Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension
Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and breakdown of kinins, leading to increased blood pressure (BP). Furthermore, ACE inhibitors are effective anti-hypertensive agents. A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was...
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| Published in | Biochemical and biophysical research communications Vol. 184; no. 1; pp. 9 - 15 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
San Diego, CA
Elsevier Inc
15.04.1992
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0006-291X 1090-2104 |
| DOI | 10.1016/0006-291X(92)91150-O |
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| Abstract | Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and breakdown of kinins, leading to increased blood pressure (BP). Furthermore, ACE inhibitors are effective anti-hypertensive agents. A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was examined by PCR in a cross-sectional study of 80 hypertensive (HT) and 93 normotensive (NT) subjects whose parents had a similar BP status at age ≥50. The frequency of the insertion allele was 0.56 in HTs and 0.41 in NTs, and the difference between observed alleles in all subjects in each group was significant (χ2 = 7.6, P<0.01). The data thus provide evidence in favour of an association of HT with a polymorphism at the ACE locus (17q23), so implicating this locus, and possibly a genetic variant of ACE itself, in human essential hypertension. |
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| AbstractList | A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was examined by PCR in a cross-sectional study of 80 hypertensive (HT) and 93 normotensive (NT) subjects whose parents had a similar BP status at age greater than or equal to 50. The frequency of the insertion allele was 0.56 in HTs and 0.41 in NTs, and the difference between observed alleles in all subjects in each group was significant ( chi super(2) = 7.6, P < 0.01). The data thus provide evidence in favour of an association of HT with a polymorphism at the ACE locus (17q23), so implicating this locus, and possibly a genetic variant of ACE itself, in human essential hypertension. Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and breakdown of kinins, leading to increased blood pressure (BP). Furthermore, ACE inhibitors are effective antihypertensive agents. A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was examined by PCR in a cross-sectional study of 80 hypertensive (HT) and 93 normotensive (NT) subjects whose parents had a similar BP status at age greater than or equal to 50. The frequency of the insertion allele was 0.56 in HTs and 0.41 in NTs, and the difference between observed alleles in all subjects in each group was significant (chi 2 = 7.6, P less than 0.01). The data thus provide evidence in favour of an association of HT with a polymorphism at the ACE locus (17q23), so implicating this locus, and possibly a genetic variant of ACE itself, in human essential hypertension.Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and breakdown of kinins, leading to increased blood pressure (BP). Furthermore, ACE inhibitors are effective antihypertensive agents. A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was examined by PCR in a cross-sectional study of 80 hypertensive (HT) and 93 normotensive (NT) subjects whose parents had a similar BP status at age greater than or equal to 50. The frequency of the insertion allele was 0.56 in HTs and 0.41 in NTs, and the difference between observed alleles in all subjects in each group was significant (chi 2 = 7.6, P less than 0.01). The data thus provide evidence in favour of an association of HT with a polymorphism at the ACE locus (17q23), so implicating this locus, and possibly a genetic variant of ACE itself, in human essential hypertension. Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and breakdown of kinins, leading to increased blood pressure (BP). Furthermore, ACE inhibitors are effective antihypertensive agents. A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was examined by PCR in a cross-sectional study of 80 hypertensive (HT) and 93 normotensive (NT) subjects whose parents had a similar BP status at age greater than or equal to 50. The frequency of the insertion allele was 0.56 in HTs and 0.41 in NTs, and the difference between observed alleles in all subjects in each group was significant (chi 2 = 7.6, P less than 0.01). The data thus provide evidence in favour of an association of HT with a polymorphism at the ACE locus (17q23), so implicating this locus, and possibly a genetic variant of ACE itself, in human essential hypertension. Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and breakdown of kinins, leading to increased blood pressure (BP). Furthermore, ACE inhibitors are effective anti-hypertensive agents. A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was examined by PCR in a cross-sectional study of 80 hypertensive (HT) and 93 normotensive (NT) subjects whose parents had a similar BP status at age ≥50. The frequency of the insertion allele was 0.56 in HTs and 0.41 in NTs, and the difference between observed alleles in all subjects in each group was significant (χ2 = 7.6, P<0.01). The data thus provide evidence in favour of an association of HT with a polymorphism at the ACE locus (17q23), so implicating this locus, and possibly a genetic variant of ACE itself, in human essential hypertension. |
| Author | Griffiths, Lyn R. Zee, Robert Y.L. Lou, Yi-kun Morris, Brian J. |
| Author_xml | – sequence: 1 givenname: Robert Y.L. surname: Zee fullname: Zee, Robert Y.L. – sequence: 2 givenname: Yi-kun surname: Lou fullname: Lou, Yi-kun – sequence: 3 givenname: Lyn R. surname: Griffiths fullname: Griffiths, Lyn R. – sequence: 4 givenname: Brian J. surname: Morris fullname: Morris, Brian J. |
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| Cites_doi | 10.1021/bi00439a001 10.1016/1050-1738(91)90035-D 10.1016/S0021-9258(18)98626-6 10.1097/00004872-199109000-00009 10.1016/0006-291X(88)90508-6 10.1111/j.1440-1681.1991.tb01639.x 10.1093/nar/20.6.1433-a 10.1016/0092-8674(91)90584-L 10.1089/dna.1.1984.3.457 10.1038/353521a0 10.1016/S0006-291X(05)81445-7 10.1161/01.HYP.18.3_Suppl.I29 10.1161/01.HYP.16.6.712 10.1097/00004872-199111000-00003 10.1161/01.HYP.14.6.614 10.1172/JCI114844 10.1038/339237a0 10.1042/cs0710345 |
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| Copyright | 1992 Academic Press, Inc. 1992 INIST-CNRS |
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| Keywords | Vascular disease Human Hypertension Enzyme Angiotensin converting enzyme Polymorphism |
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| References | Hardman, Hort, Catanzaro, Tellam, Baxter, Morris, Shine (bib3) 1984; 3 Morris, Griffiths (bib6) 1988; 150 Mattei, Hubert, Alhenc-Gelas, Roeckel, Corvol, Soubrier (bib14) 1989; 51 Erdös, Skidgel (bib2) 1987; 56 Soubrier, Jeunemaitre, Rigat, Houot, Cambien, Corvol (bib8) 1990; 16 Hubert, Houot, Corvol, Soubrier (bib17) 1991; 266 Hilbert, Lindpainter, Beckmann, Serikawa, Soubrier, Dubay, Cartwright, De Gouyen, Julier, Takahashi, Vincent, Ganten, Georges, Lathrop (bib12) 1991; 353 Naftilan, Williams, Burt, Paul, Pratt, Hobart, Chirgwin, Dzau (bib7) 1989; 14 Barley, Carter, Cruikshank, Jeffery, Smith, Charlett, Webb (bib10) 1991; 9 Rigat, Hubert, Corvol, Soubrier (bib16) 1992 Morris (bib25) 1992 Kwok, Higuchi (bib19) 1989; 339 Zee, Ying, Morris, Griffiths (bib9) 1991; 9 Herrera, Ruiz-Opazo (bib5) 1991; 1 Williams, Hunt, Hasstedt, Hopkins, Wu, Berry, Stults, Barlow, Schumacher, Lifton, Lalouel (bib4) 1991; 18 (bib1) 1990; Vol. 1 Cavenee, Leader, Mohandas, Pearson, White (bib18) 1984; 36 Lee (bib23) 1985; 22 Harper, Barrera-Saldana, Saunders (bib21) 1982; 34 Ehlers, Riordan (bib26) 1989; 28 Gray (bib22) 1984; 6 Morris (bib24) 1986; 71 Okunushi, Kawamoto, Kurobe, Oka, Ishii, Tanaka, Miyazaki (bib11) 1991; 18 Ying, Zee, Griffiths, Morris (bib20) 1991; 181 Jacob, Lindpainter, Lincoln, Kusumi, Bunker, Mao, Ganten, Dzau, Lander (bib13) 1991; 67 Rigat, Hubert, Alhenc-Gelas, Cambien, Corvol, Soubrier (bib15) 1990; 86 Lee (10.1016/0006-291X(92)91150-O_bib23) 1985; 22 Zee (10.1016/0006-291X(92)91150-O_bib9) 1991; 9 Gray (10.1016/0006-291X(92)91150-O_bib22) 1984; 6 Morris (10.1016/0006-291X(92)91150-O_bib6) 1988; 150 Ying (10.1016/0006-291X(92)91150-O_bib20) 1991; 181 Rigat (10.1016/0006-291X(92)91150-O_bib15) 1990; 86 Hubert (10.1016/0006-291X(92)91150-O_bib17) 1991; 266 Cavenee (10.1016/0006-291X(92)91150-O_bib18) 1984; 36 Morris (10.1016/0006-291X(92)91150-O_bib24) 1986; 71 Hilbert (10.1016/0006-291X(92)91150-O_bib12) 1991; 353 Kwok (10.1016/0006-291X(92)91150-O_bib19) 1989; 339 Erdös (10.1016/0006-291X(92)91150-O_bib2) 1987; 56 Naftilan (10.1016/0006-291X(92)91150-O_bib7) 1989; 14 Okunushi (10.1016/0006-291X(92)91150-O_bib11) 1991; 18 Herrera (10.1016/0006-291X(92)91150-O_bib5) 1991; 1 Mattei (10.1016/0006-291X(92)91150-O_bib14) 1989; 51 (10.1016/0006-291X(92)91150-O_bib1) 1990; Vol. 1 Morris (10.1016/0006-291X(92)91150-O_bib25) 1992 Ehlers (10.1016/0006-291X(92)91150-O_bib26) 1989; 28 Barley (10.1016/0006-291X(92)91150-O_bib10) 1991; 9 Hardman (10.1016/0006-291X(92)91150-O_bib3) 1984; 3 Harper (10.1016/0006-291X(92)91150-O_bib21) 1982; 34 Jacob (10.1016/0006-291X(92)91150-O_bib13) 1991; 67 Rigat (10.1016/0006-291X(92)91150-O_bib16) 1992 Soubrier (10.1016/0006-291X(92)91150-O_bib8) 1990; 16 Williams (10.1016/0006-291X(92)91150-O_bib4) 1991; 18 |
| References_xml | – volume: 1 start-page: 185 year: 1991 end-page: 189 ident: bib5 publication-title: Trends Cardiovasc. Med. – volume: 9 start-page: 993 year: 1991 end-page: 996 ident: bib10 publication-title: J. Hypertens. – volume: 34 start-page: 227 year: 1982 end-page: 234 ident: bib21 publication-title: Am. J. Hum. Genet. – volume: 22 start-page: 105 year: 1985 end-page: 126 ident: bib23 publication-title: Blood Vessels – volume: 14 start-page: 614 year: 1989 end-page: 618 ident: bib7 publication-title: Hypertension – volume: 71 start-page: 345 year: 1986 end-page: 355 ident: bib24 publication-title: Clin. Sci. – volume: 18 start-page: 649 year: 1991 end-page: 659 ident: bib11 publication-title: Clin. Exp. Pharmacol. Physiol. – volume: 266 start-page: 15377 year: 1991 end-page: 15383 ident: bib17 publication-title: J. Biol. Chem. – volume: 18 start-page: I-29 year: 1991 end-page: I-37 ident: bib4 publication-title: Hypertension – volume: 56 start-page: 345 year: 1987 end-page: 348 ident: bib2 publication-title: Lab. Invest. – volume: 67 start-page: 213 year: 1991 end-page: 224 ident: bib13 publication-title: Cell – volume: 3 start-page: 457 year: 1984 end-page: 468 ident: bib3 publication-title: DNA – volume: 353 start-page: 521 year: 1991 end-page: 529 ident: bib12 publication-title: Nature – volume: 339 start-page: 237 year: 1989 end-page: 238 ident: bib19 publication-title: Nature – volume: 181 start-page: 486 year: 1991 end-page: 492 ident: bib20 publication-title: Biochem. Biophys. Res. Commun. – volume: 16 start-page: 712 year: 1990 end-page: 717 ident: bib8 publication-title: Hypertension – volume: 51 start-page: 1041 year: 1989 ident: bib14 publication-title: Cytogenet. Cell Genet. – volume: 36 start-page: 10 year: 1984 end-page: 24 ident: bib18 publication-title: Am. J. Hum. Genet. – volume: 150 start-page: 219 year: 1988 end-page: 224 ident: bib6 publication-title: Biochem. Biophys. Res. Commun. – volume: 6 start-page: 755 year: 1984 end-page: 781 ident: bib22 publication-title: Clin. Exp. Hypertens. – year: 1992 ident: bib25 publication-title: J. Hypertens – volume: Vol. 1 year: 1990 ident: bib1 publication-title: Hypertension, Pathophysiology, Diagnosis, and Management – volume: 86 start-page: 1343 year: 1990 end-page: 1346 ident: bib15 article-title: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half of the variance of serum enzyme levels publication-title: J Clin Invest – volume: 9 start-page: 825 year: 1991 end-page: 830 ident: bib9 publication-title: J. Hypertens. – volume: 28 start-page: 5311 year: 1989 end-page: 5318 ident: bib26 publication-title: Biochemistry – year: 1992 ident: bib16 article-title: PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene publication-title: Nucl Acids Res – volume: 28 start-page: 5311 year: 1989 ident: 10.1016/0006-291X(92)91150-O_bib26 publication-title: Biochemistry doi: 10.1021/bi00439a001 – volume: 1 start-page: 185 year: 1991 ident: 10.1016/0006-291X(92)91150-O_bib5 publication-title: Trends Cardiovasc. Med. doi: 10.1016/1050-1738(91)90035-D – volume: 266 start-page: 15377 year: 1991 ident: 10.1016/0006-291X(92)91150-O_bib17 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)98626-6 – volume: 9 start-page: 825 year: 1991 ident: 10.1016/0006-291X(92)91150-O_bib9 publication-title: J. Hypertens. doi: 10.1097/00004872-199109000-00009 – volume: 150 start-page: 219 year: 1988 ident: 10.1016/0006-291X(92)91150-O_bib6 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(88)90508-6 – volume: 18 start-page: 649 issue: 1991 year: 1991 ident: 10.1016/0006-291X(92)91150-O_bib11 publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/j.1440-1681.1991.tb01639.x – year: 1992 ident: 10.1016/0006-291X(92)91150-O_bib16 article-title: PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene publication-title: Nucl Acids Res doi: 10.1093/nar/20.6.1433-a – volume: 56 start-page: 345 year: 1987 ident: 10.1016/0006-291X(92)91150-O_bib2 publication-title: Lab. Invest. – volume: 67 start-page: 213 year: 1991 ident: 10.1016/0006-291X(92)91150-O_bib13 publication-title: Cell doi: 10.1016/0092-8674(91)90584-L – volume: 34 start-page: 227 year: 1982 ident: 10.1016/0006-291X(92)91150-O_bib21 publication-title: Am. J. Hum. Genet. – volume: 3 start-page: 457 year: 1984 ident: 10.1016/0006-291X(92)91150-O_bib3 publication-title: DNA doi: 10.1089/dna.1.1984.3.457 – volume: 353 start-page: 521 year: 1991 ident: 10.1016/0006-291X(92)91150-O_bib12 publication-title: Nature doi: 10.1038/353521a0 – volume: 181 start-page: 486 year: 1991 ident: 10.1016/0006-291X(92)91150-O_bib20 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(05)81445-7 – volume: 51 start-page: 1041 year: 1989 ident: 10.1016/0006-291X(92)91150-O_bib14 publication-title: Cytogenet. Cell Genet. – volume: 18 start-page: I-29 issue: suppl. I year: 1991 ident: 10.1016/0006-291X(92)91150-O_bib4 publication-title: Hypertension doi: 10.1161/01.HYP.18.3_Suppl.I29 – volume: 6 start-page: 755 year: 1984 ident: 10.1016/0006-291X(92)91150-O_bib22 publication-title: Clin. Exp. Hypertens. – volume: 16 start-page: 712 year: 1990 ident: 10.1016/0006-291X(92)91150-O_bib8 publication-title: Hypertension doi: 10.1161/01.HYP.16.6.712 – volume: 22 start-page: 105 year: 1985 ident: 10.1016/0006-291X(92)91150-O_bib23 publication-title: Blood Vessels – year: 1992 ident: 10.1016/0006-291X(92)91150-O_bib25 publication-title: J. Hypertens – volume: 9 start-page: 993 year: 1991 ident: 10.1016/0006-291X(92)91150-O_bib10 publication-title: J. Hypertens. doi: 10.1097/00004872-199111000-00003 – volume: 14 start-page: 614 year: 1989 ident: 10.1016/0006-291X(92)91150-O_bib7 publication-title: Hypertension doi: 10.1161/01.HYP.14.6.614 – volume: 86 start-page: 1343 year: 1990 ident: 10.1016/0006-291X(92)91150-O_bib15 article-title: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half of the variance of serum enzyme levels publication-title: J Clin Invest doi: 10.1172/JCI114844 – volume: Vol. 1 year: 1990 ident: 10.1016/0006-291X(92)91150-O_bib1 – volume: 36 start-page: 10 year: 1984 ident: 10.1016/0006-291X(92)91150-O_bib18 publication-title: Am. J. Hum. Genet. – volume: 339 start-page: 237 year: 1989 ident: 10.1016/0006-291X(92)91150-O_bib19 publication-title: Nature doi: 10.1038/339237a0 – volume: 71 start-page: 345 year: 1986 ident: 10.1016/0006-291X(92)91150-O_bib24 publication-title: Clin. Sci. doi: 10.1042/cs0710345 |
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| Snippet | Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and breakdown of kinins, leading to increased blood pressure (BP).... A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was examined by PCR in a cross-sectional study of 80 hypertensive (HT) and 93... |
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| SubjectTerms | Adult Aged Alleles Arterial hypertension. Arterial hypotension Base Sequence Biological and medical sciences Blood and lymphatic vessels Blood Pressure Cardiology. Vascular system Chromosome Deletion Clinical manifestations. Epidemiology. Investigative techniques. Etiology deletion dipeptidyl carboxypeptidase I DNA - blood DNA - genetics DNA - isolation & purification DNA Transposable Elements genes Genotype Humans hypertension Hypertension - enzymology Hypertension - genetics insertion Introns Leukocytes - enzymology man Medical sciences Molecular Sequence Data Oligodeoxyribonucleotides Oligonucleotides, Antisense Peptidyl-Dipeptidase A - genetics Polymerase Chain Reaction polymorphism Polymorphism, Genetic Promoter Regions, Genetic Reference Values |
| Title | Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension |
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