Cell growth inhibition and apoptotic effect of the rexinoid 6-OH-11-O-hydroxyphenantrene on human osteosarcoma and mesenchymal stem cells

• Published in: Toxicology in vitro Vol. 26; no. 1; pp. 142 - 149
• Main Authors: Dozza, Barbara, Papi, Alessio, Lucarelli, Enrico, Scotlandi, Katia, Pierini, Michela, Tresca, Giuseppina, Donati, Davide, Orlandi, Marina
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2012
• Subjects: aggression; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; caspases; Cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; Cells, Cultured; cytotoxicity; dose response; Humans; in vivo studies; Mesenchymal stem cells; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - pathology; methylene blue; neoplasm cells; Osteosarcoma; Osteosarcoma cells; Retinoids; stem cells; Tretinoin - analogs & derivatives; Tretinoin - pharmacology; vitamin A; Western blotting; Cell growth; OS; IIF; Retinoids; Osteosarcoma cells; ATRA; MSC; Mesenchymal stem cells; Apoptosis

► The rexinoid IIF is a synthetic derivative of ATRA with clinical potential. ► IIF is able to induce growth inhibition and apoptosis in different human OS cells and MSC. ► IIF may be an effective compound for anticancer treatment, including that of OS. Natural derivatives of vitamin A, including al...