Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors

• Published in: Molecular cancer therapeutics Vol. 5; no. 9; pp. 2317 - 2323
• Main Authors: Beliën, Ann, De Schepper, Stefanie, Floren, Wim, Janssens, Boud, Mariën, Ann, King, Peter, Van Dun, Jacky, Andries, Luc, Voeten, Jan, Bijnens, Luc, Janicot, Michel, Arts, Janine
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 01.09.2006
• Subjects: Animals; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Enzyme Inhibitors - pharmacology; Female; Gene Expression; Genes, Reporter; Green Fluorescent Proteins - genetics; HDAC; Histone Deacetylase Inhibitors; Histone Deacetylases - metabolism; Humans; Male; Mice; Mice, Nude; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - enzymology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; p21waf1,cip1; Promoter Regions, Genetic; real-time imaging; tumor xenografts; Xenograft Model Antitumor Assays - methods

Real-time analysis of gene expression in experimental tumor models represents a major tool to document disease biology and evaluate disease treatment. However, monitoring gene regulation in vivo still is an emerging field, and thus far it has not been linked to long-term tumor growth and disease out...