New tester strains with improved bioactivation capacity for the Drosophila wing-spot test

• Published in: Mutation Research/Environmental Mutagenesis and Related Subjects Vol. 216; no. 3; pp. 179 - 187
• Main Authors: Frölich, A., Würgler, F.E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.1989
• Subjects: Animals; Biotransformation; Cytochrome P-450; Diethylnitrosamine; Diethylnitrosamine - toxicity; Dose-Response Relationship, Drug; Drosophila; Drosophila melanogaster - drug effects; Drosophila melanogaster - genetics; Genetic control; Metabolic activation; Mutagenicity Tests - methods; Wings, Animal; Metabolic activation; Genetic control; Drosophila; Diethylnitrosamine; Cytochrome P-450

In Drosophila melanogaster new tester strains for the somatic mutation and recombination test (SMART) in the wing were constructed with the aim of increasing the metabolic capacity to activate promutagens. Some aspects of the genetic control of the xenobiotics metabolism in Drosophila are already kn...