New tester strains with improved bioactivation capacity for the Drosophila wing-spot test
In Drosophila melanogaster new tester strains for the somatic mutation and recombination test (SMART) in the wing were constructed with the aim of increasing the metabolic capacity to activate promutagens. Some aspects of the genetic control of the xenobiotics metabolism in Drosophila are already kn...
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| Published in | Mutation Research/Environmental Mutagenesis and Related Subjects Vol. 216; no. 3; pp. 179 - 187 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.06.1989
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| Subjects | |
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| Abstract | In
Drosophila melanogaster new tester strains for the somatic mutation and recombination test (SMART) in the wing were constructed with the aim of increasing the metabolic capacity to activate promutagens. Some aspects of the genetic control of the xenobiotics metabolism in Drosophila are already known. In the DDT-resistant strain Oregon R(R) the RI gene at position 65.0 on chromosome 2 is responsible for the high constitutive expression of cytochrome P-450-dependent activities typical for this strain. Therefore, chromosomes 1 and 2 in the original
mwh (multiple wing hairs) and
flr
3 (flare
3) tester strains were substituted for chromosomes 1 and 2 from the Oregon R(R) strain. In assays with the model promutagen diethylnitrosamine an increased sensitivity of about 2.5-fold was found for this new set of ‘HB’ strains (‘High Bioactivation (HB) cross’). |
|---|---|
| AbstractList | In
Drosophila melanogaster new tester strains for the somatic mutation and recombination test (SMART) in the wing were constructed with the aim of increasing the metabolic capacity to activate promutagens. Some aspects of the genetic control of the xenobiotics metabolism in Drosophila are already known. In the DDT-resistant strain Oregon R(R) the RI gene at position 65.0 on chromosome 2 is responsible for the high constitutive expression of cytochrome P-450-dependent activities typical for this strain. Therefore, chromosomes 1 and 2 in the original
mwh (multiple wing hairs) and
flr
3 (flare
3) tester strains were substituted for chromosomes 1 and 2 from the Oregon R(R) strain. In assays with the model promutagen diethylnitrosamine an increased sensitivity of about 2.5-fold was found for this new set of ‘HB’ strains (‘High Bioactivation (HB) cross’). In Drosophila melanogaster new tester strains for the somatic mutation and recombination test (SMART) in the wing were constructed with the aim of increasing the metabolic capacity to activate promutagens. Some aspects of the genetic control of the xenobiotics metabolism in Drosophila are already known. In the DDT-resistant strain Oregon R(R) the RI gene at position 65.0 on chromosome 2 is responsible for the high constitutive expression of cytochrome P-450-dependent activities typical for this strain. Therefore, chromosomes 1 and 2 in the original mwh (multiple wing hairs) and flr3 (flare3) tester strains were substituted for chromosomes 1 and 2 from the Oregon R(R) strain. In assays with the model promutagen diethylnitrosamine an increased sensitivity of about 2.5-fold was found for this new set of 'HB' strains ('High Bioactivation (HB) cross'). |
| Author | Würgler, F.E. Frölich, A. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/2499781$$D View this record in MEDLINE/PubMed |
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| Keywords | Metabolic activation Genetic control Drosophila Diethylnitrosamine Cytochrome P-450 |
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| References | Hällström (BIB6) 1987; 36 Lindsley, Grell (BIB11) 1968 Würgler, Vogel (BIB17) 1986; Vol. 10 Hällström, Magnusson, Ramel (BIB8) 1982; 92 Zijlstra, Vogel, Breimer (BIB19) 1987; Vol. 8 Garcia-Bellido, Dapena (BIB3) 1974; 128 Kikkawa (BIB10) 1961; 9 Zijlstra, Vogel, Breimer (BIB18) 1984; 48 Hällström (BIB5) 1986 Vogel (BIB13) 1980; 43 Hällström, Blanck, Atuma (BIB9) 1984; 33 Dapkus, Merrell (BIB1) 1977; 87 Frei, Würgler (BIB2) 1988; 203 Graf, Würgler, Katz, Frei, Juon, Hall, Kale (BIB4) 1984; 6 Waters, Nix, Epler (BIB16) 1983; 46 Sankaranarayanan (BIB12) 1981 Vogel, Sobels (BIB15) 1976; Vol. 4 Vogel, Leigh (BIB14) 1975; 29 Hällström, Blanck (BIB7) 1985; 56 Hällström (10.1016/0165-1161(89)90003-4_BIB8) 1982; 92 Hällström (10.1016/0165-1161(89)90003-4_BIB5) 1986 Kikkawa (10.1016/0165-1161(89)90003-4_BIB10) 1961; 9 Vogel (10.1016/0165-1161(89)90003-4_BIB15) 1976; Vol. 4 Garcia-Bellido (10.1016/0165-1161(89)90003-4_BIB3) 1974; 128 Graf (10.1016/0165-1161(89)90003-4_BIB4) 1984; 6 Vogel (10.1016/0165-1161(89)90003-4_BIB14) 1975; 29 Zijlstra (10.1016/0165-1161(89)90003-4_BIB18) 1984; 48 Würgler (10.1016/0165-1161(89)90003-4_BIB17) 1986; Vol. 10 Hällström (10.1016/0165-1161(89)90003-4_BIB6) 1987; 36 Lindsley (10.1016/0165-1161(89)90003-4_BIB11) 1968 Sankaranarayanan (10.1016/0165-1161(89)90003-4_BIB12) 1981 Hällström (10.1016/0165-1161(89)90003-4_BIB9) 1984; 33 Waters (10.1016/0165-1161(89)90003-4_BIB16) 1983; 46 Zijlstra (10.1016/0165-1161(89)90003-4_BIB19) 1987; Vol. 8 Vogel (10.1016/0165-1161(89)90003-4_BIB13) 1980; 43 Frei (10.1016/0165-1161(89)90003-4_BIB2) 1988; 203 Hällström (10.1016/0165-1161(89)90003-4_BIB7) 1985; 56 Dapkus (10.1016/0165-1161(89)90003-4_BIB1) 1977; 87 |
| References_xml | – volume: Vol. 4 start-page: 93 year: 1976 end-page: 142 ident: BIB15 article-title: The function of Drosophila in genetic toxicology testing publication-title: Chemical Mutagens, Principles and Methods for their Detection – volume: Vol. 10 start-page: 1 year: 1986 end-page: 72 ident: BIB17 article-title: In vivo mutagenicity testing using somatic cells of publication-title: Chemical Mutagens, Principles and Methods for their Detection – volume: 29 start-page: 383 year: 1975 end-page: 396 ident: BIB14 article-title: Concentration-effect studies with MMS, TEB, 2,4,6-C13-PDMT, and DEN on the induction of dominant and recessive lethals, chromosome loss, and translocations in Drosophila sperm publication-title: Mutation Res. – volume: 6 start-page: 153 year: 1984 end-page: 188 ident: BIB4 article-title: Somatic mutation and recombination test in publication-title: Environ. Mutagen. – start-page: 419 year: 1986 end-page: 425 ident: BIB5 article-title: Genetic regulation of the cytochrome P-450 system in publication-title: Genetic Toxicology of Environmental Chemicals, Part B, Genetic Effects and Applied Mutagenesis – volume: 46 start-page: 55 year: 1983 end-page: 66 ident: BIB16 article-title: Studies on the relationship between dimethylnitrosamine-demethylase activity and dimethylnitrosamine-dependent mutagenesis in publication-title: Chem.-Biol. Interact. – volume: 92 start-page: 161 year: 1982 end-page: 168 ident: BIB8 article-title: Relation between the somatic toxicity of dimethylnitrosamine and a genetically determined variation in the level and induction of cytochrome P-450 in publication-title: Mutation Res. – volume: 33 start-page: 13 year: 1984 end-page: 20 ident: BIB9 article-title: Genetic variation in cytochrome P-450 and xenobiotic metabolism in publication-title: Biochem. Pharmacol. – volume: 87 start-page: 685 year: 1977 end-page: 697 ident: BIB1 article-title: Chromosomal analysis of DDT-resistance in a long-term selected population of publication-title: Genetics – volume: 128 start-page: 117 year: 1974 end-page: 130 ident: BIB3 article-title: Induction, detection and characterization of cell differentiation mutants in Drosophila publication-title: Mol. Gen. Genet. – volume: 203 start-page: 297 year: 1988 end-page: 308 ident: BIB2 article-title: Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result publication-title: Mutation Res. – volume: Vol. 8 start-page: 121 year: 1987 end-page: 154 ident: BIB19 article-title: Pharmacological and toxicological aspects of mutagenicity research in publication-title: Reviews in Biochemical Toxicology – volume: 9 start-page: 1 year: 1961 end-page: 20 ident: BIB10 article-title: Genetical studies on the resistance of parathion in publication-title: Annu. Rep. Sci. Works Fac. Sci. – volume: 56 start-page: 157 year: 1985 end-page: 171 ident: BIB7 article-title: Genetic regulation of the cytochrome P-450 system in publication-title: Chem.-Biol. Interact. – volume: 48 start-page: 317 year: 1984 end-page: 338 ident: BIB18 article-title: Strain-differences and inducibility of microsomal oxidative enzymes in publication-title: Chem.-Biol. Interact. – volume: 36 start-page: 2279 year: 1987 end-page: 2282 ident: BIB6 article-title: Genetic variation in cytochrome P-450-dependent demethylation in publication-title: Biochem. Pharmacol. – volume: 43 start-page: 201 year: 1980 end-page: 211 ident: BIB13 article-title: Genetical relationship between resistance to insecticides and promutagents in two Drosophila populations publication-title: Arch. Toxicol. – year: 1968 ident: BIB11 article-title: Genetic Variations of – start-page: 787 year: 1981 end-page: 855 ident: BIB12 article-title: Comparative mutagenicity of dimethylnitrosamine and diethylnitrosamine publication-title: Comparative Chemical Mutagenesis – volume: 43 start-page: 201 year: 1980 ident: 10.1016/0165-1161(89)90003-4_BIB13 article-title: Genetical relationship between resistance to insecticides and promutagents in two Drosophila populations publication-title: Arch. Toxicol. doi: 10.1007/BF00297585 – volume: 48 start-page: 317 year: 1984 ident: 10.1016/0165-1161(89)90003-4_BIB18 article-title: Strain-differences and inducibility of microsomal oxidative enzymes in Drosophila melanogaster flies publication-title: Chem.-Biol. Interact. doi: 10.1016/0009-2797(84)90143-1 – volume: 46 start-page: 55 year: 1983 ident: 10.1016/0165-1161(89)90003-4_BIB16 article-title: Studies on the relationship between dimethylnitrosamine-demethylase activity and dimethylnitrosamine-dependent mutagenesis in Drosophila melanogaster publication-title: Chem.-Biol. Interact. doi: 10.1016/0009-2797(83)90006-6 – volume: 203 start-page: 297 year: 1988 ident: 10.1016/0165-1161(89)90003-4_BIB2 article-title: Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result publication-title: Mutation Res. doi: 10.1016/0165-1161(88)90019-2 – volume: 56 start-page: 157 year: 1985 ident: 10.1016/0165-1161(89)90003-4_BIB7 article-title: Genetic regulation of the cytochrome P-450 system in Drosophila melanogaster publication-title: Chem.-Biol. Interact. doi: 10.1016/0009-2797(85)90003-1 – volume: 128 start-page: 117 year: 1974 ident: 10.1016/0165-1161(89)90003-4_BIB3 article-title: Induction, detection and characterization of cell differentiation mutants in Drosophila publication-title: Mol. Gen. Genet. doi: 10.1007/BF02654485 – volume: 33 start-page: 13 year: 1984 ident: 10.1016/0165-1161(89)90003-4_BIB9 article-title: Genetic variation in cytochrome P-450 and xenobiotic metabolism in Drosophila melanogaster publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(84)90364-2 – volume: Vol. 8 start-page: 121 year: 1987 ident: 10.1016/0165-1161(89)90003-4_BIB19 article-title: Pharmacological and toxicological aspects of mutagenicity research in Drosophila melanogaster – volume: 9 start-page: 1 year: 1961 ident: 10.1016/0165-1161(89)90003-4_BIB10 article-title: Genetical studies on the resistance of parathion in Drosophila melanogaster. I. Gene analyses – year: 1968 ident: 10.1016/0165-1161(89)90003-4_BIB11 – volume: 29 start-page: 383 year: 1975 ident: 10.1016/0165-1161(89)90003-4_BIB14 article-title: Concentration-effect studies with MMS, TEB, 2,4,6-C13-PDMT, and DEN on the induction of dominant and recessive lethals, chromosome loss, and translocations in Drosophila sperm publication-title: Mutation Res. doi: 10.1016/0027-5107(75)90059-7 – volume: 36 start-page: 2279 year: 1987 ident: 10.1016/0165-1161(89)90003-4_BIB6 article-title: Genetic variation in cytochrome P-450-dependent demethylation in Drosophila melanogaster publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(87)90591-0 – start-page: 419 year: 1986 ident: 10.1016/0165-1161(89)90003-4_BIB5 article-title: Genetic regulation of the cytochrome P-450 system in Drosophila melanogaster – volume: Vol. 10 start-page: 1 year: 1986 ident: 10.1016/0165-1161(89)90003-4_BIB17 article-title: In vivo mutagenicity testing using somatic cells of Drosophila melanogaster – volume: Vol. 4 start-page: 93 year: 1976 ident: 10.1016/0165-1161(89)90003-4_BIB15 article-title: The function of Drosophila in genetic toxicology testing – volume: 87 start-page: 685 year: 1977 ident: 10.1016/0165-1161(89)90003-4_BIB1 article-title: Chromosomal analysis of DDT-resistance in a long-term selected population of Drosophila melanogaster publication-title: Genetics doi: 10.1093/genetics/87.4.685 – volume: 6 start-page: 153 year: 1984 ident: 10.1016/0165-1161(89)90003-4_BIB4 article-title: Somatic mutation and recombination test in Drosophila melanogaster publication-title: Environ. Mutagen. doi: 10.1002/em.2860060206 – start-page: 787 year: 1981 ident: 10.1016/0165-1161(89)90003-4_BIB12 article-title: Comparative mutagenicity of dimethylnitrosamine and diethylnitrosamine – volume: 92 start-page: 161 year: 1982 ident: 10.1016/0165-1161(89)90003-4_BIB8 article-title: Relation between the somatic toxicity of dimethylnitrosamine and a genetically determined variation in the level and induction of cytochrome P-450 in Drosophila melanogaster publication-title: Mutation Res. doi: 10.1016/0027-5107(82)90220-2 |
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Drosophila melanogaster new tester strains for the somatic mutation and recombination test (SMART) in the wing were constructed with the aim of increasing... In Drosophila melanogaster new tester strains for the somatic mutation and recombination test (SMART) in the wing were constructed with the aim of increasing... |
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| SubjectTerms | Animals Biotransformation Cytochrome P-450 Diethylnitrosamine Diethylnitrosamine - toxicity Dose-Response Relationship, Drug Drosophila Drosophila melanogaster - drug effects Drosophila melanogaster - genetics Genetic control Metabolic activation Mutagenicity Tests - methods Wings, Animal |
| Title | New tester strains with improved bioactivation capacity for the Drosophila wing-spot test |
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