Differential regional and cellular distribution of β-amyloid precursor protein messenger RNAs containing and lacking the kunitz protease inhibitor domain in the brain of human, rat and mouse

• Published in: Neuroscience Vol. 53; no. 1; pp. 267 - 295
• Main Authors: Sola`, C., Mengod, G., Probst, A., Palacios, J.M.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.03.1993; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Amyloid beta-Protein Precursor - biosynthesis; Animals; Base Sequence; Biological and medical sciences; Blotting, Northern; Brain - anatomy & histology; Brain - metabolism; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Humans; In Situ Hybridization; Male; Medical sciences; Mice; Middle Aged; Molecular Sequence Data; Neurology; Oligonucleotides; Peptide Mapping; Rats; Rats, Wistar; RNA Probes; RNA, Messenger - metabolism; Rodentia; Serine Proteinase Inhibitors - metabolism; βAPP; PBS; SSC; SDS; KPI; Human; Nervous system diseases; Kunitz inhibitor; Rat; Enzyme; Alzheimer disease; Proteinase; Rodentia; Central nervous system; Amyloid precursor protein; Autoradiography; Vertebrata; Mammalia; Mouse; Animal; Distribution; Degenerative disease; Aminoacid sequence; Brain (vertebrata)

The β-amyloid precursor protein is the precursor of the main component of senile plaques (the β-amyloid peptide or β/A4) found in the brain of aged humans and, in higher amounts, in the brain of Alzheimer's disease and Down's syndrome subjects. Four different forms of β-amyloid precursor p...