Monofunctional alkylating agent-induced S-phase-dependent DNA damage

• Published in: Mutation Research/Environmental Mutagenesis and Related Subjects Vol. 216; no. 2; pp. 111 - 118
• Main Author: Schwartz, Jeffrey L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.1989
• Subjects: Alkylating Agents - toxicity; Animals; Bromodeoxyuridine - metabolism; Cell Line; Cricetinae; Cricetulus; DNA - drug effects; DNA - metabolism; DNA Damage; DNA elution; DNA replication; DNA Replication - drug effects; Female; Interphase - drug effects; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Monofunctional alkylating agents; Mutagens; Ovary; DNA elution; DNA replication; Monofunctional alkylating agents

Alkylating agents are S-phase-dependent clastogenic agents: Chromosome aberrations are not observed unless the treated cells have first undergone a replicative DNA synthesis. While DNA gaps resulting from misreplication off the alkylated template are believed to underlie aberration formation, the sp...