to systematically mutate the Drosophila genome to identify and describe the genetic and molecular pathways directing the construction of a synapse.
Drosophila is one of the most fully described eukaryotic organisms and, as a system, offers the most advanced genetic and molecular techniques. In particular, Drosophila embryonic development has been subject to intensive genetic and molecular examination. Drosophila is also one of the few genetically malleable organisms to permit electrophysiological investigation and so allow detailed physiological characterization of specific molecular lesions. These two fields, the developmental and electrophysiological, are being coupled for the first time to examine a key aspect of neural development, synaptogenesis. Here, I describe synaptogenesis in the Drosophila embryo at the identified neuromuscular junction. I focus particular attention on the use of known genetic mutations to dissect the mechanisms of synapse formation. This simple, well-characterized synapse is already proving valuable in describing the defects of mutations in genes essential for synaptic development and function. In the long term, this system will allow us to systematically mutate the Drosophila genome to identify and describe the genetic and molecular pathways directing the construction of a synapse.
Drosophila is one of the most fully described eukaryotic organisms and, as a system, offers the most advanced genetic and molecular techniques. In particular, Drosophila embryonic development has been subject to intensive genetic and molecular examination. Drosophila is also one of the few genetically malleable organisms to permit electrophysiological investigation and so allow detailed physiological characterization of specific molecular lesions. These two fields, the development and electrophysiological, are being coupled for the first time to examine a key aspect of neural development, synaptogenesis. Here, I describe synaptogenesis in the Drosophila embryo at the identified neuromuscular junction. I focus particular attention on the use of known genetic mutations to dissect the mechanisms of synapse formation. This simple, well-characterized synapse is already proving valuable in describing the defects of mutations in genes essential for synaptic development and function. In the long term, this system will allow us to systematically mutate the Drosophila genome to identify and describe the genetic and molecular pathways directing the construction of a synapse.
Author Broadie, K.S.
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Issue 2
Keywords embryo
development
neuromuscular junction
synaptogenesis
Drosophila
Embryonic development
Embryo
Synaptogenesis
Insecta
Electrophysiology
Nervous system
Neuromuscular junction
Drosophilidae
Synapse
Regulation(control)
Gene
Arthropoda
Invertebrata
Diptera
Language English
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Snippet Drosophila is one of the most fully described eukaryotic organisms and, as a system, offers the most advanced genetic and molecular techniques.In particular,...
Drosophila is one of the most fully described eukaryotic organisms and, as a system, offers the most advanced genetic and molecular techniques. In particular,...
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SubjectTerms Animals
Biological and medical sciences
development
Drosophila
Drosophila - embryology
Drosophila - physiology
Electrophysiology
embryo
Fundamental and applied biological sciences. Psychology
Genetics
Insecta
Invertebrates
Life cycle. Embryology. Development
neuromuscular junction
Physiology. Development
Synapses - physiology
synaptogenesis
Title Synaptogenesis in Drosophila: Coupling genetics and electrophysiology
URI https://dx.doi.org/10.1016/0928-4257(94)90023-X
https://www.ncbi.nlm.nih.gov/pubmed/7833856
https://search.proquest.com/docview/16708454
https://search.proquest.com/docview/77687717
Volume 88
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