Entry mechanisms of herpes simplex virus 1 into murine epidermis: involvement of nectin-1 and herpesvirus entry mediator as cellular receptors

• Published in: Journal of virology Vol. 89; no. 1; pp. 262 - 274
• Main Authors: Petermann, Philipp, Thier, Katharina, Rahn, Elena, Rixon, Frazer J, Bloch, Wilhelm, Özcelik, Semra, Krummenacher, Claude, Barron, Martin J, Dixon, Michael J, Scheu, Stefanie, Pfeffer, Klaus, Knebel-Mörsdorf, Dagmar
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.01.2015
• Subjects: Animals; Cell Adhesion Molecules - metabolism; Herpes simplex virus 1; Herpes simplex virus 2; Herpesvirus; Herpesvirus 1, Human - physiology; Host-Pathogen Interactions; Keratinocytes - virology; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Nectins; Receptors, Tumor Necrosis Factor, Member 14 - metabolism; Receptors, Virus - metabolism; Skin - virology; Virus Internalization; Virus-Cell Interactions

Skin keratinocytes represent a primary entry site for herpes simplex virus 1 (HSV-1) in vivo. The cellular proteins nectin-1 and herpesvirus entry mediator (HVEM) act as efficient receptors for both serotypes of HSV and are sufficient for disease development mediated by HSV-2 in mice. How HSV-1 ente...