Subchronic stress-induced depressive behavior in ovariectomized mice
Mood disorders including depression are more common in women than men, particularly in times of lower estradiol levels. In this study, we investigated the effect of estrogen on emotional behavior in mice in a stress environment. Female mice were divided into four groups: two groups were ovariectomiz...
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Published in | Life sciences (1973) Vol. 84; no. 15; pp. 512 - 516 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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10.04.2009
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Abstract | Mood disorders including depression are more common in women than men, particularly in times of lower estradiol levels. In this study, we investigated the effect of estrogen on emotional behavior in mice in a stress environment.
Female mice were divided into four groups: two groups were ovariectomized (OVX) and two were sham-operated. One group each of OVX and sham mice was kept in a normal environment and the other groups were assigned to a daily stress (1 h/day) for 7 days from 5 days after operation. On the 14th day after operation, subjects were measured to assess behavioral specificity, locomotor activity, elevated plus-maze (EPM) behavior, passive avoidance (PA) behavior and forced swimming behavior.
The OVX plus stress (OVX
+
S) group showed a significant prolongation of immobility compared with the other groups. In all the groups there were no changes in locomotor activity, EPM behavior or PA behavior. We further examined the effect of estrogen against depressive behavior in the OVX
+
S group. The vehicle or 17β-estradiol (E2) was administered s.c. to OVX
+
S mice for 4 days beginning on post-operative day 11. Subchronic E2 treatment decreased the stress response and improved depressive behavior relative to the vehicle group.
These data have important implications regarding the prevention of depression in postmenopausal women undergoing estrogen therapy. |
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AbstractList | Mood disorders including depression are more common in women than men, particularly in times of lower estradiol levels. In this study, we investigated the effect of estrogen on emotional behavior in mice in a stress environment.
Female mice were divided into four groups: two groups were ovariectomized (OVX) and two were sham-operated. One group each of OVX and sham mice was kept in a normal environment and the other groups were assigned to a daily stress (1 h/day) for 7 days from 5 days after operation. On the 14th day after operation, subjects were measured to assess behavioral specificity, locomotor activity, elevated plus-maze (EPM) behavior, passive avoidance (PA) behavior and forced swimming behavior.
The OVX plus stress (OVX+S) group showed a significant prolongation of immobility compared with the other groups. In all the groups there were no changes in locomotor activity, EPM behavior or PA behavior. We further examined the effect of estrogen against depressive behavior in the OVX+S group. The vehicle or 17beta-estradiol (E2) was administered s.c. to OVX+S mice for 4 days beginning on post-operative day 11. Subchronic E2 treatment decreased the stress response and improved depressive behavior relative to the vehicle group.
These data have important implications regarding the prevention of depression in postmenopausal women undergoing estrogen therapy. Mood disorders including depression are more common in women than men, particularly in times of lower estradiol levels. In this study, we investigated the effect of estrogen on emotional behavior in mice in a stress environment. Female mice were divided into four groups: two groups were ovariectomized (OVX) and two were sham-operated. One group each of OVX and sham mice was kept in a normal environment and the other groups were assigned to a daily stress (1 h/day) for 7 days from 5 days after operation. On the 14th day after operation, subjects were measured to assess behavioral specificity, locomotor activity, elevated plus-maze (EPM) behavior, passive avoidance (PA) behavior and forced swimming behavior. The OVX plus stress (OVX + S) group showed a significant prolongation of immobility compared with the other groups. In all the groups there were no changes in locomotor activity, EPM behavior or PA behavior. We further examined the effect of estrogen against depressive behavior in the OVX + S group. The vehicle or 17β-estradiol (E2) was administered s.c. to OVX + S mice for 4 days beginning on post-operative day 11. Subchronic E2 treatment decreased the stress response and improved depressive behavior relative to the vehicle group. These data have important implications regarding the prevention of depression in postmenopausal women undergoing estrogen therapy. AIMSMood disorders including depression are more common in women than men, particularly in times of lower estradiol levels. In this study, we investigated the effect of estrogen on emotional behavior in mice in a stress environment.MAIN METHODSFemale mice were divided into four groups: two groups were ovariectomized (OVX) and two were sham-operated. One group each of OVX and sham mice was kept in a normal environment and the other groups were assigned to a daily stress (1 h/day) for 7 days from 5 days after operation. On the 14th day after operation, subjects were measured to assess behavioral specificity, locomotor activity, elevated plus-maze (EPM) behavior, passive avoidance (PA) behavior and forced swimming behavior.KEY FINDINGSThe OVX plus stress (OVX+S) group showed a significant prolongation of immobility compared with the other groups. In all the groups there were no changes in locomotor activity, EPM behavior or PA behavior. We further examined the effect of estrogen against depressive behavior in the OVX+S group. The vehicle or 17beta-estradiol (E2) was administered s.c. to OVX+S mice for 4 days beginning on post-operative day 11. Subchronic E2 treatment decreased the stress response and improved depressive behavior relative to the vehicle group.SIGNIFICANCEThese data have important implications regarding the prevention of depression in postmenopausal women undergoing estrogen therapy. |
Author | Niijima, Fukie Wakui, Kenji Arai, Yuichiro Tan-No, Koichi Nakagawasai, Osamu Onogi, Hiroshi Mitazaki, Satoru Oba, Akira Sato, Atsushi Tadano, Takeshi |
Author_xml | – sequence: 1 givenname: Osamu surname: Nakagawasai fullname: Nakagawasai, Osamu email: osamun@tohoku-pharm.ac.jp organization: Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan – sequence: 2 givenname: Akira surname: Oba fullname: Oba, Akira organization: Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan – sequence: 3 givenname: Atsushi surname: Sato fullname: Sato, Atsushi organization: Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan – sequence: 4 givenname: Yuichiro surname: Arai fullname: Arai, Yuichiro organization: Division of Pharmacology, School of Pharmaceutical Sciences, Ohu University, Koriyama 963-8611, Japan – sequence: 5 givenname: Satoru surname: Mitazaki fullname: Mitazaki, Satoru organization: Laboratoy of Forensic Toxicology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Japan – sequence: 6 givenname: Hiroshi surname: Onogi fullname: Onogi, Hiroshi organization: Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan – sequence: 7 givenname: Kenji surname: Wakui fullname: Wakui, Kenji organization: Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan – sequence: 8 givenname: Fukie surname: Niijima fullname: Niijima, Fukie organization: Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan – sequence: 9 givenname: Koichi surname: Tan-No fullname: Tan-No, Koichi organization: Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan – sequence: 10 givenname: Takeshi surname: Tadano fullname: Tadano, Takeshi organization: Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan |
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Keywords | Forced swimming test Depression Ovariectomy Estradiol Stress |
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SubjectTerms | Animals Avoidance Learning - physiology Behavior, Animal - physiology Chronic Disease Depression Depression - etiology Depression - metabolism Depression - physiopathology Depression - prevention & control Disease Models, Animal Estradiol Estradiol - metabolism Estradiol - therapeutic use Female Forced swimming test Maze Learning - physiology Mice Mice, Inbred Strains Motor Activity - physiology Ovariectomy Stress Stress, Psychological - complications Stress, Psychological - metabolism Stress, Psychological - physiopathology Swimming - physiology |
Title | Subchronic stress-induced depressive behavior in ovariectomized mice |
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