Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus

• Published in: Hearing research Vol. 345; pp. 57 - 68
• Main Authors: Cao, Xiao-Jie, Oertel, Donata
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017
• Subjects: Animals; Auditory Pathways - cytology; Auditory Pathways - drug effects; Auditory Pathways - metabolism; Cochlear Nucleus - cytology; Cochlear Nucleus - drug effects; Cochlear Nucleus - metabolism; Gene Expression Regulation; Genetic compensation; Genotype; HCN; Homeostasis; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - antagonists & inhibitors; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - deficiency; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics; KCNA; Kv1.1 Potassium Channel - antagonists & inhibitors; Kv1.1 Potassium Channel - deficiency; Kv1.1 Potassium Channel - genetics; Membrane Potentials - drug effects; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Neuronal Plasticity; Patch-Clamp Techniques; Phenotype; Potassium Channel Blockers - pharmacology; Potassium Channels - deficiency; Potassium Channels - genetics; Time Factors; Ventral cochlear nucleus; Voltage-gated ion channels; Homeostasis; KCNA; HCN; Voltage-gated ion channels; Genetic compensation; Ventral cochlear nucleus

Low-voltage-activated K+ (gKL) and hyperpolarization-activated mixed cation conductances (gh) mediate currents, IKL and Ih, through channels of the Kv1 (KCNA) and HCN families respectively and give auditory neurons the temporal precision required for signaling information about the onset, fine struc...