Unexpectedly high frequency of European parentage in Venezuelan patients with chronic lymphocytic leukemia

• Published in: Leukemia & lymphoma Vol. 53; no. 2; pp. 235 - 241
• Main Authors: Marquez, Maria-Elena, Deglesne, Pierre-Antoine, Lopez, Jose Luis, Costa, Osiris Da, Borrego, Mildred, Hernández, Marcos, Muller, Aixa, Ajchenbaum-Cymbalista, Florence, Romano, Egidio
• Format: Journal Article
• Language: English
• Published: United States Informa Healthcare 01.02.2012; Taylor & Francis
• Subjects: ADP-ribosyl Cyclase 1 - metabolism; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; CD38 antigen; Chronic lymphocytic leukemia; Complementarity Determining Regions - genetics; European Continental Ancestry Group - genetics; Female; Flow Cytometry; Humans; IGVH mutational status; Immunoglobulin Heavy Chains - genetics; Immunoglobulin Variable Region - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis; Leukemia, Lymphocytic, Chronic, B-Cell - ethnology; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Male; Membrane Glycoproteins - metabolism; Middle Aged; Mutation - genetics; Neoplasm Staging; Prognosis; Venezuela - ethnology; ZAP-70; ZAP-70 Protein-Tyrosine Kinase - metabolism

Abstract There is insufficient information on the characteristics of chronic lymphocytic leukemia (CLL) in Latin American patients. Immunoglobulin variable-region heavy-chain (IGVH) gene usage and mutation status and prognostic factors were investigated in patients resident in Venezuela. The most fr...