e-Antigen in patients with transient and chronic carriership of hepatitis B antigen

Serum samples from 39 patients with hepatitis B antigen (HBSAg) were studied for presence of e-antigen. 21 patients had HBSAg transiently and 18 were carriers of HBSAg for 14 months or more. All serum samples from the 18 carriers reacted in the e-antigen system; 16 individuals had e-antigen and 2 ha...

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Bibliographic Details
Published inScandinavian journal of infectious diseases Vol. 8; no. 4; p. 225
Main Authors Löfgren, B, Myhre, E, Nordenfelt, E
Format Journal Article
LanguageEnglish
Published England 01.01.1976
Subjects
Acute Disease
Antigens - analysis
Carrier State
Chronic Disease
Hepatitis B - enzymology
Hepatitis B - immunology
Hepatitis B Antigens - analysis
Liver Cirrhosis - immunology
Time Factors
Transaminases - blood
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Summary:Serum samples from 39 patients with hepatitis B antigen (HBSAg) were studied for presence of e-antigen. 21 patients had HBSAg transiently and 18 were carriers of HBSAg for 14 months or more. All serum samples from the 18 carriers reacted in the e-antigen system; 16 individuals had e-antigen and 2 had anti-e. In contrast, only 3 of the 21 patients with transient HBS-antigenemia were found to have e-antigen. The clinical course of 31 of the 39 patients was followed from the acute stage. All of the 18 patients who did not develop e-antigen became free from symptoms within 13 weeks. In the remaining 13 patients e-antigen was found and 10 became chronic HBSAg-carriers; 4 with biopsy-verified chronic hepatitis and 6 with biochemical findings consistent with this diagnosis.
ISSN:0036-5548
DOI:10.3109/inf.1976.8.issue-4.01